Preparation of Silver Nanowires via a Rapid,Scalable and Green Pathway

Rapid synthesis of silver nanowires(Ag NWs) with high quality and a broad processing window is challenging because of the low selectivity of the formation of multiply twinned particles at the nucleation stage for subsequent Ag NWs growth.Herein we report a systematic study of the water-involved heterogeneous nucleation of Ag NWs with high rate(less than 20 min) in a simple and scalable preparation method.Using glycerol as a reducing agent and a solvent with a high boiling point,the reaction is rapidly heated to 210 ℃ in air to synthesize Ag NWs with a very high yield in gram level.It is noted that the addition of a small dose of water plays a key role for obtaining highly pure Ag NWs in high yield,and the optimal water/glycerol ratio is0.25%.After investigating a series of forming factors including reaction temperature and dose of catalysts,the formation kinetics and mechanism of the Ag NWs are proposed.Compared to other preparation methods,our strategy is simple and reproducible.These Ag NWs show a strong Raman enhancement effect for organic molecules on their surface.     

Synthesis of Long-Chain β-Lactones and Their Antibacterial Activities against Pathogenic Mycobacteria

In the quest for new antibacterial agents, a series of novel long- and medium-chain mono- and disubstituted β-lactones was developed. Their activity against three pathogenic mycobacteria—M. abscessus, M. marinum, and M. tuberculosis—was assessed by the resazurin microtiter assay (REMA). Among the 16 β-lactones synthesized, only 3-hexadecyloxetan-2-one (VM005) exhibited promising activity against M. abscessus, whereas most of the β-lactones showed interesting activities against M. marinum, similar to that of the classical antibiotic, isoniazid. Regarding M. tuberculosis, six compounds were found to be active against this mycobacterium, with β-lactone VM008 [trans-(Z)-3-(hexadec-7-en-1-yl)-4-propyloxetan-2-one] being the best growth inhibitor. The promising antibacterial activities of the best compounds in this series suggest that these molecules may serve as leads for the development of much more efficient antimycobacterial agents.     

Nonhydrolyzable Heptose Bis- and Monophosphate Analogues Modulate Pro-inflammatory TIFA-NF-κB Signaling

d -Glycero-d -manno-heptose-1β,7-bisphosphate (HBP) and d -glycero-d -manno-heptose-1β-phosphate (H1P) are bacterial metabolites that were recently shown to stimulate inflammatory responses in host cells through the activation of the TIFA-dependent NF-κB pathway. To better understand structure-based activity in relation to this process, a family of nonhydrolyzable phosphonate analogues of HBP and H1P was synthesized. The inflammation modulation by which these molecules induce the TIFA-NF-κB signal axis was evaluated in vivo at a low-nanomolar concentration (6 nM) and compared to that of the natural metabolites. Our data showed that three phosphonate analogues had similar stimulatory activity to HBP, whereas two phosphonates antagonized HBP-induced TIFA-NF-κB signaling. These results open new horizons for the design of pro-inflammatory and innate immune modulators that could be used as vaccine adjuvant.     

简化形式的系统EMC预测分析技术概述

本文探讨了系统级简化形式的电磁兼容性预测分析方法，该方法对于只有几对发-收干扰对的系统EMI的预测分析简洁有效，它避免了大系统间繁复的建模与大量的数据采集及其计算工作，从而对于只考虑其结果的系统间的EMC预测分析提高了效率。     

渤海湾盆地石油地质储量和产量增长趋势的预测

渤海湾盆地的石油地质储量发现过程具有明显的渐进性、阶段性和长期性，石油产量的增长也具有一定的起伏性，用一个周期的单旋回哈伯特模型难以预测其发展趋势。通过分析渤海湾盆地的勘探开发历程，结合新一轮常规油气资源评价的结果，分别采用4个和3个哈伯特旋回拟合石油地质储量发现和产量增长曲线。预测结果显示，2005-2015年渤海湾盆地处于石油地质储量发现高峰期，2015年左右其石油产量达到高峰，之后处于下降趋势。实践证明，利用多旋回哈伯特模型对具有“多峰”特征的石油地质储量和产量的未来趋势进行预测是一种有效的方法。     

关于以能力建设为基础的培训工作研究

提高对人才能力建设的培训水平,是国有企业培训机构在人才培训工作与人力资源开发过程中需要深入研究、探索的重要课题。针对中国石油化工集团公司推进改革发展、实现企业战略目标对高级管理人才的需求,以企业高级管理人才任职前培训为目标,在培训需求研究、课程设计与内容开发、教学手段和方法、培训过程管理与质量保证机制、培训效果评估等方面进行研究。     

反转构造的反转程度及其与油气聚集的关系

结合典型反转构造地震剖面，分析了断层型和褶皱型两类反转构造的反转程度，上下皆正断层型和向形褶皱型反转构造的反转程度轻微；上逆下正断层型和透镜形褶皱型反转构造的反转程度中等；上下皆逆断层型和背形褶皱型反转构造的反转程度强烈。分析了反转构造的反转程度与油气聚集的关系，处于轻微反转程度的上下皆正断层型反转和向形褶皱型反转，以及处于强烈反转程度的上下皆逆断层型反转和背形褶皱型反转不利于油气聚集；处于中等反转程度的上逆下正断层型反转和透镜形褶皱型反转类型有利于油气聚集成藏。