DILIGENT: integrating digital library and Grid technologies for a new Earth observation research infrastructure

This paper introduces DILIGENT, a digital library infrastructure built by integrating digital library and Grid technologies and resources. This infrastructure allows different communities to dynamically build specialised digital libraries capable to support the entire e-Science knowledge production and consumption life-cycle by using shared computing, storage, content, and application resources. The paper presents some of the main software services that implement the DILIGENT system. Moreover, it exemplifies the provided features by presenting how the DILIGENT infrastructure is being exploited in supporting the activity of user communities working in the Earth Science Environmental sector. This work is partially funded by the European Commission in the context of the DILIGENT project, under the 2nd call of FP6 IST priority.     

Optoelectronic devices towards monolithic integration

Starting from the present state-of-the-art of discrete devices up to the realization of monolithic semiconductor integrated prototypes, an overview of optoelectronic devices for telecommunications is given. Among discrete devices single frequency lasers, tunable and multi-sectionDFB lasers andPIN andAPD photodiode detectors are analysed, including the use of new technologies in progress for a second generation of devices. On the future perspective ofIBCN distribution networks, some economics of the hybrid and monolithic form of integration are attempted. Finally a short outline of the most recent achievements in monolithic integration is presented, taking into particular consideration the activities in this field byEEC ESPRIT andRACE programmes.     

Degradation of lincomycin in aqueous medium: Coupling of solar photocatalysis and membrane separation

The photocatalytic oxidation of a common antibiotic, the lincomycin was carried out in aqueous suspensions of polycrystalline TiO₂ Degussa P25 irradiated by sunlight. In order to improve the performance of the lincomycin degradation a hybrid system consisting of a solar photoreactor with the photocatalyst in suspension coupled with a membrane module, used to confine both photocatalyst and pollutants in the reaction environment, was tested.A preliminary study was carried out in order to determine some kinetics parameters of the drug photodegradation. The influence of initial substrate concentration on the lincomycin photooxidation rate was investigated. The photooxidation rate follows a pseudo-first order kinetics with respect to the lincomycin concentration under the used experimental conditions. The presence of the membrane reactor allows the catalyst separation and to operate in continuous mode as the membranes rejection for lincomycin and its oxidation products was quite high.     

BRAF Gene and Melanoma: Back to the Future

As widely acknowledged, 40–50% of all melanoma patients harbour an activating BRAF mutation (mostly BRAF V600E). The identification of the RAS–RAF–MEK–ERK (MAP kinase) signalling pathway and its targeting has represented a valuable milestone for the advanced and, more recently, for the completely resected stage III and IV melanoma therapy management. However, despite progress in BRAF-mutant melanoma treatment, the two different approaches approved so far for metastatic disease, immunotherapy and BRAF+MEK inhibitors, allow a 5-year survival of no more than 60%, and most patients relapse during treatment due to acquired mechanisms of resistance. Deep insight into BRAF gene biology is fundamental to describe the acquired resistance mechanisms (primary and secondary) and to understand the molecular pathways that are now being investigated in preclinical and clinical studies with the aim of improving outcomes in BRAF-mutant patients.     

Hydrogen sorption sites in the gallium containing hybrid catalysts used for the aromatization of light alkanes

Gallium species which were incorporated initially in the oxide form, were all in the (+3) oxidation state in the hybrid catalyst and exhibited two types of hydrogen chemisorption sites, s_hw and s_hs. The stronger sorption sites shs which predominated at higher gallium dispersion, corresponded probably to the most effective surface configuration for gallium in the aromatization ofn-butane.     

THROO: a Tracked Hybrid Rover to Overpass Obstacles

In this paper, the design, simulation and experimental tests are presented for THROO: a Tracked Hybrid Rover, which has been developed to Overpass Obstacles. The proposed mobile robot has 3-DOFs and it is capable of straight motion, turning ability and two operations, namely rover-like motion with tracks on flat terrain and walking-like motion with track and legs to overpass obstacles to move on uneven terrain. The leg mechanism is composed of a four-bar linkage, which has been synthesized according to the desired features. In particular, the Burmester problem, which aims at finding the geometric parameters of a four-bar linkage required for a prescribed set of finitely separated poses are solved for the case understudy. Dynamic simulations have been carried out and a prototype has been built. The proposed results show the hybrid rover ability to overpass obstacles, for which size is comparable or greater than the track high.     

Manufacturing of polypropylene laminates and related structural reorganization in the crystalline phase

The conditions for obtaining recrystallization in more ordered modifications are described for an uniaxially oriented sample of isotactic polypropylene, annealed with fixed ends. These recrystallization conditions are related to the conditions of a lamination process.     

Privacy leakage on the Web: Diffusion and countermeasures

Protecting privacy on the Web is becoming increasingly complicated because of the considerable amount of personal and sensitive information left by users in many locations during their Web browsing and the silent actions of third party sites that collect data, aggregate information and build personal profiles of Internet users in order to provide free and personalized services. On the other hand, most of people are unaware that their information may be collected online, and that, after their aggregation from multiple sources, could be used for secondary purposes, such as linked to allow identification, without user’s notice.     

A vision towards Scientific Communication Infrastructures

The two pillars of the modern scientific communication are Data Centers and Research Digital Libraries (RDLs), whose technologies and admin staff support researchers at storing, curating, sharing, and discovering the data and the publications they produce. Being realized to maintain and give access to the results of complementary phases of the scientific research process, such systems are poorly integrated with one another and generally do not rely on the strengths of the other. Today, such a gap hampers achieving the objectives of the modern scientific communication, that is, publishing, interlinking, and discovery of all outcomes of the research process, from the experimental and observational datasets to the final paper. In this work, we envision that instrumental to bridge the gap is the construction of “Scientific Communication Infrastructures”. The main goal of these infrastructures is to facilitate interoperability between Data Centers and RDLs and to provide services that simplify the implementation of the large variety of modern scientific communication patterns.