Modeling trade-offs in the design of sensor-based event processing infrastructures

Systems for distributed event processing have recently gained increasing attention in a broad range of application domains. This raises the demand for methods to adapt the system design to application-specific needs. Our approach considers (1) trade-offs regarding the hardware infrastructure and (2) trade-offs in the software design. For the underlying model we categorize events along the dimensions of temporal complexity and physical distribution. This yields a categorization of events that drives trade-offs in the infrastructure design. The presented model supports design decisions in dependence on application-specific event properties and design goals.     

Mapgets: A Tool for Visualizing and Querying Geographic Information

Although geographic applications vary widely, their user interfaces have many requirements in common because of the spatial component of their data. Geographic data are not standard data, and appropriate tools are required (i) for editing (i.e. displaying and modifying) and (ii) for querying them. In this paper, we first study the major aspects of visualizing and querying geographic information within a database management system (DBMS) and their impact on the design of graphical geographic database user interfaces (GDUIs). We then present a map editing and querying model as well as general GDUI architecture. Both rely on the concept of the mapget (map widget), a mediator for manipulating geographic information interactively.     

A System for Change Documentation Based on a Spatiotemporal Database

The evolution of geographic phenomena has been one of the concerns of spatiotemporal database research. However, in a large spectrum of geographical applications, users need more than a mere representation of data evolution. For instance, in urban management applications—e.g., cadastral evolution—users often need to know why, how, and by whom certain changes have been performed as well as their possible impact on the environment. Answers to such queries are not possible unless supplementary information concerning real world events is associated with the corresponding changes in the database and is managed efficiently. This paper proposes a solution to this problem, which is based on extending a spatiotemporal database with a mechanism for managing documentation on the evolution of geographic information. This solution has been implemented in a GIS-based prototype, which is also discussed in the paper.     

An Ontology-Based Approach to Personalized Situation-Aware Mobile Service Supply

Mobile devices such as personal digital assistants (PDAs) and mobile phones are in widespread use already today and converging to mobile smart phones. They enable users to access a wide range of services and information without guidance through their actual demands. Especially during mass events like the Olympic Games 2008 in Beijing—which was initially the context of our work—a large service space is expected to support all mobile visitors, being athletes, journalists, or spectators. Current approaches tackling such problems are location based, meaning that a user's location is central to service provision, and even context-aware, meaning that, beyond location, characteristics of a user's environment are taken into account. Such information obviously helps to deliver relevant information at the right time to the mobile users. Going one step further, a situation-aware system abstracts from the context dimensions by translating specific contexts into logical situations. Knowing the situation end users are in allows the system to better identify the information to be delivered to them and to choose the appropriate services with regard to their scope, which is referred to as service roaming. Even though many context frameworks have been introduced in the past few years, what is usually missing is the notion of characteristic features of contexts that are invariant during certain time intervals. This paper presents these concepts in the context of a platform development, namely FLAME2008, which is able to support its mobile users with personalized situation-aware services in push and pull mode.     

Manufacturing Solid Oxide Fuel Cells for the Sulzer Hexis Stationary System

Concomitantly to its main objective of cost reduction per electrical kilowatt of stationary fuel cell stacks, Sulzer Hexis Ltd. (Switzerland) is developing the first commercial cogeneration solid oxide fuel cell system (SOFC) available on the market. This will be possible by fine technology optimization combined with using mass-production compatible equipment. After several years of R&D in ceramic processing techniques, Sulzer Hexis is now able to manufacture solid oxide fuel cells with competitive production costs. Moreover, these costs will be further reduced thanks to scale effect given by large production volumes. The tight collaboration with both raw material and equipment suppliers has enabled Sulzer Hexis to significantly improve both the cell performance and productivity.     

Estradiol concentrations in premenopausal women with coronary heart disease

BACKGROUND: Because of the beneficial effects of estrogen, premenopausal women are normally protected against coronary heart disease (CHD) and are at lower risk for myocardial infarction; consequently, CHD occurs very rarely in menstrually active women. Given this background, the aim of the present study was to test the hypothesis that decreased concentrations of estrogen are associated with CHD in premenopausal women. METHODS: Fourteen premenopausal women with CHD were investigated and compared with a healthy control group comparable for age and cardiovascular risk factors. Relevant characteristics of patients and controls were assessed: age, blood pressure, body mass index, total cholesterol and high-density lipoprotein cholesterol, triglycerides, former pregnancies, ovariectomy and related surgical interventions, smoking history and former use of oral contraceptives. To ensure the premenopausal status of the participants, the regularity of the menstrual cycle and the follicle-stimulating hormone concentrations were also assessed. Plasma estradiol and progesterone and urine estrone concentrations (24 h urine collection) were measured at day 6 after estimated ovulation to assess the relative increase in plasma estradiol and progesterone during the second half of the menstrual cycle. RESULTS: Compared with the control group, premenopausal women with CHD had significantly lower concentrations of plasma estradiol (408.9 +/- 141 pmol/l and 287.8 +/- 109 pmol/l respectively; P = 0.0228) and total estrogen (2061 +/- 693 pg/mumol creatinine and 1607 +/- 448 pg/mumol creatinine respectively; P = 0.025) in the urine. However, the progesterone concentrations were not significantly different between the groups. These findings might be explained by a partial ovarian dysfunction, as the patient group had a significantly higher number of tubal sterilizations (eight compared with one). CONCLUSION: Our data provide support for the hypothesis that decreased concentrations of estradiol might be an additional pathogenetic factor for the development of CHD in menstrually active premenopausal women.     

High-dose diltiazem prevents migration and proliferation of vascular smooth muscle cells in various in-vitro models of human coronary restenosis

BACKGROUND: Restenosis after coronary angioplasty is considered to be caused mainly by increased migration and proliferation of smooth muscle cells (SMC). The concept of local, site-specific delivery of pharmacologic therapies has opened the door for new, high-dose drug regimes. METHODS AND RESULTS: SMC were isolated by enzymatic disaggregation with collagenase/elastase from human coronary plaque tissue of 29 patients (pSMC) and post mortem from the coronary media of 33 corpses (mSMC). Endothelial cells were isolated from human umbilical veins by enzymatic disaggregation with collagenase/dispase. By positive reaction with antibodies against smooth muscle alpha-actin and von Willebrand factor cells were identified as SMC or endothelial cells. In proliferation studies 5-150 micrograms/ml diltiazem was added to the culture media of pSMC, mSMC and endothelial cells. After 5 days there was a significant dose-dependent inhibition of cell proliferation (for pSMC with > 50 micrograms/ml, for mSMC with > 25 micrograms/ml, and for endothelial cells with > 5 micrograms/ml). In migration studies the effect of 5-150 micrograms/ml diltiazem on the velocity of migration of pSMC was investigated over a period of 48 h. Administration of diltiazem at concentrations of 100 and 150 micrograms/ml caused a significant inhibition of the migration of pSMC. The cytoskeletal components smooth muscle alpha-actin, vimentin, and alpha-tubulin of pSMC and the expression of von Willebrand factor of endothelial cells were investigated after an incubation period of 5 days with 50 and 150 micrograms/ml diltiazem. In the transfilter coculture model the effect of 50 micrograms/ml diltiazem on mSMC was investigated after mechanical injury of cocultured endothelial cells. Administration of diltiazem at a concentration of 50 micrograms/ml inhibited the development of a neointimal proliferate in the transfilter coculture model significantly (P < 0.001). CONCLUSIONS: A high dose of diltiazem inhibited the migratory and proliferative activities of coronary SMC significantly. In further experimental studies the effect of locally applied high doses of diltiazem on postangioplasty restenosis should be elucidated.     

Expression of intercellular adhesion molecule-1 in human coronary endothelial and smooth muscle cells after stimulation with tumor necrosis factor-alpha

BACKGROUND: The intercellular adhesion molecule-1 (ICAM-1) is one of several human cell adhesion molecules that play a critical role in the early stages of postangioplasty restenosis. In this study, the in-vitro expression of ICAM-1 in human coronary endothelial cells and human coronary smooth muscle cells (SMC) after stimulation with tumor necrosis factor-alpha (TNF-alpha) was investigated. METHODS AND RESULTS: SMC were isolated from the media of normal human coronary arteries (n = 26) up to 10 h post mortem (HCMSMC) and from human atherosclerotic coronary arteries (HCPSMC) that were extracted by thrombendarterectomy (n = 25). Endothelial cells of human coronary arteries (HCAEC) were purchased from Clonetics (Cell System, Remagen, Germany), and endothelial cells from human umbilical cord veins (HUVEC) were isolated after vaginal delivery. For investigations of the effect of TNF-alpha (2.5, 5, 10, and 20 ng/ml) on the proliferative activity of HUVEC, HCAEC, HCPSMC, and HCMSMC, serum-free media was used. After 24 h cell number and cell size distribution were measured in a cell analyzer system. The proliferation of HCPSMC and HCMSMC was increased by TNF-alpha; however, significant differences compared with controls were not reached. The proliferation of HUVEC and HCAEC was significantly reduced by TNF-alpha. For investigations of the effect of TNF-alpha (2.5, 5, 10, and 20 ng/ml) on the surface expression of ICAM-1, monoclonal anti-ICAM-1 antibodies (84H10) were used. The expression of ICAM-1 was analyzed using an immunofluorescence microscope. For flow cytometry analysis, 5 x 10(3) cells (100% gated) were analyzed using a fluorescence-activated cell sorter. In control cultures with no stimulation, the expression of ICAM-1 was positive in HCAEC, HCPSMC, HCMSMC, and HUVEC. TNF-alpha stimulated the expression of ICAM-1 in a time- and dose-dependent manner. After maximal stimulation with TNF-alpha (20 ng/ml for 24 h), the expression of ICAM-1 was stronger in HCMSMC than in HCPSMC. CONCLUSIONS: These results suggest that the cytokine TNF-alpha regulates the expression of ICAM-1 in both human coronary endothelial cells and SMC, and could therefore play an important role in the pathophysiology of inflammatory and immune processes in restenosis after angioplasty.     

The in-vitro effect of antineoplastic agents on proliferative activity and cytoskeletal components of plaque-derived smooth-muscle cells from human coronary arteries

BACKGROUND: Restenosis after successful percutaneous transluminal coronary angioplasty remains the major clinical problem limiting the long-term efficacy of the treatment. Recent advances in the understanding of the biology of restenosis indicate that its cause is predominantly a multifactorial stimulation of smooth-muscle cell proliferation. The aim of this study was to investigate the in-vitro effect of antineoplastic agents on smooth-muscle cells isolated from human coronary plaque material. METHODS: Atherosclerotic tissue from coronary arteries was extracted from 15 patients of both sexes by thrombendarterectomy. Cells were isolated using enzymatic disaggregation and identified to be smooth-muscle cells with fluorescent antibodies for smooth-muscle-specific alpha-actin. The antineoplastic agents cytarabine (500-0.005 micrograms/ml), doxorubicin (50-0.0005 micrograms/ml), and vincristine (10-0.0001 micrograms/ml) were added to the cultures. Six days after seeding, the cells were trypsinized and then counted. RESULTS: All three antineoplastic agents had a strong dose-dependent antiproliferative effect on cultured smooth-muscle cells. After the application of cytostatic agents, cells either became rounded or underwent complete lysis. Cytoskeletal elements, such as actin, microtubules, and vimentin, were largely altered. CONCLUSION: This investigation examined the potential role of antineoplastic therapy in the prevention of restenosis after coronary angioplasty. The development of new intravascular delivery systems, such as coated stents, may open the way for local antiproliferative strategies in interventional cardiology.