BELL OASIS(R)纤维的特性与开发应用

介绍了日本钟纺公司开发的多用途BELL OASIS 纤维.该纤维结构独特,具有极强的吸水性和吸湿性,可与其他纤维按不同比例混合,并适用于多种非织造布制造工艺,应用领域广泛.     

BELL OASIS纤维的特性与开发应用

介绍了日本钟纺公司开发的多用途BELLOASIS纤维。该纤维结构独特 ,具有极强的吸水性和吸湿性 ,可与其他纤维按不同比例混合 ,并适用于多种非织造布制造工艺 ,应用领域广泛     

Expression of DDX11 and DNM1L at the 12p11 Locus Modulates Systemic Lupus Erythematosus Susceptibility

Objectives: This study employed genetic and functional analyses using OASIS meta-analysis of multiple existing GWAS and gene-expression datasets to identify novel SLE genes. Methods: Four hundred and ten genes were mapped using SNIPPER to 30 SLE GWAS loci and investigated for expression in three SLE GEO-datasets and the Cordoba {"type":"entrez-geo","attrs":{"text":"GSE50395","term_id":"50395"}}GSE50395-dataset. Blood eQTL for significant SNPs in SLE loci and STRING for functional pathways of differentially expressed genes were used. Confirmatory qPCR on SLE monocytes was performed. The entire 12p11 locus was investigated for genetic association using two additional GWAS. Expression of 150 genes at this locus was assessed. Based on this significance, qPCRs for DNM1L and KRAS were performed. Results: Fifty genes were differentially expressed in at least two SLE GEO-datasets, with all probes directionally aligned. DDX11, an RNA helicase involved in genome stability, was downregulated in both GEO and Cordoba datasets. The most significant SNP, rs3741869 in OASIS locus 12p11.21, containing DDX11, was a cis-eQTL regulating DDX11 expression. DDX11 was found repressed. The entire 12p11 locus showed three association peaks. Gene expression in GEO datasets identified DNM1L and KRAS, besides DDX11. Confirmatory qPCR validated DNM1L as an SLE susceptibility gene. DDX11, DNM1L and KRAS interact with each other and multiple known SLE genes including STAT1/STAT4 and major components of IFN-dependent gene expression, and are responsible for signal transduction of cytokines, hormones, and growth-factors, deregulation of which is involved in SLE-development. Conclusion: A genomic convergence approach with OASIS analysis of multiple GWAS and expression datasets identified DDX11 and DNM1L as novel SLE-genes, the expression of which is altered in monocytes from SLE patients. This study lays the foundation for understanding the pathogenic involvement of DDX11 and DNM1L in SLE by identifying them using a systems-biology approach, while the 12p11 locus harboring these genes was previously missed by four independent GWAS.     

A numerical approach for planning offshore wind farms from regional to local scales over the Mediterranean

Renewable energy resources, such as wind, are available worldwide. Locating areas with high and continual wind sources are crucial in pre-planning of wind farms. Vast offshore areas are characterized by higher and more reliable wind resources in comparison with continental areas. However, offshore wind energy production is in a quite preliminary phase. Elaborating the potential productivity of wind farms over such areas is challenging due to sparse in situ observations. The Mediterranean basin is not an exception. In this study we are proposing numerical simulations of near-surface wind fields from regional climate models (RCMs) in order to obtain and fill the gaps in observations over the Mediterranean basin. Four simulations produced with two regional climate models are examined here. Remote sensing observations (QuikSCAT satellite) are used to assess the skill of the simulated fields. A technique for estimating the potential energy from the wind fields over the region is introduced. The wind energy potential atlas and the map of a wind turbine's functional range are presented, locating the potentially interesting sub-regions for wind farms. The ability of models to reproduce the annual cycle and the probability density function of wind speed anomalies are detailed for specified sub-regions.     

气候系统模式耦合器的研究与发展

基于耦合器的模块化框架结构是当今气候系统模式发展的主要技术方向。概述了气候系统模式耦合器的发展背景,着重介绍了两种典型的耦合器,并在软件结构和耦合功能两个方面对它们进行比较分析,最后讨论了气候系统模式耦合器的发展方向。     

Levels of aflatoxin M1 in different types of milk collected in Serbia: Assessment of human and animal exposure

The level of aflatoxin M1 (AFM1) in 50 milk samples collected from February to June 2013 from Serbian market or domestically produced was determined using simple non-specific sample preparation method based on solid phase extraction (Oasis HLB, Waters) and ultra-high performance liquid chromatography with heated electrospray ionization triple quadrupole mass spectrometry (UHPLC/HESI-MS/MS). The range of detection was between < LOD and 1.44 μg/kg with mean value of 0.30 μg/kg. Thirty-eight samples (76%) exceed the maximum level of 0.05 μg/kg sets by EU. The highest level of 1.44 μg/kg was found in raw sample of domestically produced milk while the lowest one in organic produced milk. The evaluation of the exposure degree of AFM1 through the milk consumption by the average Serbian citizen was estimated at levels of 1.420, 0.769 and 0.503 ng/kg bw/day during February, April and May, respectively. Estimation of the corresponding concentration of AFB1 in feedstuffs was evaluated as 18.75 μg/kg. The calculated hazard index of 7.1, 3.8 and 2.5 for February, April and May, respectively, was higher than 1 indicated serious risk of AFM1 to Serbian consumers. This work presents the first insight in the occurrence of AFM1 in milk collected in Serbia as well as mycotoxin intake through milk consumption by Serbian adult population.     

3D迁移网络的阿尔茨海默症分类研究

阿尔兹海默症目前还无法被治愈,若能对其正确诊断,则可采用正确治疗方式延缓病人病情。为减少人工诊断的时间和成本,采用机器学习方法来辅助人工诊断阿尔兹海默症,提出了一种利用3D核磁共振成像信号来诊断的迁移学习方法。该方法采用MobileNet迁移网络来提取瓶颈特征,并增加了一个有监督训练的顶层来进一步降维和提取特征,最后在分类层中将被试者所有切片的特征进行合并和训练,完成阿尔兹海默症与正常控制的分类。该方法的优点在于,可使网络的训练时间下降,提高分类准确率。实验采用了OASIS数据对该方法进行测试,结果表明,该方法的分类准确率比传统迁移学习网络提高了约8个百分点,而时间只有传统迁移方法的1/60。     

中国实验快堆动态模拟系统的建立

为了运用快系统安全分析程序ＯＡＳＩＳ对中国实验快堆进行安全和计算,初步建立了ＣＥＦＲ动态模拟系统。该系统将应用于ＣＥＦＲ的初步安全分析并将用来对ＣＥＦＲ的控制保护系统进行动态仿真研究。     

CEFR非对称运行工况的研究

为研究中国实验快堆（CEFR）非对称运行工况,通过快堆系统安全分析程序OASIS及堆芯子通道分析程序COBRA对CEFR单环路运行时堆内的温度以及流量进行了计算。结果表明,CEFR在单环路运行,完好环路一、二次钠泵转速为500 r/min,且事故环路一次钠泵逆止阀开启时,堆芯最多开启在14%的功率水平,以确保反应堆处于安全状态。     

OASIS程序的开发与应用

全面描述了对来自法国原子能委员会 (简称CEA)的快堆系统安全分析程序OASIS的引进和开发工作 ,并在此基础上介绍了该程序在中国实验快堆 (ChinaExperimentalFastReactor,简称CEFR)初步安全分析报告中对主给水管道断裂事故的分析计算。