What Can We Learn from FGF-2 Isoform-Specific Mouse Mutants? Differential Insights into FGF-2 Physiology In Vivo

Fibroblast growth factor 2 (FGF-2), ubiquitously expressed in humans and mice, is functionally involved in cell growth, migration and maturation in vitro and in vivo. Based on the same mRNA, an 18-kilo Dalton (kDa) FGF-2 isoform named FGF-2 low molecular weight (FGF-2LMW) isoform is translated in humans and rodents. Additionally, two larger isoforms weighing 21 and 22 kDa also exist, summarized as the FGF-2 high molecular weight (FGF-2HMW) isoform. Meanwhile, the human FGF-2HMW comprises a 22, 23, 24 and 34 kDa protein. Independent studies verified a specific intracellular localization, mode of action and tissue-specific spatiotemporal expression of the FGF-2 isoforms, increasing the complexity of their physiological and pathophysiological roles. In order to analyze their spectrum of effects, FGF-2LMW knock out (ko) and FGF-2HMWko mice have been generated, as well as mice specifically overexpressing either FGF-2LMW or FGF-2HMW. So far, the development and functionality of the cardiovascular system, bone formation and regeneration as well as their impact on the central nervous system including disease models of neurodegeneration, have been examined. This review provides a summary of the studies characterizing the in vivo effects modulated by the FGF-2 isoforms and, thus, offers a comprehensive overview of its actions in the aforementioned organ systems.     

隐蔽老火区立体式综合治理研究

对2320隐蔽老火区首先通过灌注泥浆对火区进行治理,同时对部分裂隙通道进行堵漏,然后对泥浆不能到达的区域注入高倍数三相泡沫灭火材料泡沫,瞬间将火源处覆盖,火源因隔绝氧气而窒息灭火。三相泡沫具有良好的堆积性和流动性,对煤体具有保水保湿,惰化遗煤氧化空间,并能够对松散煤体进行化学阻化,从本质上降低遗煤自然氧化速率,消灭了隐蔽老火区的火灾隐患,具有较高的推广价值。     

Cu基络合物催化甲醇液相氧化羰化反应

针对甲醇液相氧化羰基化法合成碳酸二甲酯(DMC)工艺,开发了新型Cu基络合催化剂(CuB rnLm)。对CuB rnLm催化剂的活性及其稳定性进行了研究。实验结果表明,采用该催化剂,甲醇转化率和DMC选择性较高;元素价态和物质结构分析表明,CuB rnLm催化剂循环使用5次后仍保持较好的稳定性。采用正交设计和中心响应曲面法设计实验,并使用S tatistica软件进行统计分析,寻求出反应的主要影响因素,并得到优化的工艺条件:反应温度100~110℃、反应压力3.0~3.5M Pa、反应时间4~6h、CuB rnLm催化剂质量浓度(以甲醇的体积计)0.15~0.20g/mL。在此工艺条件下,甲醇转化率可达23%以上,DMC的选择性为96%~98%。     

浅析高校新校区选址主要影响因素

从政策、城市与区域规划、环境、文化及其传承因素、基础设施等方面探析了高校新校区选址有关的主要影响因素，以满足高等学校大规模的扩建要求，促进高等教育的发展。     

住宅设计的分析与研究

总结了住宅设计的发展,概括了住宅各个功能区的特点。通过设计的实例说明了各不同功能区的设计,成果可供进一步的研究参考。     

晋北吕梁群石榴石的特征及指示意义

石榴石是山西岚县袁家村一带-娄烦县出露的吕梁群地层中主要的特征变质矿物，其次为黑云母、十字石等，对这些特征变质矿物进行电子探针的成分分析及其相关计算，并利用不同采样点的矿物对估算该点变质温度和压力，最后得到石榴石的成分变化与变质程度之间的关系，进而阐明了石榴石中成分变化对变质温度与压力的指示意义。     

现代住区规划的几点思考

通过对居住区规划中住区交通组织、环境建设,以及住宅配套现实处理方法的分析,指出现代住区的规划要根据当地实际情况,因地制宜组织住区交通网络,合理整合住宅内外环境,适度超前建设配套设施。     

Modelling the impact of energy taxation

Energy taxation in Sweden is complicated and strongly guides and governs district energy production. Consequently, there is a need for methods for accurate calculation and analysis of effects that different energy tax schemes may have on district energy utilities. Here, a practicable method to analyse influence of such governmental policy measures is demonstrated. The Swedish Government has for some years now been working on a reform of energy taxation, and during this process, several interest groups have expressed their own proposals for improving and developing the system of energy taxation. Together with the present system of taxation, four new alternatives, including the proposed directive of the European Commission, are outlined in the paper. In a case study, an analysis is made of how the different tax alternatives may influence the choice of profitable investments and use of energy carriers in a medium‐sized district‐heating utility. The calculations are made with a linear‐programming model framework. By calculating suitable types and sizes of new investments, if any, and the operation of existing and potential plants, total energy costs are minimized. Results of the analysis include the most profitable investments, which fuel should be used, roughly when during a year plants should be in operation, and at what output. In most scenarios, the most profitable measure is to invest in a waste incineration plant. However, a crucial assumption is, with reference to the new Swedish waste disposal act, a significant income from incinerating refuse. Without this income, different tax schemes result in different technical solutions being most profitable. An investment in cogeneration seems possible in only one scenario. It is also found that particular features of some alternatives seem to oppose both main governmental policy goals, and intentions of the district heating company. Copyright © 2002 John Wiley & Sons, Ltd.     

中关村中心区水文地质及工程地质特征

本文全面、系统地分析了北京市中关村中心区的水文地质及工程地质特征 ,为该地区的工程建设提供可靠的地质资料     

柴达木盆地断裂系统特征与油气勘探战略方向

基底断裂格局决定了盆地构造演化和沉积发育,导致了北缘、中部和昆北3个各具特色的断裂构造系统。北缘断裂构造系统平面上以反S展布、剖面上以一系列北倾南冲的逆冲断层带及其所控制的同沉积构造呈阶梯向南下掉为特点,受北部祁连山构造应力系统的作用;南部昆北断裂构造系统发育压陷断槽和断阶带,受南部昆仑山构造应力系统的作用;中部断裂构造系统以两断夹一隆的冲起构造为特色,同时受祁连山和昆仑山构造应力的共同作用。断裂对油气藏的形成和分布有重要的控制作用,表现在对烃源岩、储集条件、圈闭形成及油气运聚等方面。依据断裂控烃特征并针对柴达木盆地的具体情况,柴达木盆地油气勘探应迅速转移到盆地腹地即中部断裂构造系统区,尤其是鄂博梁Ⅱ号一伊克雅乌汝、鸭湖—台吉乃尔构造带和中南隆起区,有望取得重大突破。