In Vivo Albumin-Binding of a C-Functionalized Cyclam Platform for 64Cu-PET/CT Imaging in Breast Cancer Model

An improved glucose-chelator-albumin bioconjugate (GluCAB) derivative, GluCAB-2^Mal, has been synthesized and studied for in vivo ⁶⁴Cu-PET/CT imaging in breast cancer mice models together with its first-generation analogue GluCAB-1^Mal. The radioligand works on the principle of tumor targeting through the enhanced permeability and retention (EPR) effect with a supportive role played by glucose metabolism. [⁶⁴Cu]Cu-GluCAB-2^Mal (99 % RCP) exhibited high serum stability with immediate binding to serum proteins. In vivo experiments for comparison between tumor targeting of [⁶⁴Cu]Cu-GluCAB-2^Mal and previous-generation [⁶⁴Cu]Cu-GluCAB-1^Mal encompassed microPET/CT imaging and biodistribution analysis in an allograft E0771 breast cancer mouse model. Tumor uptake of [⁶⁴Cu]Cu-GluCAB-2^Mal was clearly evident with twice as much accumulation as compared to its predecessor and a tumor/muscle ratio of up to 5 after 24 h. Further comparison indicated a decrease in liver accumulation for [⁶⁴Cu]Cu-Glu-CAB-2^Mal.     

AT91SAM7S64芯片I2C(TWI)接口应用开发

较为详细地介绍AT91SAM7S64芯片的I2C接口控制器中外围数据控制器(PDC)的使用方式,并将其与AT24C04之间的通信作为实例给出完整的应用开发流程和软硬件详细描述。该方法的可行性已经为工程实践和实际产品所证实。该操作也可推广到其他AT91SAM7S系列ARM处理器与其他I2C接口器件间的通信。并对其他拥有外围数据控制器的接口开发有一定的借鉴意义。     

Copper bioavailability from breakfasts containing tea. Influence of the addition of milk

The influence of drinking tea on copper bioavailability is unclear, particularly when tea is consumed with food. A breakfast meal containing white bread, margarine, strawberry jam, cheese and tea, with or without milk, was digested in; vitro and the dialysis of copper investigated. Reference breakfasts were prepared with water and water with milk. Copper dialysability (percentage of copper dialysed) was markedly increased by tea. The influence of adding milk to tea was not significant. A second study was carried out in rats using the breakfasts containing tea and water. They were spiked with ⁶⁴Cu and given orally to the animals in a single dose. Whole-body ⁶⁴Cu retention was measured over a 4-day period after administration. In order to determine the true absorption of ⁶⁴Cu a control group of rats received the dose intraperitioneally. The results in vivo indicate a tendency to higher absorption and retention of ⁶⁴Cu with tea. Liver ⁶⁴Cu retention was significantly elevated by tea. Therefore, the presence of tea in a breakfast meal favours the formation of soluble low-molecular-weight ligands which can be absorbed and retained by rats. The concomitant increase in liver copper retetition may be associated with higher bioavailability and/or lower copper mobilisation.     

Tru64 Unix服务器中系统及进程信息的获取方法

介绍了通过访问/proc伪文件系统,获得Tru64操作系统系统的进程信息的方法,以及根据所取得的数据计算进程CPU占用率和内存等信息的算法。还介绍了通过Tru64系统特有的API函数获得系统信息的方法。并对基于此方法取得的试验数据与top、SystemInformation、ProcessTuner的数据作比较。     

基于C#语言的图片插入方法比较

图片是传递与表达信息的重要形式,由于图片数据特殊编码方式,它的存储和显示显得比较复杂。C#功能强大,使用方便,已经成为一种主流的计算机软件编程语言。文章介绍了使用C#向数据库中插入图片的方法,并加以比较。     

Tilepro64多核处理器的软件无线电平台构建

以Tilepro64多核处理器为核心,设计了面向无线信号数据采集处理的软件无线电系统平台。无线中频信号通过以FPGA为核心的模拟前端的放大、滤波和下变频等处理,进入基于Tilepro64处理器的数字处理模块,经过解调和解码等步骤,将信息由XAUI接口传往上位机。     

基于MC9S12NE64的以太网测控系统的设计

嵌入式测控系统是当前工业自动化测控应用领域研究的热点之一。本文利用Freescale公司的MC9S12NE64MCU,运用其内部10位A/D模块,进行数据采集,并通过其集成的以太网网络模块实现了数据上传和远程控制。