基于有限元分析的连铸机钢包回转台结构优化设计

本文利用先进的ANSYS工程分析软件对连铸机钢包回转台进行有限元分析,找出整个回转台的应力和变形的分布情况,分析出回转台的薄弱环节,并在有限元分析的基础上进行优化设计,使得优化后的回转台结构在刚度和强度上都有很大提高,从而有针对性地解决了工程实际问题.     

基于Von Mises应力的预应力钢结构拓扑优化设计

为预应力钢结构设计获得最优拓扑构型和索力值,以结构拓扑和索力值为设计变量,以Von Mises应力为约束条件,建立了以结构质量最小为目标函数的数学优化模型.在求解方法上,首先以结构储存应变能最小(刚度最大)确定施加在结构上的索力值,然后采用渐进结构优化法删除低Von Mises应力单元实现结构的拓扑优化以减轻结构质量.算例结果与相应体系受力性能相吻合.     

Mechanical behaviour analysis of buried pressure pipeline crossing ground settlement zone

Numerical simulation model of buried pipeline crossing ground settlement zone was established considering pipeline–soil interaction. Mechanical behaviour of the buried pipeline was investigated, and effects of ground settlement, pipeline parameters and surrounding soil parameters on mechanical behaviour of the buried pipeline were discussed. These results show that there are two high stress areas on both sides of the dividing plane. High stress areas are oval on the top and bottom of the pipeline. Z-shape bending deformation appears under the action of ground settlement. In ground settlement zone, axial strain on the top of the pipeline is compression strain, and axial strain on the bottom of the pipeline is tension strain. On the contrary, they are tension strain and compression strain respectively in no settlement zone. Bending deformation, axial strain and plastic strain of the buried pipeline increase with the increase in ground settlement. Von Mises stress, high stress area, axial strain and plastic strain of the buried pipeline increase with the increasing diameter-thick ratio and internal pressure, but they decrease with the increase in buried depth. Diameter-thick ratio and internal pressure have a small effect on the bending deformation of the buried pipeline. Bending deformation decreases with the increase in buried depth in ground settlement zone. Von Mises stress and high stress area increase with the increasing surrounding soil’s elasticity modulus and cohesion, but they increase first and then decrease with the increase in Poisson’s ratio. Bending deformation of the pipeline in no settlement zone increases with the increase in elasticity modulus and Poisson’s ratio, but it is affected little by the cohesion. Axial strain and plastic strain have a bigger relationship with the elasticity modulus and Poisson’s ratio. Axial strain and plastic strain of the buried pipeline increase with the increase in cohesion, and the change rates increase with the increase in ground settlement.     

基于冯•诺依曼邻域结构的人工鱼群算法

提出了一种基于冯¢ 诺依曼邻域结构的人工鱼群算法. 每条人工鱼只和与自己相连的上下左右的人工鱼进行信息交换, 从而减少了计算邻域中心位置和极值位置的计算量, 有效地维持了种群的多样性, 加快了算法的运行速度. 在觅食行为中, 人工鱼通过直接移动到搜索到的较好位置, 来加快搜索速度. 在随机游动行为中, 人工鱼以小半径进行搜索, 因此算法的优化精度得到了提高. 采用动态调整人工鱼视野和步长的方法, 较好地平衡了全局搜索能力和局部搜索能力. 仿真和实例计算结果表明, 该算法具有更好的优化性能.     

无限维两体量子系统可分态的一个必要充分条件

构造所考虑的量子系统与辅助量子系统张量积空间中的经典态,利用经典态在辅助复合系统的偏迹运算,研究了无限维两体复合量子系统态纠缠的识别问题,得出了无限维两体复合量子系统态可分的一个必要充分条件,推广了Li Nan和Luo Shunlong的有限维复合量子系统的相关结果.对于识别无限维量子态的纠缠或可分是一个补充.     

零边界条件下二维元胞自动机矩阵可逆性分析

该文介绍了二维元胞自动机的典型邻域结构,对多状态二维元胞自动机的矩阵描述进行了拓展.通过对零边界条件下元胞自动机的状态转移矩阵的块矩阵的分析,得出矩阵的可逆性与元胞自动机冯诺依曼型邻域之间的联系.     

Color balancing of digital photos using simple image statistics

The great diffusion of digital cameras and the widespread use of the internet have produced a mass of digital images depicting a huge variety of subjects, generally acquired by unknown imaging systems under unknown lighting conditions. This makes color balancing, recovery of the color characteristics of the original scene, increasingly difficult. In this paper, we describe a method for detecting and removing a color cast (i.e. a superimposed color due to lighting conditions, or to the characteristics of the capturing device), from a digital photo without any a priori knowledge of its semantic content. First a cast detector, using simple image statistics, classifies the input images as presenting no cast, evident cast, ambiguous cast, a predominant color that must be preserved (such as in underwater images or single color close-ups) or as unclassifiable. A cast remover, a modified version of the white balance algorithm, is then applied in cases of evident or ambiguous cast. The method we propose has been tested with positive results on a data set of some 750 photos.     

采用不同的动力学模型对比研究扁平加劲薄壳结构的临界状态

目前大多采用Kantorovich逼近算法研究棱柱形平板和加劲薄壳结构的屈曲应力,该方法参考了Von Karman和Koiter-Sanders理论,当预测的屈曲模态涉及平面内和平面外位移的比较时,后者引入了Green-Lagrange应变张量的概念。此外,为了突出Koiter-Sanders模型的非线性特性,进一步考虑了两个中间模型,根据不同的理论方法选择了改进的Von Karman模型和伪似然模型,以简化数值计算。结果表明,至少从实用的角度看来,在所选择的3个模型的计算结果基本相同的条件下,在不能忽视平面内位移的屈曲问题中,Von Karman模型过高地估计了临界荷载。     

Zafirlukast Induces VHL- and HIF-2α-Dependent Oxidative Cell Death in 786-O Clear Cell Renal Carcinoma Cells

Mutations in the Von Hippel–Lindau (VHL) gene are the driving force in many forms of clear cell renal cell carcinoma (ccRCC) and promote hypoxia-inducible factor (HIF)-dependent tumor proliferation, metastasis and angiogenesis. Despite the progress that has already been made, ccRCC generally remain resistant to conventional therapies and ccRCC patients suffer from metastasis and acquired resistance, highlighting the need for novel therapeutic options. Cysteinyl leukotriene receptor 1 (CysLTR1) antagonists, like zafirlukast, are administered in bronchial asthma to control eicosanoid signaling. Intriguingly, long-term use of zafirlukast decreases cancer risk and leukotriene receptor antagonists inhibit tumor growth, but the mechanisms still remain unexplored. Therefore, we aim to understand the mechanisms of zafirlukast-mediated cell death in ccRCC cells. We show that zafirlukast induces VHL-dependent and TNFα-independent non-apoptotic and non-necroptotic cell death in ccRCC cells. Cell death triggered by zafirlukast could be rescued with antioxidants and the PARP-1 inhibitor Olaparib, and additionally relies on HIF-2α. Finally, MG-132-mediated proteasome inhibition sensitized VHL wild-type cells to zafirlukast-induced cell death and inhibition of HIF-2α rescued zafirlukast- and MG-132-triggered cell death. Together, these results highlight the importance of VHL, HIF and proteasomal degradation in zafirlukast-induced oxidative cell death with potentially novel therapeutic implications for ccRCC.