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1.
为了系统地评价胸腺五肽作为辅助药物治疗各种肺癌的疗效及其对机体免疫功能的影响,利用电子检索收集有关胸腺五肽联合放疗或化疗方案治疗肺癌的临床随机对照试验文献,对符合纳入标准的文献,采用RevMan5.3 软件进行系统评价。最终共纳入文献 9 篇,总样本量 784 例。Meta 分析结果表明,胸腺五肽作为辅助药物治疗各种肺癌提高总有效率的差异无统计学意义[OR = 1.44, 95%CI(0.99, 2.10), P =0.06 > 0.05]。在对免疫功能的影响方面,胸腺五肽的使用显著增高外周血中的 CD3+ 细胞水平[OR = 5.88, 95% CI(2.34, 9.42), P =0.001],CD4+ 细胞水平也显著上升[OR =8.32, 95%CI(5.22, 11.42), P < 0.00001] , CD4+ /CD8+比值也有明显的提高[OR = 0.38, 95% CI(0.18, 0.59), P=0.0002],但 CD8+ 细胞水平的差异无统计学意义[OR =-3.12, 95% CI ( -9.02, 2.79), P >0.05]。总的来说,本研究在一定程度上反映了在辅助治疗肺癌方面,胸腺五肽能显著提高外周血中的 CD3+ 细胞水平、CD4+ 细胞水平、CD4+/CD8+ 比值。而对于治疗的有效率、CD8+ 细胞水平,差异无统计学意义。 相似文献
2.
Penedo Frank J.; Dahn Jason R.; Gonzalez Jeffrey S.; Molton Ivan; Carver Charles S.; Antoni Michael H.; Roos Bernard A.; Schneiderman Neil 《Canadian Metallurgical Quarterly》2003,22(2):220
This study evaluated relations among optimism, perceived stress management skills (PSMS), and positive mood in 46 men who had surgical treatment for localized prostate cancer. The authors found that optimism, PSMS, and positive mood scores were positively correlated. Positive mood was unrelated to demographic and disease-related control variables. In a hierarchical regression model controlling for PSMS, the relationship between optimism and positive mood became nonsignificant, whereas PSMS remained a correlate of positive mood. Results suggest that the relationship between optimism and positive mood may be mediated by belief in being able to use stress management techniques effectively. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
3.
Javier Roca-Pardiñas Carmen Cadarso-Suárez María J. Lado 《Computational statistics & data analysis》2008,52(4):1958-1970
In many applications, the joint effect of two continuous covariates on the target binary response may vary across groups defined by levels of a given factor. A testing procedure that would enable this type of surface-by-factor interactions to be detected has been designed. To accomplish this goal, a logistic generalized additive model (GAM) with bivariate continuous interactions varying across groups defined by levels of a factor is considered. A local scoring algorithm based on local linear kernel smoothers was implemented to estimate the proposed logistic GAM. Bootstrap resampling techniques were used for the purpose of testing for factor-by-surface interactions. Given the high computational cost involved, binning techniques were used to speed up computation in the estimation and testing processes. The adequacy of the bootstrap-based test was assessed by means of a simulation study. If a factor-by-surface interaction is detected in the model, it is then established that the use of the odds-ratio curves is very useful in obtaining a direct interpretation of the fitted model. The benefits of using this methodology when analyzing real data are illustrated by applying the technique to the outputs produced by a computerized system dedicated to the early detection of breast cancer. 相似文献
4.
乳腺癌中着丝粒蛋白CenpG的差异表达 总被引:4,自引:0,他引:4
用间接免疫荧光(IIF)验证了着丝粒蛋白CenpG的一种抗血清;通过对31例乳腺癌组织块及每一例病人的癌旁正常(非癌性)组织块蛋白提取物进行免疫印迹(Western blot)分析,发现多数情况下(71%)癌组织中着丝粒蛋白CenpG(95kD)过表达;在两例乳腺癌组织中还发现了一种能被CenpG抗血清识别的43kD蛋白质成分。结果表明,新近发现和命名的CenpG(或者还有其他相关成分)的差异表达可能与细胞恶性增殖有关。 相似文献
5.
激光远距作用的机制与效应 总被引:1,自引:0,他引:1
本文定量分析激光远距作用的机理并对它们在治癌中的作用作简要的论述。 相似文献
6.
Wide variability exists with respect to how breast cancer survivors respond to common psychological and psychosocial challenges of their disease, ranging from posttraumatic stress disorder to posttraumatic growth. This cross-sectional study examined contextual, disease-related, and intraindividual predictors of posttraumatic growth in 224 randomly selected breast cancer survivors. A series of hierarchical regression analyses found that age at diagnosis, marital status, employment, education, perceived intensity of disease, and active coping accounted for 34%, 35%, and 28% of the variance in growth in relationships with others, new possibilities, and appreciation for life. These findings suggest that a more comprehensive model of growth will be helpful in understanding the various factors that play a role in breast cancer survivors' perception of psychological and psychosocial growth. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
7.
8.
Conventional cancer therapies, the second leading cause of death worldwide, result in serious side effects and, at best, merely extend the patient''s lifespan by a few years. Searching for effective prevention is of high priority in both basic and clinical sciences. In recent decades natural products have been considered to be an important source of cancer chemopreventive agents. Red wine polyphenols, which consisted of various powerful antioxidants such as flavonoids and stilbenes, have been implicated in cancer prevention and that promote human health without recognizable side effects. Since resveratrol, a major component of red wine polyphenols, has been studied and reviewed extensively for its chemopreventive activity to interfere with the multi-stage carcinogenesis, this review focuses on recent progress in studies on cancer chemopreventive activities of red wine polyphenol extracts and fractions as well as other red wine polyphenols, like procyanidin B5 analogues and myricetin. 相似文献
9.
Yu. I. Petunin E. A. Djomina D. A. Klyushin M. Yu. Savkina 《Cybernetics and Systems Analysis》2006,42(3):449-455
Spline regression is used to analyze the influence of radiation on the cancer probability in a group of participants of Chernobyl
accident mitigation, depending on the exposure dose. A new method is proposed to approximate modified polygons by linear splines
with two nodes. An algorithm for the identification of a transition point is outlined.
__________
Translated from Kibernetika i Sistemnyi Analiz, No. 3, pp. 168–176, May–June 2006. 相似文献
10.
Reports an error in "Recovery of spatial alternation deficits following selective hippocampal destruction with kainic acid" by J. Patrick Kesslak and Fred H. Gage (Behavioral Neuroscience, 1986[Apr], Vol 100[2], 280-283). In the aforementioned article, the degrees of freedom reported in the Results section are incorrect. In the sixth paragraph on page 281, the second sentence should read as follows: Results of the ANOVA indicated a significant effect for surgical treatments. F(2, 25)=25.44, p1986-21445-001.) Examined whether the sympathetic ingrowth of superior cervical ganglion (SCG) fibers sprouting into the hippocampus following kainic acid (KA) lesion of CA3 and CA4 pyramidal cells in male Sprague-Dawley rats would contribute to behavioral recovery. 31 Ss were trained on a forced-choice task. After reaching criterion performance levels, Ss received either KA (8 nM/0.4 μl) or saline injections into the hippocampus and were again tested on the forced-choice task. Half of the Ss had their SCG removed 35 days after injections, and all were again tested on the forced-choice task. Analysis of variance (ANOVA) showed Ss receiving KA took significantly longer to reach criterion following injections. Removal of the SCG after recovery reintroduced the performance deficit of KA-treated Ss on the alternation task; no other group showed any effect for SCG removal. Results indicate that the SCG may have a modulatory effect in behavioral recovery, although other mechanisms may also be operating. (22 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献