The cover image is based on the Research Article V2O5/RGO/Pt nanocomposite on oxytetracycline degradation and pharmaceutical effluent detoxification by Mohan, H et al., DOI: 10.1002/jctb.6238 .
Herbivorous insects have the capacity to develop behavioral, physiological, and biochemical resistance mechanisms in response to chemical selection pressures. Among natural insect-plant associations, there are several cases of target-site insensitivity to and enhanced metabolism of plant allelochemicals. There are also known instances of physiological defenses such as extra rapid excretion or storage of toxic compounds. Multiple defenses seem to be prevalent in natural insect-plant interactions that involve toxic compounds, possibly reflecting the long time these interactions have had to evolve compared to insect-synthetic insecticide interactions. Synthetic insecticides were introduced about 45 years ago. Until recently they have been used as single-active-component preparations. As such, they have been and are very effective in producing insect populations with enhanced detoxification ability and target-site insensitivity. Most insecticide-resistant insect populations have one major defense mechanism. This feature makes the synthetic insecticides very useful tools for studies of insect defenses against toxic chemicals. Information gained from studies with insecticides can shed light on the capabilities of insects to adapt to toxicants in their environment. In assessing the validity of work with synthetic insecticides for natural systems, the fundamental differences between these substances and allelochemicals, and in their presentation to the insects, must, however, be considered. The prevalence of multiple defenses and reliance on modified physiological processes in natural interactions may reflect different properties of the natural chemicals in being generally highly biodegradable and often less acutely toxic than synthetic insecticides. In many cases, the plant allelochemicals are presented to the insects as mixtures. It is, however, to be expected that pest insects will evolve effective multiple defenses against synthetic insecticides. About 20% of all resistant populations have already developed multiple defenses, in most cases combinations of enhanced metabolism and target-site insensitivity. This implies that current crop protection practices need to be modified to ensure the continued usefulness of synthetic insecticides. To achieve this, it is important to study intensively not only insect-insecticide interactions but also the interactions operating in natural insect-plant associations. 相似文献
The effect of protein and birch bark powder (BBP) content of forage on detoxification capacity of root voles (Microtus oeconomus) was studied. Young voles were fed with eight different diets for two weeks. Individuals on low (3%) protein diets had significantly lighter livers and kidneys than those on moderate (6%) or high (12%) protein diets. Birch bark powder addition did not have significant effect on organ weight. Detoxification was significantly induced, apparently due to secondary compounds in BBP. The activity of ethoxyresorufin-O-dealkylase (EROD) was high when protein content or BBP concentration in forage was high as compared to low protein diets or diets containing no BBP. Glucuronidation, on the other hand, was not induced by BBP. High BBP content caused serious physiological stress to the voles. The only individuals surviving were those capable of sufficiently allocating energy and protein to detoxification. 相似文献
Epoxide hydrolase catalyzes a simple hydrolysis of reactive cyclic ethers that may otherwise alkylate and impair critical proteins and nucleic acids required for life. Although much less studied than the cytochrome P-450 monooxygenases that produce epoxides, differences in subcellular, tissue, pH, substrate, and inhibitor specificities argue for at least three forms of insect epoxide hydrolase. Increasing numbers of epoxides are being identified as plant allelochemicals, antifeedants, and essential hormones or precursors for herbivorous arthropods, and in many cases an associated alkene to diol pathway of metabolism is found. A role for epoxide hydrolase in arthropod-plant interactions is strongly supported by species comparisons and by age-activity and induction studies. Two major limitations for study in biochemical ecology of epoxide hydrolase are the lack of an effective in vivo inhibitor and a range of commercially available radiolabeled substrates for the enzymes. 相似文献
Five species of diabroticites with different host-plant preferences produced an essentially identical array of metabolites when fed radiolabeled cucurbitacin B synthesized in vivo and purified fromCucurbita maxima Duchesne seedlings. All species excreted the bulk of the cucurbitacin (67,17-94.59% total dpm), permanently sequestered a small proportion of a cucurbitacin conjugate in the hemolymph (0.98–2.76%), and apportioned the remainder between the gut, the body, and the eggs (when present). Markedly different ratios between the excretory metabolites (i.e., polar vs. unmetabolized cuc) suggest thatDibrotica virgifera virgifera, a grass specialist, andAcalymma vittatum, a cucurbit specialist, have lower rates of metabolic alteration than the polyphagousD. undecimpunctata howardi, D. balteata, andD. cristata, which is associated with relict prairies. Mean life-spans ofD. balteata and D. v. virgifera and maleA. vittatum decreased significantly with continuous feeding onCucurbita fruit containing cucurbitacins (vs. fruit devoid of cucs). The longevity of femaleA. vittatum, however, was unaffected by the presence of cucurbitacins. 相似文献