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1.
Patricia Seoane-Collazo Amparo Romero-Pic Eva Rial-Pensado Laura Liares-Pose nxela Estvez-Salguero Johan Fern Rubn Nogueiras Carlos Diguez Miguel Lpez 《International journal of molecular sciences》2021,22(4)
Several studies have reported that nicotine, the main bioactive component of tobacco, exerts a marked negative energy balance. Apart from its anorectic action, nicotine also modulates energy expenditure, by regulating brown adipose tissue (BAT) thermogenesis and white adipose tissue (WAT) browning. These effects are mainly controlled at the central level by modulation of hypothalamic neuropeptide systems and energy sensors, such as AMP-activated protein kinase (AMPK). In this study, we aimed to investigate the kappa opioid receptor (κOR)/dynorphin signaling in the modulation of nicotine’s effects on energy balance. We found that body weight loss after nicotine treatment is associated with a down-regulation of the κOR endogenous ligand dynorphin precursor and with a marked reduction in κOR signaling and the p70 S6 kinase/ribosomal protein S6 (S6K/rpS6) pathway in the lateral hypothalamic area (LHA). The inhibition of these pathways by nicotine was completely blunted in κOR deficient mice, after central pharmacological blockade of κOR, and in rodents where κOR was genetically knocked down specifically in the LHA. Moreover, κOR-mediated nicotine effects on body weight do not depend on orexin. These data unravel a new central regulatory pathway modulating nicotine’s effects on energy balance. 相似文献
2.
大位移井钻柱振动规律研究与应用 总被引:5,自引:0,他引:5
在大位移井钻井工程中钻柱受着各种振动,当各种振动共振时,钻柱承受着非常大的动载,很容易受损,同时,钻柱的振动影响着井壁的稳定,严重威胁着井下的作业安全。以大位移井近井底的钻柱为研究对象,分析了钻柱振动行为所遵循的规律。采用线性分析法,获得了大位移井钻柱横向振动和扭转振动的频谱方程。同时获得了钻柱各种共振频率的分布。经分析表明:大位移井钻柱的横向振动和扭转振动的共振频率与实际钻井转速非常接近,应合理选择转速以减小钻柱共振的发生。文章的分析研究为大位移井钻柱动态行为的研究提供了理论依据。 相似文献
3.
为安全、快速、有效地解决顶部极度弯曲、径向变形尺寸很大的落井抽油杆打捞难题,研制了一种在套管内打捞弯曲抽油杆的工具。该工具把以往从落物顶端引入打捞改为从落物侧面引入打捞,使复杂的井下故障处理简单化,从而缩短修井周期,减少修井费用,及时恢复油井生产。该项技术先后在江苏油田6口油井上应用,成功率100%,验证了工具的独特性和可靠性。 相似文献
4.
底部两层框架-抗震墙砖房抗震能力的分析方法与设计控制 总被引:5,自引:1,他引:4
提出了底部两层框架 -抗震墙砖房框剪层和砖混层的极限受剪承载力、侧移刚度、极限剪力系数计算公式 ,并基于设置不同数量抗震墙的底部两层框架 -抗震墙砖房的实例计算和弹塑性时程分析 ,给出了结构砖混过渡层与相邻框剪层的极限剪力系数比和侧移刚度比的合理取值及薄弱楼层位置判别和破坏状态评定的方法和原则。 相似文献
5.
针对铁路提速后出现的上承式简支钢板梁桥跨中横向振幅过大的问题,以羊楼司桥(L=32m单跨上承式简支钢板梁桥)为例进行实桥检测和数值模拟,建立车辆、线路、桥梁三者的联合模型,考虑轮轨接触力,应用MSC/DYTRAN大型结构分析程序进行车线桥动力相互作用的仿真分析。研究揭示我国用量最多的C62型货车以70∽80km/h的速度空载通过时,该跨度的钢板梁桥发生横向谐振的机理。此外,用该方法对32m跨长的组合梁结构进行桥梁动力特性及列车走行性分析,表明该结构满足提速货车和高速电动旅客列车走行的要求。研究结果对我国高速铁路桥梁建设和既有桥梁的改造具有积极意义。 相似文献
6.
Alia-Klein Nelly; Goldstein Rita Z.; Tomasi Dardo; Zhang Lei; Fagin-Jones Stephanie; Telang Frank; Wang Gene-Jack; Fowler Joanna S.; Volkow Nora D. 《Canadian Metallurgical Quarterly》2007,7(4):735
Reports an error in "What is in a word? No versus Yes differentially engage the lateral orbitofrontal cortex" by Nelly Alia-Klein, Rita Z. Goldstein, Dardo Tomasi, Lei Zhang, Stephanie Fagin-Jones, Frank Telang, Gene-Jack Wang, Joanna S. Fowler and Nora D. Volkow (Emotion, 2007[Aug], Vol 7[3], 649-659). The supplemental materials link should appear as follows: http://dx.doi.org/10.1037/1528-3542.7.3.649.supp. (The following abstract of the original article appeared in record 2007-11660-018.) The words "No" and "Yes" are involved in conditioning to prohibit or encourage behavior, respectively. The authors, therefore, hypothesized that these words would be attributed to endogenous valence, activating neuronal circuits involved with valence and emotional control. Functional MRI (fMRI) at 4 Tesla was used to record regional brain activity while participants were exposed to emphatic vocalizations of the words. Results showed that No and Yes were associated with opposite brain-behavior responses; while No was negatively valenced, produced slower response times, and evoked a negative signal in the right lateral orbitofrontal cortex (OFC), Yes was positively valenced, produced faster response times, and evoked a positive signal in a contiguous region of the OFC. Attribution of negative valence to No and trait anger control were associated with increased responsivity of the OFC to No. Inasmuch as sensitivity to the prohibitive command No develops during childhood through interaction with primary caregivers as the first social objects, our findings may implicate the lateral OFC in the neurobiology of emotion regulation and subsequent social development. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
7.
小高层建筑需通过剪力墙开洞(结构开洞)降低侧向刚度,本文对开洞部位以及墙肢和连梁设计提出一些看法,供设计人员参考。 相似文献
8.
New mesogenic homologous series having an azo central linkage was synthesized by fixing a rigid 4-methyl phenyl azo group
to resorcinol moiety. The terminal and lateral phenolic -OH groups were esterified, one by one, with 4-n-alkoxybenzoyl and acetyl group, respectively. All the twelve homologues synthesized exhibit mesomorphism. The methoxy ton-decyloxy andn-hexadecyloxy derivatives exhibit monotropic nematic mesophase whereas,n-dodecyloxy andn-tetradecyloxy derivatives exhibit enantiotropic nematic mesophase. The mesogenic properties of the present series was compared
with those of other structurally related mesogenic series.
Paper presented at the 5th National Seminar on Liquid Crystals, University of Jammu, Jammu, December 1997. 相似文献
9.
Ashraf Ayoub 《Computers & Structures》2003,81(7):411-421
This paper presents an inelastic element for the analysis of beams on foundations. The element is derived from a two-field mixed formulation with independent approximation of forces and displacements. The state determination algorithm for the implementation of the element in a general purpose nonlinear finite element analysis program is presented and its stability characteristics are discussed. Numerical studies are performed to compare the model with the classical displacement formulation. The studies confirm the superiority of the proposed model in describing the inelastic behavior of beams on foundations. 相似文献
10.