Identification and Pharmacokinetics of Multiple Potential Bioactive Constituents after Oral Administration of Radix Astragali on Cyclophosphamide-Induced Immunosuppression in Balb/c Mice

Radix Astragali (RA) is one of the commonly-used traditional Chinese medicines (TCMs) with an immunomodulatory effect confirmed in the clinic. In order to better understand the material basis for the therapeutic effects, this study was to investigate the absorbed components and their pharmacokinetic profile after oral administration of RA on cyclophosphamide-induced immunosuppression in Balb/c mice. As a result, 51 compounds in RA extract and 31 prototype compounds with nine metabolites were detected in mice plasma by the ultra-fast liquid chromatography (UFLC)-DAD-Q-TOF-MS/MS method. The pharmacokinetic parameters of five main constituents, including calycosin-7-O-glucoside, ononin, calycosin, formononetin and astragaloside IV, were obtained using HPLC-MS/MS. These results offered useful information for research on the pharmacological mechanism of RA and for its further development.     

用近红外光谱-PLS法非破坏性分析吡嗪酰胺片

应用偏最小二乘法结合近红外光谱法(NIRS-PLS)对吡嗪酰胺片中吡嗪酰胺的含量进行了非破坏性定量分析。采用近红外一阶导数800~1200 nm光谱区间建立了吡嗪酰胺片中吡嗪酰胺的含量定量分析模型,校正集预测值与真实值的相关系数(R)达到0.9989,预测均方根误差(RMSEP)为0.563,表明所建模型准确可靠,预测准确度高,NIRS-PLS方便快捷,可作为药品分析的一种常规方法。     

血清药物化学及其在功能性食品研发中应用展望

简要介绍了新兴学科血清药物化学的发展历程、学科理论基础、研究范畴及其实践研究概况,阐述了其在中药药效物质基础研究和新药开发中的积极意义,并展望了其在功能性食品研发、特别是在食品功能因子研发中的应用前景.