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以乙酸乙酯和草酸二乙酯为原料,经交叉Claisen酯缩合反应合成钠代草草酰乙酸乙酯。讨论反应时间、碱的浓度、原料配比对反应的影响。得出较佳工艺条件为:n(乙醇钠):n(乙酸乙酯):n(草酸二乙酯)=1.02:1.02:1.00,乙醇钠浓度为19.5%,反应时间为4h,产率为76%。用此盐与苯肼与酸性条件下进行加成缩合反应可制得1-苯基-3-羧酸乙酯-5-吡唑啉酮。产物的结构经红外光谱分析确认。 相似文献
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Tao Xiong Qiang Peng Yingchao Chen Mingle Li Jianjun Du Jiangli Fan Lingyun Jia Xiaojun Peng 《Advanced functional materials》2021,31(37):2103629
As a non-invasive treatment modality, photodynamic therapy has been a potential therapeutic method for metastatic and non-metastatic tumors. In order to further improve the tumor selectivity, phtotoimmunotherapy (PIT) has been developed recently, which includes antibodies as the active targeting ligands. However, traditional monoclonal antibody-based PIT suffers from long half-lives and extended phototoxic side-effects in vivo. Herein, a type I mechanism-based photoimmunoconjugate (PIC) is developed by incorporating anti-EGFR nanobody as the targeting ligand, and benzophenothiazine as the photosensitizer (PS). The small size and robust structure of the nanobody ensures excellent targeting accuracy and efficient renal excretion. Meanwhile, the type I PS is able to circularly transfer oxygen to superoxide radical upon irradiation to overcome hypoxia microenvironment. The PIC showed satisfying phototherapeutic ability both in normoxia and hypoxia, and displayed high selectivity towards tumor in vivo. By combining nanobody and Type I PS, the work presents a novel type of PIC for the precise treatment of tumors with high specificity and potency. 相似文献
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在无溶剂、无催化剂、微波辐射条件下,取代吲哚-3-甲醛与3-甲基-1-苯基-5-吡哇啉酮通过固相Knoevenagel缩合反应合成了一系列4-(取代吲哚基-3-次甲基)-3-甲基-1-苯基-5-吡唑啉酮,产物结构经IR,1H NMR确证.最佳反应条件为:n(吲哚-3-甲醛):n(3-甲基-1-苯基-5-吡哇啉酮)=1.... 相似文献
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A sandwich element can be isolated in all two-dimensional adhesive joints, thereby simplifying the analysis of strain and stress. An adhesive sandwich model has been developed that accommodates arbitrary loading, a bilinear adherend stress-strain response, and any form of nonlinear adhesive behavior. The model accounts for both the bending deformation and the shear deformation of the adherends. Stress and strain distributions in the adhesive were obtained by solving a system of six differential equations using a finite-difference method. For a sample adhesive sandwich, the adhesive strains and stresses from the new model were compared with those of other models. Finally, the model was coupled with an analytical solution for the detached section of an adhesive joint in peel. The stress and strain distributions in the adhesive and the root curvature of the peel adherend were then compared with finite element results. An accompanying article in this issue uses the model with experimental peel data to investigate the suitability of various adhesive failure criteria. 相似文献
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研究了 1,2 -双 ( 1′-苯基 - 3′-甲基 - 5′-氧代吡唑 - 4′-基 )乙二酮 -〔1,2〕( H2 A )与三正辛基氧化膦 ( TOPO )协同萃取 RE( ) ( RE=L a、Pr、Nd、Gd、Dy和 Y)的性能。通过考察萃取剂浓度、溶液酸度和温度对 RE( )萃取平衡的影响 ,确定了萃取机理和萃合物组成 ,求得了半萃取 p H1 /2 值和萃取反应平衡常数 Ks.e.。 相似文献
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以邻氨基苯酚对磺酸为原料,取代吡唑啉酮为偶合成分合成偶氮染料,并用Al、Fe金属盐络合生成生态金属络合染料。通过提纯并对其进行分析测定确定其结构,通过皮革染色的试验,分析了不同pH值条件下对生态染料染色性能的影响。 相似文献