论工法及企业开发工法的重要作用

介绍了工法的起源和发展、含义、分类及编写内容;叙述了工法的编写、开发、推广应用工作有利于企业的技术积累和管理标准化,论述了工法开发已成为施工企业特级资质准入的重要一环,以及工法开发在企业发展中带动企业科技进步、提升企业核心竞争力、提高企业经济效益、促进企业可持续发展的作用.     

Formulation of tablets containing an ‘in-process’ amorphized active pharmaceutical ingredient

The aim of this work was a preliminary study of the “in-process” amorphization of clopidogrel hydrogensulfate (CLP) as model drug during the production of tablets as dosage form. A solvent method was used for amorphization and the crystalline phase of CLP was detected by differential scanning calorimetry; the physical parameters of fresh and stored tablets were investigated. For the amorphous form, Aerosil 200 was selected as crystallization inhibitor as the most suitable of eight auxiliary agents. The optimum composition of the product for amorphization in the scaling-up process (100-fold) was 7 parts of CLP to 3 parts of Aerosil 200. In this scaled-up product, the amorphous CLP was fixed on the surface of microcrystalline cellulose. The tablet form further stabilized the amorphous form. Finally, the steps of an “in-process” amorphization are given as a protocol, which can promote stabilization of an amorphized active pharmaceutical ingredient.     

Food Safety Management System validation and verification in meat industry: Carcass sampling methods for microbiological hygiene criteria – A review

During validation and verification of the system for the proper implementation of HACCP principles, it is essential to rely on microbiological data. Considerable science research has been carried out during the last twenty years on sampling and testing of carcasses for hygiene criteria. This includes the preferable indicator microorganisms to be used, in order to indicate the general hygiene of slaughtering procedures, the evaluation of microbiological data gathered and the sampling methods. Furthermore, European Union (EU) and the United States have adopted the procedures for HACCP validation and verification in their legislation. The aim of this review is to demonstrate the relevant modern trends in this field of food science. In conclusion, microbiological data based on the indicators should be interpreted only to assess general trends in the hygiene process of the operator in order to take corrective action. Microbiological results, obtained only at the end of the slaughtering process, do not provide information on the cause of the problem. Therefore, ‘process-based’ microbiological criteria which are based on values measured at various stages of the process, including final carcass values, should be used. Finally, in order to implement an adequate monitoring system, non-destructive techniques of carcass sampling could be used instead of excision. The microbial recovery may be lower, but it is proportional to the excision recovery and therefore, non-destructive techniques, like swabbing with sponges, could be a practical sampling method for the estimation of indicators during the slaughtering procedure and hygiene evaluation.     

Atomic Afterimages

This article examines the recirculation of Robert Del Tredici's photographs of the Cold War nuclear weapons complex. Originally published in his groundbreaking book, At Work in the Fields of the Bomb (1987), a number of Del Tredici's photographs have been republished in a series of post‐Cold War US Department of Energy reports. The article examines the post‐Cold War circulation of Del Tredici's images in these official government reports and analyzes shifts in their meaning across different historical periods. Ultimately, this paper raises questions about the critical stance of Del Tredici's photographs as they are republished in government reports and examines ways in which the meaning of his photographs responds to both Cold War and post‐Cold War contexts.     

Growth of Escherichia coli,Salmonella enterica and Listeria spp., and their inactivation using ultraviolet energy and electrolyzed water,on ‘Rocha’ fresh-cut pears

The present study aimed at evaluating the growth of Escherichia coli, Salmonella enterica, and Listeria spp. and studying the efficacy of Ultraviolet-C (UV-C) irradiation, acidic electrolyzed (AEW) and neutral electrolyzed (NEW) waters in the reduction of these bacteria on ‘Rocha’ pear. Fresh-cut pieces were inoculated and incubated at 4–20 °C for 8 days. Inoculated pears were treated with UV-C (2.5–10 kJ/m²), AEW, NEW and sodium hypochlorite (SH) and microbiological and quality parameters were evaluated. The three bacteria, inoculated at 6.1–6.2 log cfu/g, grew on the pear at high growth rates at 12 and 20 °C reaching populations of 8.1–8.6 log cfu/g, in 24 h. At 8 °C the microorganisms increased their populations by at least 1 log cfu/g in three days. At 4 °C adaptation phases of less than 24 h for Listeria spp. were measured before exponential growth occurred and the enterobacteria did not grow despite having survived for 8 days. AEW and NEW caused microbial reductions similar to SH, of approximately 1 log cfu/g, while the best UV-C dose (7.5 kJ/m²) of at least 2.4 log cfu/g. Fresh-cut pears were a good substrate for foodborne bacteria emphasizing the importance of preventing contaminations and cross contaminations. The UV-C was more effective than the chemical decontaminations, as it provided superior microbial reductions without greatly affecting the quality of pears.     

一种应用于双向DC/DC变换器的新型耦合电感的设计

本文提出的"I王I"形耦合电感器通过增加磁路气隙的数量,使磁路的磁压分布更加均匀,与传统铁心电感器相比显著减小了磁路的电磁损耗、电磁干扰和线圈的涡流损耗,且增大了窗口面积。通过分析耦合电感器的磁通分布,建立磁路模型,给出了耦合电感器的设计方法,并对所提出的耦合电感器进行仿真,结合双向DC/DC变换器的实验验证了"I王I"形耦合电感器结构的可行性。     

Architecture Takes Time

Though condensed between the stages of design and completion, the conventional process of designing a building is time consuming, involving various stakeholders, planning processes and a wide team of consultants and contractors. What happens, though, if the time period of an architect's involvement is expanded? How might a more process-orientated approach shift the role of the architect? Tobias Armborst, Daniel D'Oca and Georgeen Theodore , principals of Interboro Partners in New York, describe how they have developed projects that have sought opportunities in expanding the timescale and remit of traditional practice.     

Built Conservation and the Unfinished Fabrics of Time

Differentiating between the static impulse to preserve and the more open-ended and imaginative process of conservation, Federica Goffi presents a building as ‘a fabric that, even when complete, is unfinished and open to change’. Associate Professor and Associate Director of Graduate Programs at the Azrieli School of Architecture and Urbanism at Carleton University in Ottawa, Goffi has written widely on the topic of time, particularly taking St Peter's in the Vatican by way of example.