Analytical model of displacement amplification and stiffness optimization for a class of flexure-based compliant mechanisms

The paper formulates an analytical method for displacement and stiffness calculations of planar compliant mechanisms with single-axis flexure hinges. The procedure is based on the strain energy and Castigliano’s displacement theorem and produces closed-form equations that incorporate the compliances characterizing any analytically-defined hinge, together with the other geometric and material properties of the compliant mechanism. Displacement amplification, input stiffness and output stiffness calculations can simply be performed for any serial compliant mechanism. The class of amplifying compliant mechanisms that contain symmetric corner-filleted or circular flexure hinges is specifically addressed here. A parametric study of the mechanism performance is performed, based on the mathematical model, and an optimization procedure is proposed, based on Lagrange’s multipliers and Kuhn-Tucker conditions, which identifies the design vector that maximizes the performance of these flexure-based compliant mechanisms. Independent finite element simulation confirms the analytical model predictions.     

Multi-enzyme layer-by-layer assembly for dual amplified ultrasensitive electronic detection of cancer biomarkers

The preparation and use of multi-enzyme layer-by-layer (LBL) assembled single wall carbon nanotube (SWCNT) composite labels for amplified ultrasensitive electrochemical detection of a cancer biomarker is described. The target protein, carcinoembryonic antigen (CEA), is sandwiched between an electrode surface-confined capture anti-CEA antibody and the secondary signal anti-CEA/enzyme-LBL/SWCNT bioconjugate. The dual biocatalytic signal amplification for CEA monitoring is achieved through both the numerous enzymes loaded on the CNTs and redox-recycling of the enzymatic products in the presence of the secondary enzyme and the corresponding substrate. Our novel dramatic signal amplification strategy, with a detection limit of 0.04 pg mL⁻¹, shows about 2-4 orders of magnitude improvement in sensitivity for CEA detection compared with other universal signal amplified assays, which makes our signal amplification approach hold great potential applications in detection of ultra-trace protein biomarkers.     

液压缸集成位移传感器信号调理电路设计

针对常见液压缸位移传感器在高集成、小体积环境的应用缺陷,开展了一种高集成液压缸位移传感器信号调理电路的设计研究。为获取高质量的位移检测信号,在分析了位移传感器原始信号特征的基础上,开展了直流隔离、放大、电源转换以及滤波电路等信号调理电路的研究。电路的有效性通过Multisim和Proteus进行仿真及实验验证,仿真及实验结果表明,该信号调理电路可将位移传感器原始信号转变为标准的简谐信号,便于信号的后续采样细分,为提高液压缸位移的检测精度提供了支撑。     

用作EDFA光泵浦的激光二极管

近几年来,用作掺铒光纤放大器(EDFA)泵浦光源的半导体激光器,获得了积极的开发和使用。1.48μm 波长大功率激光二极管已商品化,并向更高水平发展。0.98μm 的应变量子阱结构器件也处在开发中,已有部分试用样品。文中介绍1.48μm 和0.98μm 波长大功率半导体激光器的主要结构和开发现状。     

Seismic microzonation of the historic peninsula of İstanbul

In this study, the geological and geotechnical conditions of old Istanbul (Fatih and Eminönü provinces) were investigated in detail and a seismic microzonation study was undertaken for this historical peninsula, which is the site of many ancient structures. Dynamic site response, liquefaction potential and slope stability analyses were carried out, based on field and laboratory tests and earthquake time histories computed with respect to probabilities of exceedance of 10 and 40% in 50 years. The output data obtained from the analyses were evaluated by GIS techniques, and ground shaking, liquefaction susceptibility and landslide hazard maps were prepared.     

超声变幅杆的动力学分析

超声变幅杆是功率超声振动系统的重要组成部分,它的主要功能是把机械振动位移放大并把能量集中在较小的辐射面上,变幅杆的放大系数是超声振动系统中的重要参数。用微元法建立圆锥形超声变幅杆纵向振动的波动方程,用分离变量法和连续振动体的边界条件求解超越波动方程,得到圆锥形超声变幅杆放大系数与变幅杆的大小端直径之比、长度以及外激频率3个变量之间的数学表达式。为研究变幅杆的放大系数与变幅杆的大小端直径之比、长度以及外激频率的关系,依次把3个变量中的2个变量设为常量,对另外一个变量进行抽样,计算变幅杆的放大系数。通过Matlab对超声变幅杆放大系数的样本计算数据进行曲线拟合,定性分析了圆锥形超声变幅杆放大系数随变幅杆大小端直径之比、长度、外激振动频率变化的关系。     

悬浮Vero细胞快速扩增轮状病毒

目的探讨在悬浮Vero细胞中快速扩增轮状病毒(RV)的方法。方法 Vero细胞经消化后,直接接种KMG1b7株RV。采用微量滴定法、PAGE和RT-PCR等方法比较悬浮扩增、静置培养及微载体发酵培养RV的感染性滴度、基因组核酸带型和型特异VP7基因序列;采用电镜观察和Westernblot鉴定悬浮扩增RV的形态及结构蛋白的抗原性。结果悬浮细胞扩增的RV接种24h后病毒感染性滴度达峰值,为6.00lgCCID50/ml;而静置培养和微载体发酵培养分别在接种后(96±24)h和(48±6)h达峰值,分别为(6.00±0.25)lgCCID50/ml和(6.50±0.25)lgCCID50/ml。悬浮扩增的RV基因组呈典型的4-2-3-2G1血清型带型,G1型特异基因VP7序列未发生突变。悬浮扩增的RV形态和结构蛋白的抗原性未发生改变。结论在悬浮Vero细胞中扩增RV可以缩短病毒制备周期,提高病毒收获量,有利于RV疫苗的研制或生产。     

爆破地震作用下地基的动力响应分析

通过简化爆破荷载的形式,对爆破振动作用下地基位移方程进行了推导,在此基础上给出了爆破作用下影响地基位移的诸要素,并提出了地基位移幅值在爆破作用下的变化规律,这对结构抗震工作的开展有着重要意义。     

Effect of Vehicle Velocity on the Dynamic Amplification of a Vehicle Crossing a Simply Supported Bridge

Many writers, using both experimental tests and complex numerical models, have examined the effect of vehicle velocity on a highway bridge’s dynamic amplification. Although these tests and models give valuable quantitative information on dynamic amplification, they give little insight into how amplification is affected by individual vehicle/bridge parameters. This paper uses relatively simple numerical models to investigate the effect of vehicle velocity on a bridge’s dynamic amplification. A single vehicle crossing a simply supported bridge is modeled as a constant point force. A set of critical velocities are determined associated with peaks of dynamic amplification for all beams. The reasons for these large amplifications are discussed. A more complex finite element model, validated with field tests, is used to test the applicability of the conclusions obtained from the simple models to a realistic bridge/vehicle system.     

JFFT控制特性的近似解析分析

由高Ｔｃ超导材料制备的Ｊｏｓｅｐｈｓｏｎ磁通流晶体管（ＪＦＦＴ）的控制特性中呈现了很强的非对称性。笔者分析了ＪＦＦＴ的控制场分布，并在电流－相位线性近似条件下，获得了这种非对称控制特性的近似解析描述。解析分析结果揭示了由控制线产生的不均匀外磁场是控制特性中非对称性产生的原因。其解析分析与实验结果之间符合较好。文中还讨论了各结构参数对ＪＦＦＴ的最大电流放大倍数的影响。