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排序方式: 共有285条查询结果,搜索用时 15 毫秒
1.
Carmen de Jesús-Gil Lídia Sans-de San Nicols Ester Ruiz-Romeu Marta Ferran Laura Soria-Martínez Irene García-Jimnez Anca Chiriac Josep Manel Casanova-Seuma Josep Manel Fernndez-Armenteros Sherry Owens Antonio Celada Michael D. Howell Ramn María Pujol Luis Francisco Santamaria-Babí 《International journal of molecular sciences》2021,22(4)
Candida albicans (CA) infections have been associated with psoriasis onset or disease flares. However, the integrated immune response against this fungus is still poorly characterized in psoriasis. We studied specific immunoglobulins in plasma and the CA response in cocultures of circulating memory CD45RA− cutaneous lymphocyte antigen (CLA)+/− T cell with autologous epidermal cells from plaque and guttate psoriasis patients (cohort 1, n = 52), and also healthy individuals (n = 17). A complete proteomic profile was also evaluated in plaque psoriasis patients (cohort 2, n = 114) regarding their anti-CA IgA levels. Increased anti-CA IgA and IgG levels are present in the plasma from plaque but not guttate psoriasis compared to healthy controls. CA cellular response is confined to CLA+ T cells and is primarily Th17. The levels of anti-CA IgA are directly associated with CLA+ Th17 response in plaque psoriasis. Proteomic analysis revealed distinct profiles in psoriasis patients with high anti-CA IgA. C-C motif chemokine ligand 18, chitinase-3-like protein 1 and azurocidin were significantly elevated in the plasma from plaque psoriasis patients with high anti-CA levels and severe disease. Our results indicate a mechanism by which Candida albicans exposure can trigger a clinically relevant IL-17 response in psoriasis. Assessing anti-CA IgA levels may be useful in order to evaluate chronic psoriasis patients. 相似文献
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Josep Bassaganya‐Riera Jennifer King Raquel Hontecillas 《European Journal of Lipid Science and Technology》2004,106(12):856-861
The objective of this review is to highlight the use of pig models for investigating safety, efficacy and the mechanisms of action of conjugated linoleic acid (CLA). Although CLA elicits positive effects in animal models and in vitro systems, a consistent concern in terms of translational research is that the health benefits observed by using these model systems cannot be extrapolated directly into humans. Conversely, the similarities between pigs and humans make the pig an ideal model for examining the health benefits of dietary supplements, functional foods and nutraceuticals. We have developed pig models of viral and bacterial infection to examine the preventive role of dietary CLA supplementation on virally induced immunosuppression and gut health, respectively. Results from these studies indicate that CLA significantly enhances the immune function while limiting the catabolic effects of uncontrolled immune and inflammatory responses. The scientific findings in pig models and human clinical trials demonstrate that CLA modulates immune responses in pigs and humans. Pig models of immunomodulation represent significant improvements over other animal models and in vitro systems because they mimic more closely the compartmentalization of the human immune system and the clinical presentation of human infectious, immune and inflammatory diseases. 相似文献
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通过牛乳液中添加共轭亚油酸(CLA),分析杀菌温度、均质压力、乳化剂类型、CLA添加量对牛乳稳定性的影响.实验结果表明:脱脂乳中添加0.17%的CLA稳定性较好,口感纯正;当灭菌温度超过100℃时,CLA含量明显降低;以单苷酯、三聚苷酯和蔗糖酯的混合乳化剂,按1∶1∶2混合的乳液稳定性好;35MPa以上的均质压力下,乳液中的脂肪球细小,分布均匀,口感细腻。 相似文献
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The group of conjugated fatty acids known as conjugated linoleic acid (CLA) isomers have been extensively studied with regard to their bioactive potential in treating some of the most prominent human health malignancies. However, CLA isomers are not the only group of potentially bioactive conjugated fatty acids currently undergoing study. In this regard, isomers of conjugated α‐linolenic acid, conjugated nonadecadienoic acid and conjugated eicosapentaenoic acid, to name but a few, have undergone experimental assessment. These studies have indicated many of these conjugated fatty acid isomers commonly possess anti‐carcinogenic, anti‐adipogenic, anti‐inflammatory and immune modulating properties, a number of which will be discussed in this review. The mechanisms through which these bioactivities are mediated have not yet been fully elucidated. However, existing evidence indicates that these fatty acids may play a role in modulating the expression of several oncogenes, cell cycle regulators, and genes associated with energy metabolism. Despite such bioactive potential, interest in these conjugated fatty acids has remained low relative to the CLA isomers. This may be partly attributed to the relatively recent emergence of these fatty acids as bioactives, but also due to a lack of awareness regarding sources from which they can be produced. In this review, we will also highlight the common sources of these conjugated fatty acids, including plants, algae, microbes and chemosynthesis. 相似文献
6.
Portable Infrared Spectrometer to Characterize and Differentiate Between Organic and Conventional Bovine Butter
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![点击此处可从《Journal of the American Oil Chemists](/ch/ext_images/free.gif)
Marçal Plans Pujolras Huseyin Ayvaz Mei‐Ling Shotts Richard A. Pittman Jr Sarah Herringshaw Luis E. Rodriguez‐Saona 《Journal of the American Oil Chemists' Society》2015,92(2):175-184
The performance of a portable infrared system combined with pattern recognition to discriminate between organically and conventionally produced bovine butter samples as well as to predict the levels of conjugated linoleic acid (CLA) were evaluated. Sixty butter (27 organic and 33 conventional) samples were used in this study. Bovine butter–fat were applied onto an attenuated total reflectance infrared (ATR‐IR) accessory equipped with a five‐bounce ZnSe crystal set at 65 °C for spectral collection. In addition, ATR‐IR spectra of bovine butter were directly collected at room temperature to avoid phase separation. The fatty acid profile and the levels of CLA were determined using reference FAME‐GC‐FID analysis. SIMCA models showed well separated clusters that discriminated between organic and conventional bovine butters due to C=C trans bending out of the plane vibration modes band at 967 cm?1. Additionally, strong PLSR models were developed to predict CLA levels using butter–fat and bovine butter spectra with SEP of 0.05 % and RPD of 4.7, indicating that the models are suitable for quality control applications. Portable IR technology offers the ability for “in situ” analysis of butters that is much less time consuming than current analytical practices for authentication and quality control efforts by the industry. 相似文献
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尿素包合法纯化共轭亚油酸条件的优化研究 总被引:3,自引:0,他引:3
采用尿素包合法对纯度在70%的共轭亚油酸(CLA)进行了提纯研究。共轭亚油酸在甲醇与尿素形成的体系中70℃加热回流2h,其中的饱和脂肪酸和单不饱和脂肪酸与尿素形成复合物析出,从而可以使共轭亚油酸得到纯化。研究发现,尿素包合共轭亚油酸的最佳工艺条件为:共轭亚油酸,尿素/甲醇=1:2.5:8,包合温度为-15℃,包合时间为6h,得到的共轭亚油酸经过三氟化硼-甲醇溶液衍生化后,用气相色谱进行检测纯度可达93,6%,基本实现了共轭亚油酸的分离纯化。 相似文献
10.
Yubin Lan Qi Fang M. F. Kocher M. A. Hanna 《International Journal of Food Properties》2013,16(1):105-116
Thermal properties of native tapioca starch, including thermal conductivity, specific heat, and thermal diffusivity at 4, 15, and 30% moisture contents, and 25, 50, and 75°C temperature levels were studied. Thermal conductivity was measured using a line‐heat source thermal probe equipped with a computerized data acquisition system; specific heat was measured using Differential Scanning Calorimetry (DSC) and thermal diffusivity was calculated from the thermal conductivity, density, and specific heat. Thermal conductivity, specific heat, and thermal diffusivity increased with the increase of temperature and/or moisture content. Prediction models for the thermal properties of tapioca starch were developed for practical applications. 相似文献