Marine Phospholipids from Fishery By-Products Attenuate Atherosclerosis

In this study, the anti-atherosclerotic properties of three marine phospholipids (MPLs) extracts from fishery by-products including codfish roe, squid gonad, and shrimp head are verified. Their effects on key factors involved in atherosclerosis are examined and compared to explore whether the differences in their constitutions lead to the differences in the function. All three MPLs dampen oxidation of low- density lipoproteins (LDL) in vitro. Treating RAW264.7 macrophages and HUVECs endothelial cells with each MPLs ranging 10–100 µg mL⁻¹ does not decrease cell viability, yet ox-LDL caused cytotoxicity of both cells are alleviated by 50 or 100 µg mL⁻¹ MPLs treatment. In addition, the three MPLs reduce ox-LDL induced macrophage foam-like transition, mainly through inhibition of lipid uptake. Of the three MPLs, the one from squid gonad exhibits the best effect. On the other hand, all three MPLs modulate inflammatory responses, equally, by inhibiting the adhesion of monocytes to endothelial cells, and decreasing secretion of pro-inflammatory cytokines IL-6 and MCP-1. Using a high-cholesterol diet induced zebrafish model, it is found that all three MPLs, especially the one from squid gonad, alleviates cholesterol accumulation in early plaques, and decreases total cholesterol as well as lipid peroxide in vivo. Practical Applications: As a way of making the best of the increasingly scarce marine resources, valuable lipid components can be recovered from by-products and wastes from the fishery industry. Here, we tested the anti-atherosclerotic effects and the mechanisms of three MPLs extracted from codfish roe, squid gonad, and shrimp head. Our study provides further evidence that marine phospholipids extracted from fishery by-products could protect against atherosclerosis, and helps to elucidate the structure-function relationship of MPLs.     

"适可而止"--"集合设计"在浙大网新科技园上的设计策略

“适可而止”是一种态度。文章用这个词归纳并品评了“集合设计”在浙大网新科技园项目上的设计策略。实际上,这种态度不仅体现在本项目的操作上,也反映在大部分中国建筑师目前时常面临的选择当中——关键是态度的指向能否逐渐形成更多积极性的策略。文章希望在追求“单纯性”、设计实验、细节控制和如何介入城市空间等方面的讨论能引导更多的读者有意识地用批判的眼光反观和印证自己的设计实践。     

麻柳场嘉二3储层酸化工艺室内实验研究

储层酸化改造是低渗碳酸盐岩油气藏增产的主要措施之一。由于储层性质不同，改造方案的实施效果差异较大。对麻柳场嘉二^3储层酸化工艺室内实验研究和现场实践发现，胶束酸多级注入酸化-闭合酸化工艺对川南麻柳场嘉陵江组的储层改造行之有效。     

Investigation into polishing process of CVD diamond films

A new technique used for polishing chemical vapor deposition (CVD) diamond films has been investigated, by which rough polishing of the CVD diamond films can be achieved efficiently. A CVD diamond film is coated with a thin layer of electrically conductive material in advance, and then electro-discharge machining (EDM) is used to machine the coated surface. As a result, peaks on the surface of the diamond film are removed rapidly. During machining, graphitization of diamond enables the EDM process to continue. The single pulse discharge shows that the material of the coated layer evidently affects removal behavior of the CVD diamond films. Compared with the machining of ordinary metal materials, the process of EDM CVD diamond films possesses a quite different characteristic. The removal mechanism of the CVD diamond films is discussed.     

均匀设计法在烷基糖苷合成中的应用

在烷基糖苷的合成反应中，影响糖苷得率的因素很多，且各因素之间又存在着相互牵制作用。为了探索合成的最佳条件，我们采用了均匀实验设计法。实验证明：它特别适用于多因素多水平的实验设计，同时减少了实验的次数，降低了实验的费用，提高了工作效率。     

Clay compaction modelling by homogenization theory

The modelling of hydromechanical behavior of clayey sediments by homogenization theory is described. The rheological model of clays buried in depth requires a three-dimensional approach and laboratory experiments to quantify the model parameters. An iterative process which can be coupled to any homogenization method is used to model the porous media behavior. Hydromechanical compaction results from oedometric experiments are simulated with the proposed model.     

Experimental and simulation studies of gas sorption processes in polycarbonate films

This work reports the experimental isotherms describing the concentration of oxygen and nitrogen in poly(bisphenol A carbonate-co-4,4′-(3,3,5-trimethylcyclohexylidene) diphenol carbonate) vs pressure, at 30 °C. The solubility coefficients are interpreted in terms of the Flory-Huggins theory, obtaining reasonable values for the enthalpic polymer-gas parameter. A new method is outlined to simulate the probabilities of inserting/removing a gas molecule in a host matrix already containing n molecules of gas. The simulated isotherms representing the pressure dependence of the concentration exhibit the same pattern as those experimentally obtained.