IL-27与LTB4在非小细胞肺癌中的表达及意义

目的:探讨IL-27与LTB4在非小细胞肺癌组织中的表达情况及临床意义。方法:采用免疫组化S-P法分别检测60例非小细胞肺癌组织及正常肺组织中的IL-27与LTB4的表达水平。结果:IL-27与LTB4在肺癌组织中的总阳性表达率分别为41.67%、63.33%,各种检测指标的阳性率在肺癌组织与对照组之间均存在着差异性(P<0.05)。IL-27与LTB4的表达均与肿瘤的分化程度有关(P<0.05),IL-27的表达与肺癌的TNM分期相关(P<0.05),与病理类型无关(P>0.05)。LTB4的表达与组织学类型、临床分期无关(P>0.05),IL-27与LTB4之间存在密切相关性。结论:IL-27、LTB4与肺癌发生机制及发展有密切关系,联合进行检测两者表达水平对于肺癌临床诊断、评估恶性程度及判断预后有重要意义。     

半固态ZnAl 27合金及其二次加热组织

研究了半固态ZnAl27合金及其二次加热组织。结果表明，半固态ZnAl27合金基本无宏观偏析，其组织为细小均匀的近球形非枝晶，综合力学性能远远高于常规铸造合金；二次加热后，α相进一步球化，边缘变得光滑圆整，可以满足半固态触变成形的需要。     

A new way for constructing high accuracy shock-capturing generalized compact difference schemes

The generalized compact (GC) schemes and some of their important properties are presented. And a new way for constructing high order accuracy and high-resolution GC schemes is presented. The schemes constructed by using this way could satisfy some principles and demands prescribed in advance to ensure some desired properties to the schemes, such as the principle about suppression of the oscillations, the principle of stability, the order of accuracy and number of scheme points, etc. As two examples, a three-point third-order compact scheme and a three-point fifth-order GC scheme satisfying the principle about suppression of the oscillations and the principle of stability are described in this paper. Numerical results show that these schemes are shock-capturing. The time-dependent boundary conditions proposed by Thompson are well employed when the algorithm is applied to the Euler equations of gas dynamics. Fourier analysis shows that the resolution characteristics are spectral-like.     

内置汉字字模的EPROM制作技术

本文介绍了一种将汉字点阵字模固化于EPROM的技术。作为一种标准接口模块，可以应用在例如点阵式液晶显示器LCD等场合。     

改进渣浆泵过流件铸造工艺及硬度的措施

介绍了渣浆泵过流件材质的化学成分及其正交试验的优选过程，以及重新制定的铸造工艺。     

稀土对ZA27合金阻尼性能的影响

研究了稀土对ZA27合金阻尼性能的影响规律。结果表明：稀土变质可提高ZA27合金的阻尼性能，经稀土变质后的试样，其内耗是未变质的试样的1．4倍。ZA27合金为发挥其阻尼作用，在频率高于70Hz时，效果明显，且经稀土变质后的试样强迫振动衰减效果比未变质的试样强。     

Mutant p53 Mediates Sensitivity to Cancer Treatment Agents in Oesophageal Adenocarcinoma Associated with MicroRNA and SLC7A11 Expression

TP53 gene mutations occur in 70% of oesophageal adenocarcinomas (OACs). Given the central role of p53 in controlling cellular response to therapy we investigated the role of mutant (mut-) p53 and SLC7A11 in a CRISPR-mediated JH-EsoAd1 TP53 knockout model. Response to 2 Gy irradiation, cisplatin, 5-FU, 4-hydroxytamoxifen, and endoxifen was assessed, followed by a TaqMan OpenArray qPCR screening for differences in miRNA expression. Knockout of mut-p53 resulted in increased chemo- and radioresistance (2 Gy survival fraction: 38% vs. 56%, p < 0.0001) and in altered miRNA expression levels. Target mRNA pathways analyses indicated several potential mechanisms of treatment resistance. SLC7A11 knockdown restored radiosensitivity (2 Gy SF: 46% vs. 73%; p = 0.0239), possibly via enhanced sensitivity to oxidative stress. Pathway analysis of the mRNA targets of differentially expressed miRNAs indicated potential involvement in several pathways associated with apoptosis, ribosomes, and p53 signaling pathways. The data suggest that mut-p53 in JH-EsoAd1, despite being classified as non-functional, has some function related to radio- and chemoresistance. The results also highlight the important role of SLC7A11 in cancer metabolism and redox balance and the influence of p53 on these processes. Inhibition of the SLC7A11-glutathione axis may represent a promising approach to overcome resistance associated with mut-p53.     

钢丸增强ZA27复合材料的制备与摩擦磨损特性

采用搅溶加压铸造研制了钢丸增强ＺＡ２７复合材料（ＺＳＣ），复合工艺简便，ＺＳＣ组织致密，钢丸与基体呈冶金结合，切削加工性能良好；在干摩擦和油润条件下，ＺＳＣ的耐磨性随钢丸量的增加而增加，并优于相同试验条件下的ＺＡ２７合金；干摩擦下ＺＳＣ具有自润滑能力和良好的耐磨减摩性能，油润下随滑动速度和载荷的增大其耐磨性较ＺＡ２７更具优势。     

Protein design to understand peptide ligand recognition by tetratricopeptide repeat proteins

Protein design aims to understand the fundamentals of protein structure by creating novel proteins with pre-specified folds. An equally important goal is to understand protein function by creating novel proteins with pre-specified activities. Here we describe the design and characterization of a tetratricopeptide (TPR) protein, which binds to the C-terminal peptide of the eukaryotic chaperone Hsp90. The design emphasizes the importance of both direct, short-range protein-peptide interactions and of long-range electrostatic optimization. We demonstrate that the designed protein binds specifically to the desired peptide and discriminates between it and the similar C-terminal peptide of Hsp70.     

挤压铸造ZA27合金的凝固特性及组织分析

研究了ZA27合金挤压铸造的凝固特性和组织.差热分析表明挤压铸造可以使锌铝合金的凝固过程发生变化,压力在750MPa以上可抑制共晶反应的发生.压力下凝固,可大大减少ZA27合金的缩孔、缩松、气孔等缺陷,提高合金致密度,细化和改善组织,减轻枝晶偏析,使铸件整体的成分均匀.