Concentration of Antifouling Biocides and Metals in Sediment Core Samples in the Northern Part of Hiroshima Bay

Accumulation of Ot alternative antifoulants in sediment is the focus of this research. Much research had been done on surface sediment, but in this report, the accumulation in the sediment core was studied. The Ot alternative antifoulants, Diuron, Sea-Nine211, and Irgarol 1051, and the latter’s degradation product, M1, were investigated in five samples from the northern part of Hiroshima Bay. Ot compounds (tributyltin (TBT) and triphenyltin (TPT)) were also investigated for comparison. In addition, metal (Pb, Cu, Zn, Fe and Mn) levels and chronology were measured to better understand what happens after accumulation on the sea floor. It was discovered that Ot alternative antifoulant accumulation characteristics in sediment were like Ot compounds, with the concentration in the sediment core being much higher than surface sediment. The concentration in sediment seems to have been affected by the regulation of Ot compounds in 1990, due to the concentration of Ot alternative antifoulants and Ot compounds at the survey point in front of the dock, showing an increase from almost the same layer after the regulation.     

单片机控制的简易单相逆变电源

文章介绍了用AT89C1051单片机控制的单相逆变器电源的设计方案,该方案通过消谐PWM控制可使逆变电源的输出谐波明显减少,并经小容量的高通滤波后即可得到高质量的正弦波电压输出。该电源通过单相电机的运行试验证明,效果良好,而且结构简单、成本低廉、性能稳定可靠,具有一定的实用价值。     

川西致密气藏裸眼水平井分段压裂技术

川西中浅层气藏致密、低孔、低丰度,裸眼水平井分段压裂是开发该类气藏的有效技术之一,但存在压裂参数难确定、压裂管柱下入难度大、水平段钻井液替出困难、压裂液返排效率低等问题。为此,在分析气藏特点和借鉴多级压裂经验的基础上,提出将裸眼水平段分成8~10段进行压裂,砂比优化为17%~21%;在注入前置液阶段采用支撑剂段塞处理近井效应,降低初期施工压力及形成多裂缝的概率;设计了可完全替出水平段钻井液的压裂管柱;制定循环钻井液、旋转管柱和给管柱加压的措施,保证压裂管柱下至设计位置;采用液氮伴注和大小油嘴交替更换的助排和返排技术,提高压裂液返排的速度和效率。XP105-1H井的裸眼水平段分成8段,采用以上技术和措施成功分段压裂;压后自然返排,返排率达95%;压后天然气产量6.441 2×104 m3/d,是相同层位水平井的2倍,天然气无阻流量达到23.168×104 m3/d。XP105-1H井裸眼水平段分段压裂的成功,可为类似致密气藏裸眼水平井分段压裂提供有益参考。      

精密双稳压控制器ADM1051/1051A

ADM1051／1051A是模拟器件公司（Analog Devices）生产的精密双稳压控制器，它具有1．515V和1．818V两种输出电压。主要用于个人电脑主板上的总线终端及接口的供电。本文介绍了该芯片的工作原理和引脚功能，最后给出了其简单的应用电路及连接注意事项。     

A Combined DNA-Affinic Molecule and N-Mustard Alkylating Agent Has an Anti-Cancer Effect and Induces Autophagy in Oral Cancer Cells

Although surgery or the combination of chemotherapy and radiation are reported to improve the quality of life and reduce symptoms in patients with oral cancer, the prognosis of oral cancer remains generally poor. DNA alkylating agents, such as N-mustard, play an important role in cancer drug development. BO-1051 is a new 9-anilinoacridine N-mustard-derivative anti-cancer drug that can effectively target a variety of cancer cell lines and inhibit tumorigenesis in vivo. However, the underlying mechanism of BO-1051-mediated tumor suppression remains undetermined. In the present study, BO-1051 suppressed cell viability with a low IC(50) in oral cancer cells, but not in normal gingival fibroblasts. Cell cycle analysis revealed that the tumor suppression by BO-1051 was accompanied by cell cycle arrest and downregulation of stemness genes. The enhanced conversion of LC3-I to LC3-II and the formation of acidic vesicular organelles indicated that BO-1501 induced autophagy. The expression of checkpoint kinases was upregulated as demonstrated with Western blot analysis, showing that BO-1051 could induce DNA damage and participate in DNA repair mechanisms. Furthermore, BO-1051 treatment alone exhibited a moderate tumor suppressive effect against xenograft tumor growth in immunocompromised mice. Importantly, the combination of BO-1051 and radiation led to a potent inhibition on xenograft tumorigenesis. Collectively, our findings demonstrated that BO-1051 exhibited a cytotoxic effect via cell cycle arrest and the induction of autophagy. Thus, the combination of BO-1051 and radiotherapy may be a feasible therapeutic strategy against oral cancer in the future.