Analysis of nuclear proliferation resistance

All the civil nuclear energy systems could contribute to the proliferation risk that weapons-usable material might be diverted or misused for the weapons purpose by terrorists or states. Proliferation-resistant nuclear energy systems are of great importance for the peaceful use of nuclear energy by impeding the diversion or undeclared production of weapons-usable material by states. Since the National Alternative Systems Assessment Program (NASAP) carried out the assessment of proliferation resistance of the civil nuclear energy systems in late 1970s, several comprehensive studies have been performed, including the International Nuclear Fuel Cycle Evaluation (INFCE) by the International Atomic Energy Agency (IAEA), the Spent Fuel Standard by the United States National Academy of Science, the Technical Opportunities for Increasing the Proliferation Resistance of Global Civilian Nuclear Power Systems (TOPS) by the United States Department of Energy, the International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO) Methodology by the IAEA, and the Generation IV Nuclear Energy Systems (Gen IV) by the Gen IV International Forum. However, all these studies appear lack in the interpretation of country-specific proliferation risk that is arbitrary imposed to the specific countries by major nuclear weapons states, even though the countries are members of the Treaty on the Non-Proliferation of Nuclear Weapons (NPT). This paper outlines the assessments of proliferation resistance of the above studies, points out the country-specific proliferation risk, and suggests further studies to increase the proliferation resistance of the civil nuclear energy systems in the specific NPT member countries such as South Korea.     

塞来昔布对鼻咽癌细胞株HNE-1增殖与侵袭能力、VEGF表达及放疗敏感性的影响

目的探讨环氧化酶-2(COX-2)选择性抑制剂塞来昔布(Celecoxib)对鼻咽癌细胞株HNE-1增殖与侵袭能力、血管内皮生长因子(VEGF)表达及放疗敏感性的影响。方法HNE-1细胞经不同浓度塞来昔布处理后,采用MTT法检测各组细胞的增殖水平,细胞侵袭试验检测细胞的侵袭转移能力,RT-PCR及ELISA分别检测细胞VEGF mRNA的转录水平及蛋白的表达水平,克隆形成试验检测细胞对放疗的敏感性。结果不同浓度的塞来昔布均可显著抑制HNE-1细胞的增殖与侵袭能力,并显著下调HNE-1细胞VEGF在mRNA及蛋白水平的表达,且均呈剂量依赖性,差异具有统计学意义。克隆形成试验结果表明,125μmol/L的塞来昔布与放疗联用对HNE-1细胞有明显的协同抗肿瘤效应。结论塞来昔布对HNE-1细胞的增殖与侵袭能力及VEGF的表达均有明显的抑制作用;经塞来昔布处理可增强HNE-1细胞对放疗的敏感性。     

6Ckine修饰的树突状细胞促进T淋巴细胞增殖和分化的作用

目的研究次级淋巴组织趋化因子(6Ckine)修饰的树突状细胞(DC)对T淋巴细胞增殖和分化的影响。方法用携带人6Ckine基因的重组复制缺陷型腺病毒(Ad-6Ckine)感染人外周血单个核细胞来源的DC,检测Ad-6Ckine-DC对6Ckine的表达及细胞因子分泌的影响,并观察其吞噬功能和表型的变化及对自身T淋巴细胞的趋化作用。用结肠癌LoVo细胞抗原致敏Ad-6Ckine-DC,将该DC与自身T淋巴细胞共同培养,分别用3H掺入法、RT-PCR和ELISA检测Ad-6Ckine-DC对T淋巴细胞增殖和分化的影响。结果在Ad-6Ckine转染后24h内,DC的吞噬功能几乎不受影响。转染的6Ckine基因能在DC中表达,表达的6Ckine能促进其表达CD83和CCR7,上调RANTES的表达。Ad-6Ckine-DC对自身T淋巴细胞有明显的趋化作用,抗原致敏的Ad-6Ckine-DC能显著促进T淋巴细胞的增殖,并增强其表达T-bet和IL-2的能力。结论6Ckine基因的修饰能在一定程度上促进DC的成熟,并募集T淋巴细胞于DC周围,有利于DC向T淋巴细胞传递抗原和第二信息,增强DC促进T淋巴细胞增殖的作用并使其向Th1分化,诱导细胞免疫,将成为制备肿瘤疫苗的一种良好选择。     

A mechanistic approach to modelling the risk of liver tumours in mice exposed to fumonisin B1 in the diet

Data from the National Toxicology Program's carcinogenesis study of fumonisin B₁ in B6C3F₁ mice, conducted at the National Center for Toxicological Research, were used to fit the Moolgavkar-Venzon-Knudson (MVK) two-stage, clonal-expansion model of carcinogenesis. In addition to tumour data from the conventional 2-year bioassay, the study included data on tissue weights, cell proliferation, cell death, and sphingolipid metabolism in primary target organs. The model was used to predict 2-year liver tumour rates in female and male mice based on differences among dose groups in the effect of fumonisin B₁ on the growth of normal tissue and on the proliferation of preneoplastic cells as a compensatory response to sphinganine-induced cell death. Fumonisin B₁ was assumed to be non-genotoxic, i.e. the model did not include any effect of fumonisin B₁ on either of the two mutation rates of the MVK model. The model was able to reproduce reasonably well the observed tumour rates in both female and male mice, predicting substantially increased rates above background only at the highest doses of fumonisin B₁ in females.     

Steps toward passively safe, proliferation-resistant nuclear power

After about a 30-year hiatus of construction in the US but not in all involved countries, the designs for an improved water-cooled nuclear reactor will hopefully be developed by a consortium of nuclear reactor builders and users under an agreement with the US Department of Energy (DOE) and review by the Nuclear Regulatory Commission (NRC). The construction of high-temperature, helium-cooled pebble-bed or prismatic reactors may herald the entry of new, safer, and less costly types of reactors to replace the water-cooled reactors of the past and current types. Nuclear breeder reactors hold the promise of limitless energy supplies without the use of fossil fuels or renewables at acceptable costs but this development program has been stalled periodically, especially in the US, when abundant low-cost uranium sources were added to the supply side.     

Proliferation resistance properties of u and Pu isotopes

The present study provides a quantitative basis for assessment of proliferation resistance properties of U and Pu isotopes.

Within the large area of issues covered by term of proliferation resistance, the only technical characteristics were chosen as a subject for discussion. The present study concentrates on intrinsic proliferation resistance features focusing the material characteristics associated with bare critical mass (BCM), decay heat (DH) and spontaneous-fission neutrons (SFN), which are treated as the main constituents of isotopic barriers against proliferation. The present study aims at determining major proliferation resistant attributes for U and Pu. This determination is largely based on analysis of their critical bare spheres. The MCNP code coupled with JENDL 3.2 data library is the main tool applied for this study. The other characteristics were summarized from the data available in scientific literature.     

低强度氦氖激光照射对小鼠胸腺细胞体外增殖的影响

目的 :研究低强度氦氖激光对体外培养的BALB/c小鼠胸腺细胞增殖的影响。方法 :采用MTT法检测不同功率密度、不同照射时间对不同起始培养密度小鼠胸腺细胞的增殖作用。结果 :低强度氦氖激光对小鼠胸腺细胞的增值有促进作用 ,当照射功率密度为 3.32 5mW /cm2 、照射时间 1～ 5分钟、起始细胞培养密度 2× 10 6个 /ml时效果最佳。结论 :低强度氦氖激光对小鼠胸腺细胞的增值有促进作用 ,促进小鼠胸腺细胞体外增殖的最佳条件为功率密度 3.32 5mW/cm2 、照射时间 1～ 5分钟、起始细胞培养密度 2× 10 6个 /ml,而照射时间超过 2 0min均会使细胞增殖受抑     

建筑的地域性因素

阐述了地域因素是贯穿建筑历史研究的一根线索，揭示出对于建筑地域性的研究，把建筑放在完整的社会、历史、环境背景中，是在动态中研究，指出建筑地域性的研究，对于建筑发展的多元化具有积极的意义。