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排序方式: 共有299条查询结果,搜索用时 15 毫秒
1.
YOSHIHARU KARIYA TADATOMO SUGA 《Fatigue & Fracture of Engineering Materials & Structures》2007,30(5):413-419
This paper details the deformation mechanism and low‐cycle fatigue life of eutectic solder alloys at high temperature (around 0.8Tm). Grain boundary sliding generally nucleates a wedge‐type cavity that reduces the low‐cycle fatigue life of metals. In this study, grain boundary sliding has promoted intergranular failure contributing to the reduction in fatigue life of Sn–Ag–Cu alloy. However, grain boundary sliding has exerted no deleterious effects on fatigue resistance of eutectic Pb–Sn and Bi–Sn alloys. The phase boundary sliding with very fine microstructure induces exceptional ductility in these alloys leading to superior low‐cycle fatigue endurance for theses eutectic Pb–Sn and Bi–Sn alloys. 相似文献
2.
Roberto Lande Immacolata Pietraforte Anna Mennella Raffaella Palazzo Francesca Romana Spinelli Konstantinos Giannakakis Francesca Spadaro Mario Falchi Valeria Riccieri Katia Stefanantoni Curdin Conrad Cristiano Alessandri Fabrizio Conti Loredana Frasca 《International journal of molecular sciences》2021,22(4)
LL37 acts as T-cell/B-cell autoantigen in Systemic lupus erythematosus (SLE) and psoriatic disease. Moreover, when bound to “self” nucleic acids, LL37 acts as “danger signal,” leading to type I interferon (IFN-I)/pro-inflammatory factors production. T-cell epitopes derived from citrullinated-LL37 act as better antigens than unmodified LL37 epitopes in SLE, at least in selected HLA-backgrounds, included the SLE-associated HLA-DRB1*1501/HLA-DRB5*0101 backgrounds. Remarkably, while “fully-citrullinated” LL37 acts as better T-cell-stimulator, it loses DNA-binding ability and the associated “adjuvant-like” properties. Since LL37 undergoes a further irreversible post-translational modification, carbamylation and antibodies to carbamylated self-proteins other than LL37 are present in SLE, here we addressed the involvement of carbamylated-LL37 in autoimmunity and inflammation in SLE. We detected carbamylated-LL37 in SLE-affected tissues. Most importantly, carbamylated-LL37-specific antibodies and CD4 T-cells circulate in SLE and both correlate with disease activity. In contrast to “fully citrullinated-LL37,” “fully carbamylated-LL37” maintains both innate and adaptive immune-cells’ stimulatory abilities: in complex with DNA, carbamylated-LL37 stimulates plasmacytoid dendritic cell IFN-α production and B-cell maturation into plasma cells. Thus, we report a further example of how different post-translational modifications of a self-antigen exert complementary effects that sustain autoimmunity and inflammation, respectively. These data also show that T/B-cell responses to carbamylated-LL37 represent novel SLE disease biomarkers. 相似文献
3.
The insecticidal nonprotein amino acid S-(-carboxyethyl)-cysteine (S-CEC) is the major free amino acid in the seeds of severalCalliandra spp. where it accounts for up to 2.9 % of dry weight. Lesser amounts of other related S-containing amino acids and an array of nonprotein imino acids derived from pipecolic acid are other constituents. High concentrations of imino acids, which also show insecticidal activity, are maintained in the mature leaves, but sulfur compounds are lacking. In this study the disappearance of S-CEC from the germinating seeds and young seedlings ofC. rubescens was monitored over time. After 10 weeks, S-CEC continues to be found in high concentrations in the stems and new leaves. As young leaves mature, sulfur compounds quickly decrease in concentration. Traces of S-CEC are found in new leaves of plants up to nine months after germination. Whether high concentration of S-CEC in young leaves is due to transportation from the seed or de novo synthesis is unclear. The ecological implications are discussed. 相似文献
4.
Most empirical investigations of the business cycles in the United States have excluded the dimension of asymmetric conditional volatility. This paper analyses the volatility dynamics of the US business cycle by comparing the performance of various multivariate generalised autoregressive conditional heteroskedasticity (GARCH) models. In particular, we propose two bivariate GARCH models to examine the evidence of volatility asymmetry and time-varying correlations concurrently, and then apply the proposed models to five sectors of Industrial Production of the United States. Our findings provide strong evidence of asymmetric conditional volatility in all sectors, and some support of time-varying correlations in various sectoral pairs. This has important policy implications for government to consider the effective countercyclical measures during recessions. 相似文献
5.
In this paper, two delayed SEIR epidemic models with continuous and impulsive vaccination and saturating incidence are investigated. The dynamical behaviors of the disease are analyzed. For continuous vaccination, we obtain a basic reproductive number R1 and prove that if R1≤1 then the disease-free equilibrium is globally attractive and if R1>1 then the disease is permanent by using the Lyapunov functional method. For impulsive vaccination, we obtain two thresholds R∗ and R∗ and prove that if R∗<1 then the disease-free periodic solution is globally attractive and if R∗>1 then the disease is permanent by using the comparison theorem of impulsive differential equation and the Lyapunov functional method. Lastly, we compared the effects of two vaccination strategies. 相似文献
6.
On the convective nature of the instability of a front undergoing a supercritical Turing bifurcation
Fronts are traveling waves in spatially extended systems that connect two different spatially homogeneous rest states. If the rest state behind the front undergoes a supercritical Turing instability, then the front will also destabilize. On the linear level, however, the front will be only convectively unstable since perturbations will be pushed away from the front as it propagates. In other words, perturbations may grow but they can do so only behind the front. It is of interest to show that this behavior carries over to the full nonlinear system. It has been successfully done in a case study by Ghazaryan and Sandstede [A. Ghazaryan, B. Sandstede, Nonlinear convective instability of Turing-unstable fronts near onset: a case study, SIAM J. Appl. Dyn. Syst. 6 (2007) 319–347]. In the present paper, analogous results are obtained for the same system as in Ghazaryan and Sandstede (2007), but for a different parameter regime. 相似文献
7.
Matthew R. Graham Author Vitae Author Vitae Raymond A. de Callafon Author Vitae 《Automatica》2009,45(6):1489-1496
This paper introduces an alternative formulation of the Kalman-Yakubovich-Popov (KYP) Lemma, relating an infinite dimensional Frequency Domain Inequality (FDI) to a pair of finite dimensional Linear Matrix Inequalities (LMI). It is shown that this new formulation encompasses previous generalizations of the KYP Lemma which hold in the case the coefficient matrix of the FDI does not depend on frequency. In addition, it allows the coefficient matrix of the frequency domain inequality to vary affinely with the frequency parameter. One application of this results is illustrated in an example of computing upper bounds to the structured singular value with frequency-dependent scalings. 相似文献
8.
分析了间接式胎压监测系统(TPMS)的不足,并基于FSK信号调制模式抗噪声强的特点,开发了一种新的直接式胎压监测系统.该系统由轮胎压力传感器和胎压控制器组成:轮胎压力传感器采用高集成复合芯片SP37实现轮胎内部压力、温度、加速度等信息的检测和发射,体积小、重量轻;胎压控制器以8位单片机控制射频接收器MC33596实现无线数据的接收、显示和报警.基于素数的动态延时算法和节能策略,降低了多个传感器同时发射时发生连续数据冲突的概率,在满足系统监测实时性的前提下延长了工作寿命.实车测试效果表明,该系统数据接收灵敏度可达到-100 dBm,在汽车时速100 km时工作很稳定. 相似文献
9.
研制了用于全面禁止核试验条约现场视察的移动式37Ar快速测量原型系统。进行了移动式37Ar快速测量原型系统演示活动。演示活动通过车载运输、模拟样品快速分离纯化测量、地下样品快速取样分离纯化测量、取样有效性四个场地试验和三次实验室验证测试,全面展示和验证了移动式37Ar快速测量原型系统的技术状态和性能指标。演示结果表明:移动式37Ar快速测量原型系统最小探测下限满足探测当量大于1kt的地下核试验的要求,且具有“机动、快速、小型”的特点,但系统仍需在降低探测限、增强稳定性和自动化程度等方面开展进一步研究工作。 相似文献
10.
CMOS器件p、γ、β辐照损伤等效剂量分析计算 总被引:1,自引:0,他引:1
建立了CMOS电子元器件中质子、电子和光子辐照损伤 (电子 空穴对和离位原子浓度 )计算模型。利用微机化的电子 光子簇射过程模拟程序EGS4和TRIM程序分别计算了电子 ( β)、光子 (γ)和质子 ( p)辐照在CMOS器件各层中产生的电子 空穴对和离位原子浓度。计算结果表明 ,在CMOS器件桥结绝缘层中 ,电子产生的电子 空穴对和离位原子浓度最高 ,光子次之 ,质子最低 ,这表明电子辐照损伤最高 ,光子次之 ,质子最小。 相似文献