排序方式: 共有5条查询结果,搜索用时 15 毫秒
1
1.
孙海清 《中国材料科技与设备》2009,6(1):5-7,10
缩氨基硫脲分子具有较高的生物活性,同时该类有机分子易与金属形成配合物,性能得到较大改善,可用作生物医药。所以以缩氨基硫脲分子为配体的配合物材料的研究是生物材料领域的一个热点。本文按照配体分子不同对缩氨基硫脲配合物材料的研究进展进行了分类综述,并对这类材料的发展趋势进行了探讨。 相似文献
2.
Anandaram Sreekanth Hoong-Kun Fun Maliyeckal R. Prathapachandra Kurup 《Inorganic chemistry communications》2004,7(12):1250-1253
The reaction between gold(III) chloride(AuCl3) and 2-benzoylpyridine N(4), N(4)-(butane-1,4-diyl) thiosemicarbazone (HBpypTsc) leads to an unexpected formation of a first gold(III) complex from an N(4)-disubstituted thiosemicarbazone derived from 2-benzoylpyridine. The crystal structure, spectroscopic characterization, and preliminary biological activity of [Au(III)(Cl)(BpypTsc)][Au(I)Cl2] complex are discussed herein. 相似文献
3.
The effects of benzoin (BN), benzil (BL), benzoin-(4-phenylthiosemicarbazone) (BN4PTSC) and benzil-(4-phenylthiosemicarbazone) (BL4PTSC) on the corrosion of mild steel in hydrochloric acid have been studied. Weight loss and hydrogen evolution measurements reveal that BN exhibit a higher maximum inhibition efficiency than BN4PTSC, BL and BL4PTSC. Generally, inhibition was found to increase with increase in inhibitor concentration and temperature. Chemical adsorption mechanism has been proposed for the inhibitors and the difference in the inhibition behaviour of the compounds has been explained in terms of the solubility of the compounds as well as the strength of the inhibitor–metal bond. 相似文献
4.
5.
Dr. Paulo André Teixeira de Moraes Gomes Prof. Marcos Veríssimo de Oliveira Cardoso Ignes Regina dos Santos Fabiano Amaro de Sousa Juliana Maria da Conceição Vanessa Gouveia de Melo Silva Denise Duarte Raquel Pereira Rafael Oliveira Prof. Fátima Nogueira Dr. Luiz Carlos Alves Dr. Fabio André Brayner Dr. Aline Caroline da Silva Santos Dr. Valéria Rêgo Alves Pereira Prof. Ana Cristina Lima Leite 《ChemMedChem》2020,15(22):2164-2175
Chagas disease and malaria are two neglected tropical diseases (NTDs) that prevail in tropical and subtropical regions in 149 countries. Chagas is also present in Europe, the US and Australia due to immigration of asymptomatic infected individuals. In the absence of an effective vaccine, the control of both diseases relies on chemotherapy. However, the emergence of parasite drug resistance is rendering currently available drugs obsolete. Hence, it is crucial to develop new molecules. Phthalimides, thiosemicarbazones, and 1,3-thiazoles have been used as scaffolds to obtain antiplasmodial and anti-Trypanosoma cruzi agents. Herein we present the synthesis of 24 phthalimido-thiosemicarbazones ( 3 a – x ) and 14 phthalimido-thiazoles ( 4 a – n ) and the corresponding biological activity against T. cruzi, Plasmodium falciparum, and cytotoxicity against mammalian cell lines. Some of these compounds showed potent inhibition of T. cruzi at low cytotoxic concentrations in RAW 264.7 cells. The most active compounds, 3 t (IC50=3.60 μM), 3 h (IC50=3.75 μM), and 4 j (IC50=4.48 μM), were more active than the control drug benznidazole (IC50=14.6 μM). Overall, the phthalimido-thiosemicarbazone derivatives were more potent than phthalimido-thiazole derivatives against T. cruzi. Flow cytometry assay data showed that compound 4 j was able to induce necrosis and apoptosis in trypomastigotes. Analysis by scanning electron microscopy showed that T. cruzi trypomastigote cells treated with compounds 3 h , 3 t , and 4 j at IC50 concentrations promoted changes in the shape, flagella, and surface of the parasite body similar to those observed in benznidazole-treated cells. The compounds with the highest antimalarial activity were the phthalimido-thiazoles 4 l (IC50=1.2 μM), 4 m (IC50=1.7 μM), and 4 n (IC50=2.4 μM). Together, these data revealed that phthalimido derivatives possess a dual antiparasitic profile with potential effects against T. cruzi and lead-like characteristics. 相似文献
1