基于VPM系统平台的厂房机电三维协同设计应用

随着水电站建设周期缩短和设计产品质量要求提高,水电站设计领域各专业越来越需要在跨专业的基于网络化和信息共享的平台上进行三维协同设计。CATIA软件及其协同管理模块VPM系统平台能满足水电站厂房机电三维协同设计的要求,其骨架设计思想、设计关联性和参数化设计特别适用于工程可研、初设和技施阶段三维设计和方案的变更。     

Path integration and lesions within the head direction cell circuit: Comparison between the roles of the anterodorsal thalamus and dorsal tegmental nucleus.

Experiments were designed to determine whether 2 regions of the head direction cell circuit, the anterodorsal thalamic nucleus (ADN) and the dorsal tegmental nucleus (DTN), contribute to navigation. Rats were trained to perform a food-carrying task with and without blindfolds prior to receiving sham lesions or bilateral lesions of the ADN or DTN. ADN-lesioned rats were mildly impaired in both versions of the task. DTN-lesioned rats, however, were severely impaired and showed reduced heading accuracy in both task versions. These findings suggest that although both the DTN and ADN contribute to navigation based on path integration and landmarks, disruption of the head direction cell circuit at the level of the DTN has a significantly greater effect on spatial behavior than lesions of the ADN. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Long-term functional outcome following transient middle cerebral artery occlusion in the rat: Correlation between brain damage and behavioral impairment.

The assessment of both histological and functional long-term outcomes after cerebral ischemia is increasingly recommended for preclinical studies. Whereas correlations between behavioral impairments and primary ischemic lesion are documented, little is known about their relationships with remote nonischemic regions that undergo secondary degeneration, such as the thalamus. Anesthetized rats were subjected to mild (30 min) or severe (60 min) occlusion of the middle cerebral artery. Two months after ischemia, sensorimotor behavior was assessed according to the neurological score, limb-placing, adhesive-removal, and staircase tests; the final histological lesion was measured after this assessment. Cortical damage was correlated to all transient and long-lasting sensorimotor deficits, whereas striatal lesion was more consistently reflected by the forelimb-placing reflexes and adhesive-removal motor deficits. By contrast, the thalamic atrophy was not correlated to early neurological impairment, but rather to the late sensory deficit at the adhesive-removal test and to the skilled forepaw reaching alteration at the staircase test. This suggests that thalamus contributes, albeit moderately, to the ischemia-induced long-lasting sensorimotor deficits, some of which represent relevant targets for therapeutic interventions. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The Role of the Thalamus in Post-Traumatic Stress Disorder

Post-traumatic stress disorder (PTSD) has a high lifetime prevalence and is one of the more serious challenges in mental health care. Fear-conditioned learning involving the amygdala has been thought to be one of the main causative factors; however, recent studies have reported abnormalities in the thalamus of PTSD patients, which may explain the mechanism of interventions such as eye movement desensitization and reprocessing (EMDR). Therefore, I conducted a miniature literature review on the potential contribution of the thalamus to the pathogenesis of PTSD and the validation of therapeutic approaches. As a result, we noticed the importance of the retinotectal pathway (superior colliculus−pulvinar−amygdala connection) and discussed therapeutic indicators.     

Squeezing flow of MHD fluid between parallel disks

Squeezing flow between parallel disks is studied for the case when one disk is porous and the other is impermeable. Viable similarity transform is used to reduce the problem to a highly nonlinear ordinary differential equation. Variation of Parameters Method (VPM) is then employed to determine the solution to resulting ordinary differential equation. Numerical solution is also obtained using R-K 4 method and comparison shows an excellent agreement between both the solutions. Effects of different physical parameters on the flow are also discussed with the help of graphs coupled with comprehensive discussions.     

The role of prefrontal cortex in predictive fear learning.

Pavlovian fear conditioning depends on prediction error, or the discrepancy between actual and expected outcomes. We used immunohistochemistry, neuronal tract tracing, and reversible inactivation to study the role of prefrontal cortex and thalamocortical pathways in predictive fear learning. Unexpected, but not expected, conditioned stimulus (CS)–unconditioned stimulus (US) presentations caused increased c-Fos expression in the prefrontal cortex (PFC), midline thalamus, lateral amygdala, as well as retrograde labeled midline thalamic afferents to PFC. Reversible inactivation of dorsomedial PFC, but not infralimbic PFC, prevented the associative blocking of fear learning. These results suggest a role for dorsomedial PFC (dmPFC), and a thalamic → dmPFC pathway, in signaling whether or not aversive events are expected or unexpected and so whether they are to be learned about. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The formation of cognitive maps of adjacent environments: Evidence from the head direction cell system.

In 2 experiments the authors tested whether the head direction (HD) cell system underlies a sense of direction maintained across environments. In Experiment 1, HD neurons failed to maintain their firing directions across T mazes in adjacent environments but rather reoriented to the T maze within each environment. Such reorientation suggests that familiar landmarks override an internal directional sense, so in Experiment 2 the authors recorded HD neurons as rats walked between novel and familiar "rooms" of a 4-chamber apparatus. In novel rooms, HD neurons maintained the firing direction of the preceding environment. However, in familiar rooms, HD neuron firing directions shifted to agree with the landmarks therein. With repeated experience, a homogeneous representation of all rooms developed in a subset of the rats. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

基于Enovia VPM的水利水电行业机电协同设计研究

针对水利水电行业机电协同并行设计问题,基于Enovia VPM协同设计平台,首先按照协同设计思想合理分配机电专业设计人员的角色与任务,然后探讨定制水利水电行业的机电客户化环境,并以实例说明建立机电模型库和将其保存到Enovia VPM平台的方法,最后研究在引用专业骨架并参考借用厂房坐标和模型条件下完成机电协同并行设计的实施方法。水电站机电协同设计应用实践表明:该方法能够很好地实现机电专业的实时协同并行设计,能缩短工期并减轻设计人员劳动强度,同时便于设计方案的变更与优化,也使得水利水电行业机电设计经验更好地被传承和创新。     

ENOVIA V5 VPM在吉林院的应用

本文简单介绍了 ENOVIA VPM 三维协同设计平台及其架构,通过对 VPM 角色的讲解,接合中部供水项目,进行吉林院多专业协同设计的案例展示。     

基于目标成本法的模块化产品变型设计研究

将成本设计理念应用于模块化产品变型设计进行了研究,建立了产品模块化变型设计的目标成本控制模型和流程,实现了产品模块化变型设计过程中功能满足,冗余成本降低的要求,提高了模块化产品的设计效率以及加快了产品的上市时间.