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Julie K. Furmick Dr. Ichiro Kaneko Angela N. Walsh Joanna Yang Jaskaran S. Bhogal Geoffrey M. Gray Juan C. Baso Drew O. Browder Jessica L. S. Prentice Luis A. Montano Chanh C. Huynh Lisa M. Marcus Dorian G. Tsosie Jungeun S. Kwon Alexis Quezada Nicole M. Reyes Brittney Lemming Puneet Saini Dr. Arjan van der Vaart Dr. Thomas L. Groy Dr. Pamela A. Marshall Dr. Peter W. Jurutka Dr. Carl E. Wagner 《ChemMedChem》2012,7(9):1551-1566
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Julie K. Furmick Dr. Ichiro Kaneko Angela N. Walsh Joanna Yang Jaskaran S. Bhogal Geoffrey M. Gray Juan C. Baso Drew O. Browder Jessica L. S. Prentice Luis A. Montano Chanh C. Huynh Lisa M. Marcus Dorian G. Tsosie Jungeun S. Kwon Alexis Quezada Nicole M. Reyes Brittney Lemming Puneet Saini Dr. Arjan van der Vaart Dr. Thomas L. Groy Dr. Pamela A. Marshall Dr. Peter W. Jurutka Dr. Carl E. Wagner 《ChemMedChem》2012,7(9):1510-1510
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Przemysaw Haubiec Agnieszka azarczyk Oskar Szafraski Torsten Bohn Joanna Duliska-Litewka 《International journal of molecular sciences》2021,22(19)
Prostate cancer (PC) is the second most common tumor in males. The search for appropriate therapeutic options against advanced PC has been in process for several decades. Especially after cessation of the effectiveness of hormonal therapy (i.e., emergence of castration-resistant PC), PC management options have become scarce and the prognosis is poor. To overcome this stage of disease, an array of natural and synthetic substances underwent investigation. An interesting and promising class of compounds constitutes the derivatives of natural retinoids. Synthesized on the basis of the structure of retinoic acid, they present unique and remarkable properties that warrant their investigation as antitumor drugs. However, there is no up-to-date compilation that consecutively summarizes the current state of knowledge about synthetic retinoids with regard to PC. Therefore, in this review, we present the results of the experimental studies on synthetic retinoids conducted within the last decade. Our primary aim is to highlight the molecular targets of these compounds and to identify their potential promise in the treatment of PC. 相似文献
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