Systemic Inflammation and the Breakdown of Intestinal Homeostasis Are Key Events in Chronic Spinal Cord Injury Patients

Our aim was to investigate the subset distribution and function of circulating monocytes, proinflammatory cytokine levels, gut barrier damage, and bacterial translocation in chronic spinal cord injury (SCI) patients. Thus, 56 SCI patients and 28 healthy donors were studied. The levels of circulating CD14^+highCD16⁻, CD14^+highCD16⁺, and CD14^+lowCD16⁺ monocytes, membrane TLR2, TLR4, and TLR9, phagocytic activity, ROS generation, and intracytoplasmic TNF-α, IL-1, IL-6, and IL-10 after lipopolysaccharide (LPS) stimulation were analyzed by polychromatic flow cytometry. Serum TNF-α, IL-1, IL-6 and IL-10 levels were measured by Luminex and LPS-binding protein (LBP), intestinal fatty acid-binding protein (I-FABP) and zonulin by ELISA. SCI patients had normal monocyte counts and subset distribution. CD14^+highCD16⁻ and CD14^+highCD16⁺ monocytes exhibited decreased TLR4, normal TLR2 and increased TLR9 expression. CD14^+highCD16⁻ monocytes had increased LPS-induced TNF-α but normal IL-1, IL-6, and IL-10 production. Monocytes exhibited defective phagocytosis but normal ROS production. Patients had enhanced serum TNF-α and IL-6 levels, normal IL-1 and IL-10 levels, and increased circulating LBP, I-FABP, and zonulin levels. Chronic SCI patients displayed impaired circulating monocyte function. These patients exhibited a systemic proinflammatory state characterized by enhanced serum TNF-α and IL-6 levels. These patients also had increased bacterial translocation and gut barrier damage.     

Botulinum Toxin: From Poison to Possible Treatment for Spasticity in Spinal Cord Injury

Botulism has been known for about three centuries, and since its discovery, botulinum toxin has been considered one of the most powerful toxins. However, throughout the 20th century, several medical applications have been discovered, among which the treatment of spasticity stands out. Botulinum toxin is the only pharmacological treatment recommended for spasticity of strokes and cerebral palsy. Although its use as an adjuvant treatment against spasticity in spinal cord injuries is not even approved, botulinum toxin is being used against such injuries. This article describes the advances that have been made throughout history leading to the therapeutic use of botulinum toxin and, in particular, its application to the treatment of spasticity in spinal cord injury.     

Perceived risk for influenza in veterans with spinal cord injuries and disorders.

Objective: Guided by the extended parallel process model (EPPM), the objective was to assess control processes dominant in influenza behavior decisions. Design: Cross-sectional survey. Results: Response rate was 31% (n=968). Regarding influenza risk, 59% were in danger control. Those in fear control were more likely to report influenza infection (p=.000). In the nonvaccinated, those in fear control were more likely to indicate not knowing where to get the vaccine (p=.016) and that it was unavailable (p=.027), and those in danger control believed they did not need it (p=.023). Zero critical values were more likely to indicate that no health provider recommended the shot (p=.002). Conclusions: Most perceived efficacy to be stronger than threat related to influenza; according to the EPPM, they are aware of their risk but recognize their ability to avert it. For those in danger control, messages should focus on increasing perceptions of severity and susceptibility to positively affect behavior change. For those in fear control, messages should focus on efficacy only. With a critical value of zero, no threat is induced, and a high-threat/high-efficacy approach should be taken. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

氟挥发对氟化物乳白玻璃瓶罐生产的影响

氟挥发对氟化物乳白玻璃瓶罐生产的影响陆德明，周俊梅，付希英（山东轻工业学院２５０１００）（山东德州玻璃厂２５３０１９）ＴｈｅＩｎｆｌｕｅｎｃｅｏｆＦｌｕｏｒｉｎｅＶｏｌａｔｉｌｉｚａｔｉｏｎｏｎＰｒｏｄｕｃｔｉｏｎｏｆＦｌｕｏｒｉｄｅｏｐａｌＧｌａｓ...     

éditorial.

This issue begins with an invited paper by Ronald Melzack, continuing the "Distinguished Contribution Series" begun in 1990 by my predecessor, Gordon Winocur. Professor Melzack is known world-wide for his research on pain. In 1965, together with Patrick Wall, he proposed the gate control theory, an entirely new conception of pain. For the first time, there was an explicit physiological model emphasizing the role played by the brain as well as by the spinal cord, leading to a new integration of psychological and physiological contributions to pain, as well as to new avenues for the control of pain. This theory has been highly influential, as a quick look in virtually any textbook in biology or medicine will confirm. Professor Melzack's continuing development of his ideas is presented with remarkable clarity in his books and in his many journal articles. It is, therefore, especially exciting for CJEP to be the first to publish a sketch of his new neuromatrix theory. When the book developing this theory is published, it too will no doubt have an immediate and major impact. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

我国锦纶帘子布市场发展态势及对策

通过对我国当前帘布市场态势的分析和今后三年的需求预测，探讨了锦纶帘线的生产发展对策。认为“八五”期间，我国锦纶帘布市场将呈现供大于求的局面，在一段时期内，锦纶帘布仍将是主要的橡胶骨架材料，其占比例为７０％左右。预计１９９３～１９９５年，锦纶橡胶骨架材料的市场需求量分别为９．１６，１０．３７．１１．６９万ｔ。     

2＋2×0.32ST超高强度钢丝帘线在半钢子午线轮胎带束层中的应用

研究2+2×0.32ST钢丝帘线替代2+2×0.35HT钢丝帘线在半钢子午线轮胎带束层中的应用。结果表明:与2+2×0.35HT钢丝帘线相比,2+2×0.32ST钢丝帘线的强度更高、直径更小、耐疲劳性能更好;在轮胎带束层中用2+2×0.32ST钢丝帘线替代2+2×0.35HT钢丝帘线后,工艺性能良好,成品轮胎的充气外缘尺寸变化不大,强度性能、高速性能、耐久性能和耐水压性能均能满足设计和国家标准要求,滚动阻力降低,同时有效减小了轮胎中的钢丝帘线和胶料用量,降低了生产成本。     

Human-Induced Neural and Mesenchymal Stem Cell Therapy Combined with a Curcumin Nanoconjugate as a Spinal Cord Injury Treatment

We currently lack effective treatments for the devastating loss of neural function associated with spinal cord injury (SCI). In this study, we evaluated a combination therapy comprising human neural stem cells derived from induced pluripotent stem cells (iPSC-NSC), human mesenchymal stem cells (MSC), and a pH-responsive polyacetal–curcumin nanoconjugate (PA-C) that allows the sustained release of curcumin. In vitro analysis demonstrated that PA-C treatment protected iPSC-NSC from oxidative damage in vitro, while MSC co-culture prevented lipopolysaccharide-induced activation of nuclear factor-κB (NF-κB) in iPSC-NSC. Then, we evaluated the combination of PA-C delivery into the intrathecal space in a rat model of contusive SCI with stem cell transplantation. While we failed to observe significant improvements in locomotor function (BBB scale) in treated animals, histological analysis revealed that PA-C-treated or PA-C and iPSC-NSC + MSC-treated animals displayed significantly smaller scars, while PA-C and iPSC-NSC + MSC treatment induced the preservation of β-III Tubulin-positive axons. iPSC-NSC + MSC transplantation fostered the preservation of motoneurons and myelinated tracts, while PA-C treatment polarized microglia into an anti-inflammatory phenotype. Overall, the combination of stem cell transplantation and PA-C treatment confers higher neuroprotective effects compared to individual treatments.     

涤纶帘子线的等离子体改性

运用等离子体对涤纶帘子线进行改性处理，从而提高涤纶帘子线与橡胶的粘合性，并用X光电子能谱和红外光谱表面分析技术分析改性后的涤纶帘子线表面结构所发生的变化。     

锦纶66浸胶帘子布生产中的张力与控制

分析了帘子布生产中张力的作用及各区段的张力情况。张力应根据生产品种及浸胶帘子布的内在质量要求来选择，一般张力设定依据为拉伸区张力是干燥区张力的１倍，定型区张力是拉伸区张力的０．６５倍。同时应控制好各区段的温度，降低拉伸应力使锦纶６６帘子布拉伸均匀，提高帘子布的物理性能。