Defect Detection from Visual Abnormalities in Manufacturing Process Using IDDQ

Abnormal I _DDQ (Quiescent V _DD supply current) indicates the existence of physical damage in a circuit. Using this phenomenon, a CAD-based fault diagnosis technology has been developed to enhance the manufacturing yield of logic LSI. This method to detect the fatal defect fragments in several abnormalities identified with wafer inspection apparatus includes a way to separate various leakage faults, and to define the diagnosis area encircling the abnormal portions. The proposed technique progressively narrows the faulty area by using logic simulation to extract the logic states of the diagnosis area, and by locating test vectors related to abnormal I _DDQ. The fundamental diagnosis way employs the comparative operation of each circuit element to determine whether the same logic state with abnormal I _DDQ exists in normal logic state or not.     

The heterosexual affectional system in monkeys.

"We believe that the heterosexual affectional system in the rhesus monkey, like all the other affectional systems, goes through a series of developmental stages—an infantile heterosexual stage, a preadolescent stage, and an adolescent and mature heterosexual stage." Isolation-raised monkeys later displayed severe social abnormalities—a sociopathic syndrome. Monkeys raised with surrogate mothers—rejecting wire frame mothers, air-blast mothers, and infant-shaking mothers—have seldom displayed normal sex behavior. "Month after month female monkeys that never knew a real mother, themselves become mothers—helpless, hopeless, heartless mothers devoid, or almost devoid of any maternal feeling." (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Long-term effects of neonatal medial temporal ablations on socioemotional behavior in monkeys (Macaca mulatta).

Socioemotional abnormalities, including decreased social interactions and increased self-directed activity, were reported when rhesus monkeys with neonatal ablations of either the medial temporal lobe (AH) or the inferior temporal cortex (TE) were paired with unoperated peers at two and six months of age, though these abnormalities were more severe in Group AH (Bachevalier et al., 2001). As adults (Experiment 1), the monkeys were re-evaluated in the same dyads and their reactivity to novel toys, social status, and reactions to separation were also assessed. Group TE now showed only few if any of the abnormal behaviors observed in infancy. In contrast, Group AH continued to display decreased social interactions and increased self-directed activity and showed also increased submission and reduced responses to separation, but normal reactivity to novel toys. To determine whether this degree of socioemotional impairment was less severe than that produced by the same damage in adulthood, we assessed dyadic social interactions of monkeys raised until adulthood in laboratory conditions similar to those in Experiment 1 and then given the AH ablations (Experiment 2). Two months postoperatively these monkeys showed a small reduction in social interactions that became more pronounced six months postoperatively, yet remained less severe than that seen in the infant-lesioned monkeys. No other socioemotional effects, except for an increase in food/water consumption, were observed. The finding that neonatal AH lesions produce more severe socioemotional disturbances than the same lesion in adulthood is the reverse of the effect commonly reported for other cognitive functions after cerebral damage. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Motor sequencing deficits in schizophrenia: A comparison with Parkinson's disease.

Motor abnormalities occur in schizophrenia (SZ) and may arise from striatal dysfunction. This study examined whether the pattern of performance on simple and complex motor abilities in SZ was similar to that of patients with Parkinson's disease (PD). Quantitative tests of speeded movement and motor and cognitive sequencing were used to assess 25 SZ, 16 PD, and 84 normal controls (NCs). Sequencing performance was also examined with motor rigidity taken into account. Compared with the NC group, the SZ and PD groups were impaired on measures of motor rigidity and motor sequencing. With rigidity accounted for, the SZ group was significantly more impaired than the PD group on motor sequencing; cognitive and motor processes contributed to the motor deficit. Cognitive sequencing performance predicted motor sequencing performance in PD but not SZ. Although both SZ and PD resulted in significant motor and cognitive sequencing deficits, the pattern and correlates of these deficits differ, suggesting that the affected neural systems underlying motor deficits in SZ are different from those involved in PD. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

585nm脉冲染料激光治疗皮肤血管性疾病所致的副作用

目的:观察585nm脉冲染料激光治疗血管性疾病所致的副作用。方法:分析500例经585nm脉冲染料激光治疗后的副反应。结果:500例接受治疗的患者中发生副反应者89例。其中色素沉着35例、色素减退12例、萎缩性瘢痕40例、增生性瘢痕2例。出现副反应与疾病种类、治疗能量无关,与治疗次数有关。结论:585nm脉冲染料激光治疗血管性疾病无连续激光治疗后所致的增生性瘢痕、持续性色素沉着等副作用,用于治疗血管性疾病是比较安全的。     

自然流产的细胞遗传学研究进展

自然流产是妊娠并发症,指妊娠在28周之前自然终止,其发病率在15%~40%。近年来在辅助生育技术的使用中,同样面临着较高的自然流产率的问题。自然流产的病因十分复杂,除了遗传因素以外,还包括解剖因素、内分泌因素、感染因素、环境因素、免疫因素、血栓前状态以及母体的全身性疾病等等。自然流产的细胞遗传学研究,主要在两个方面,一是胚胎染色体的异常,包括染色体数量异常和结构异常;二是夫妇染色体的异常。在自然流产中胚胎染色体异常的检出率在60%左右,且随着流产次数的增加,染色体异常的比例下降。其中大部分为胚胎染色体数目异常如三体、三倍体及X单体等,较少为染色体结构异常,包括染色体断裂、倒置、缺失和易位等。在自然流产的夫妇中,尤其是反复自然流产的夫妇,其染色体异常的检出率在8%左右,且随着流产次数的增加异常的比例升高。成人染色体的异常多为染色体的平衡易位。随着细胞遗传学的检测技术的发展,从传统染色体核型分析和荧光原位杂交技术到染色体微阵列芯片分析、第二代测序技术即高通量测序技术的相继应用,使得自然流产的遗传学方面的研究更加深入。自然流产的细胞遗传学的研究进展,对于自然流产的病因研究以及生育指导有着非常重要的意义。