Design of Trehalose-Based Amide/Sulfonamide C-type Lectin Receptor Signaling Compounds

Mincle agonists have been shown to induce inflammatory cytokine production, such as tumor necrosis factor-alpha (TNF) and promote the development of a Th1/Th17 immune response that might be crucial to development of effective vaccination against pathogens such as Mycobacterium tuberculosis. As an expansion of our previous work, a library of 6,6′-amide and sulfonamide α,α-d -trehalose compounds with various substituents on the aromatic ring was synthesized efficiently in good to excellent yields. These compounds were evaluated for their ability to activate the human C-type lectin receptor Mincle by the induction of cytokines from human peripheral blood mononuclear cells. A preliminary structure–activity relationship (SAR) of these novel trehalose diamides and sulfonamides revealed that aryl amide-linked trehalose compounds demonstrated improved activity and relatively high potency cytokine production compared to the Mincle ligand trehalose dibehenate adjuvant (TDB) and the natural ligand trehalose dimycolate (TDM) inducing dose-dependent and human-Mincle-specific stimulation in a HEK reporter cell line.     

调节性B细胞在自身免疫性溶血性贫血患者外周血中的表达及临床意义

目的: 探讨自身免疫性溶血性贫血（AIHA）患者外周血中调节性B细胞（Bregs）的表达及其在该病发病中的意义。方法:选择16例自身免疫性溶血性贫血患者和14例健康志愿者为研究对象，用流式细胞术分析外周血CD19+IL-10+调节性B细胞及CD19+CD24hiCD27+调节性B细胞的表达；ELISA方法检测培养上清液中IL-10的水平。结果:自身免疫性溶血性贫血患者外周血中CD19+IL-10+调节性B细胞、CD19+CD24hiCD27+调节性B细胞的表达分别为（1.27±0.39）％、（9.85±2.18）％，健康志愿者组分别为（2.92±0.71）％、（26.47±4.31）％，两组比较差异有统计学意义（P<0.05）；自身免疫性溶血性贫血患者细胞培养上清中IL-10的水平低于健康志愿者组（P<0.05）。结论:自身免疫性溶血性贫血患者外周血中CD19+IL-10+调节性B细胞及CD19+CD24hiCD27+调节性B细胞比例降低，提示调节性B细胞可能参与自身免疫性溶血性贫血的发病过程。     

Effect of Synergistic Anticorrosion Treatments on Cycling Stability of Mg-Based Hydrogen Storage Electrode

In this paper, any two of the three anticorrosion agents, that is emulsifier (OP-10), soluble glass (Na2O·nSiO2) and glycerin (C3H8O3), were treated simultaneously on the surface of amorphous (a-) MgNi+5% Ml2Mg17 (Ml denotes the lanthanum-rich mish metal) electrode and the electrolyte. Effect of the synergistic anticorrosion treatment on charging/discharging cycle stability of the electrode was investigated. Contrasted with single treatment method, the cycling stability of the electrodes was further improved. The desirable synergistic anticorrosion method was that the electrode was treated by the soluble glass, and that OP-10 was added into the electrolyte. The cyclic voltammogram (CV) results of the electrode show clearly that the anticorrosion agent can change the electrochemical activity and mechanism of the electrode. The concentration of the anticorrosion agent in the electrolyte treated by the synergistic anticorrosion method was also investigated. The appropriate concentration of the anticorrosion agents in the electrolyte is 0.143%.     

Microstructural Investigation on Failure of Internal Drive Shaft

17-4 PH stainless steel is used as internal drive shaft material in liquid engine pumps. One of the drive shafts failed during operation. The shaft pieces were in contact for short duration after failure, which has resulted in abrasion of fractured surfaces. Samples from the location of failure were taken, and investigation of the failure was carried out using optical and scanning electron microscopy. The microstructural analysis of the material and fractographic analysis of the fractured surface show that the failure was caused by excessive torsion.     

^17O系统的R矩阵分析

采用多道多能级R矩阵理论,全面系统地分析~(17)O系统中10.5 MeV激发能以下有关~(16)O(n,n)~(16)O·~(16)O(n,a)~(13)C和~(13)C(a,a)~(13)C的全部实验数据。有关~(16)O的中子反应截面计算值被收入中国评价数据库CENDL-2和美国的评价数据库ENDF/B-6。对在R矩阵分析中如何确定本底、道半径和边界条件等问题予以讨论。     

Religious Participation, Interleukin-6, and Mortality in Older Adults.

This study prospectively examined the relationship between religious attendance, interleukin-6 (IL-6) levels, and mortality rates in a community-based sample of 557 older adults. Attending religious services more than once weekly was a significant predictor of lower subsequent 12-year mortality and elevated IL-6 levels (> 3.19 pg/mL), with a mortality ratio of .32 (95% confidence interval [CI] = 0.15,0.72; p     

新型高温永磁体的研制

通过分析影响磁体高温性能的因素,设计了新磁体的成分为:Cu含量高,Fe含量低,Zr适量,Sm含量高;采用粉末冶金工艺制备了高温Sm_2(CoFeCuZr)_(17)永磁体。制得的磁体室温磁性能为:B_r1.075 T,H_(ei)2 098.2 kA/m,H_(eb) 776.1 kA/m,H_k843.8 kA/m,(BH)_(max)210.0 kj/m~3;在200℃时的磁性能为:B_r0.991 T,H_(ci)1 175.7 kA/m,H_(cb)531.7 kA/m,H_k577.9 kA/m,(BH)_(max)172.5 kJ/m~3;矫顽力温度系数β(20～200℃)为-0.24％/℃。经理论分析和实验验证,磁体的使用温度均超过400℃,为高温环境(高于400℃)提供了一种实用性永磁材料。