抗辐照合金的发展与纳米结构ODS钢的抗辐照性能

简要介绍了抗辐照合金的发展,合金微观结构对合金抗辐照性能的影响,先进堆核心部件结构材料最佳的备选材料纳米结构氧化物弥散强化钢的特征性微观结构及其抗辐照性能.     

Improvements on radiation-hardened performance of static induction transistor

The radiation-hardened performances of static induction transistor (SIT) have been studied in depth in this paper. The effects of radiation of electron beam on the I-V characteristics, carrier distribution and potential distribution in the channel of SIT have been represented. A large number of electron-hole pairs are generated in the depletion region of reversely biased gate-channel PN junction. The radiation-generated electrons drift towards the drain region at high positive potential, while generated hol...     

一种基于编码的存储器加固设计

在太空辐射环境中存在各种宇宙射线和一些高能粒子,其中单粒子翻转（SEU）效应是引起存储器软错误的重要因素,降低了数据传输的可靠性,因此成为当前集成电路抗辐射加固设计的研究重点之一。标准的纠错编码（ECC）设计冗余度将占用超过50%的存储量,该设计基于缩短汉明码的原理实现了对32位存储器采用7位冗余码进行纠错编码的SEC-DED加固设计,在资源上得到了优化;同时从概率的角度分析了可靠性的理论基础,通过编码可靠性可以提高3到6个数量级。     

Activated ERK Signaling Is One of the Major Hub Signals Related to the Acquisition of Radiotherapy-Resistant MDA-MB-231 Breast Cancer Cells

Breast cancer is one of the major causes of deaths due to cancer, especially in women. The crucial barrier for breast cancer treatment is resistance to radiation therapy, one of the important local regional therapies. We previously established and characterized radio-resistant MDA-MB-231 breast cancer cells (RT-R-MDA-MB-231 cells) that harbor a high expression of cancer stem cells (CSCs) and the EMT phenotype. In this study, we performed antibody array analysis to identify the hub signaling mechanism for the radiation resistance of RT-R-MDA-MB-231 cells by comparing parental MDA-MB-231 (p-MDA-MB-231) and RT-R-MDA-MB-231 cells. Antibody array analysis unveiled that the MAPK1 protein was the most upregulated protein in RT-R-MDA-MB-231 cells compared to in p-MDA-MB-231 cells. The pathway enrichment analysis also revealed the presence of MAPK1 in almost all enriched pathways. Thus, we used an MEK/ERK inhibitor, PD98059, to block the MEK/ERK pathway and to identify the role of MAPK1 in the radio-resistance of RT-R-MDA-MB-231 cells. MEK/ERK inhibition induced cell death in both p-MDA-MB-231 and RT-R-MDA-MB-231 cells, but the death mechanism for each cell was different; p-MDA-MB-231 cells underwent apoptosis, showing cell shrinkage and PARP-1 cleavage, while RT-R-MDA-MB-231 cells underwent necroptosis, showing mitochondrial dissipation, nuclear swelling, and an increase in the expressions of CypA and AIF. In addition, MEK/ERK inhibition reversed the radio-resistance of RT-R-MDA-MB-231 cells and suppressed the increased expression of CSC markers (CD44 and OCT3/4) and the EMT phenotype (β-catenin and N-cadherin/E-cadherin). Taken together, this study suggests that activated ERK signaling is one of the major hub signals related to the radio-resistance of MDA-MB-231 breast cancer cells.     

防辐射大体积混凝土施工

介绍了太铁中心医院直线加速器机房的施工过程，为解决好防辐射大体积混凝土的施工，介绍了所采取的科学有效的施工方法及措施，使防辐射大体积混凝土的施工质量各项指标达到了设计要求。     

Electrical and mechanical properties of thermoplastic polyimide-insulated coaxial cable for use under high-temperature and radioactive conditions

Thermoplastic polyimide-insulated coaxial cable for use under high-temperature and radioactive conditions was developed and its electrical and mechanical properties were evaluated in comparison with cable insulated with polyetheretherketone which is known for its superior heat- and radiation-resistant characteristics. According to experiments, the electrical properties of thermoplastic polyimide-insulated cable are stable over a wider temperature range in comparison with polyetheretherketone-insulated cable even after 1.2 MGy of γ-ray irradiation and 6-months heat aging at 220°C, indicating that thermoplastic polyimide is superior for use as a heat- and radiation-resistant cable-covering material. The electrical properties of TPI cable observed, were within actual use requirements, even under γ-ray irradiation up to 1000 Gy/h.