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1.
Guglielmina Chimienti Anna Picca Flavio Fracasso Francesco Russo Antonella Orlando Giuseppe Riezzo Christiaan Leeuwenburgh Vito Pesce Angela Maria Serena Lezza 《International journal of molecular sciences》2021,22(4)
Calorie restriction (CR) is the most efficacious treatment to delay the onset of age-related changes such as mitochondrial dysfunction. However, the sensitivity of mitochondrial markers to CR and the age-related boundaries of CR efficacy are not fully elucidated. We used liver samples from ad libitum-fed (AL) rats divided in: 18-month-old (AL-18), 28-month-old (AL-28), and 32-month-old (AL-32) groups, and from CR-treated (CR) 28-month-old (CR-28) and 32-month-old (CR-32) counterparts to assay the effect of CR on several mitochondrial markers. The age-related decreases in citrate synthase activity, in TFAM, MFN2, and DRP1 protein amounts and in the mtDNA content in the AL-28 group were prevented in CR-28 counterparts. Accordingly, CR reduced oxidative mtDNA damage assessed through the incidence of oxidized purines at specific mtDNA regions in CR-28 animals. These findings support the anti-aging effect of CR up to 28 months. Conversely, the protein amounts of LonP1, Cyt c, OGG1, and APE1 and the 4.8 Kb mtDNA deletion content were not affected in CR-28 rats. The absence of significant differences between the AL-32 values and the CR-32 counterparts suggests an age-related boundary of CR efficacy at this age. However, this only partially curtails the CR benefits in counteracting the generalized aging decline and the related mitochondrial involvement. 相似文献
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3.
Overview of ship-design expert systems 总被引:1,自引:0,他引:1
Expert systems constitute a branch of artificial intelligence, and their unique characteristics enable computer systems to perform at the level of a human expert by the use of algorithms that can capture domain-specific knowledge. Through an extensive survey of research about ship-design expert systems, we conclude that although development and implementation of expert systems for ship design offer substantial barriers, the shipbuilding industry needs them nonetheless. We examine the major reasons that use of expert systems in this industry has lagged behind. These include the problems of integration with existing computer-aided design systems, problems of knowledge representation and sizable development costs. We discuss in detail some key factors that can lead to the solution of these problems. 相似文献
4.
高水头船闸输水廊道反弧门水弹性振动试验研究 总被引:2,自引:1,他引:1
本文简要介绍水弹性振动模型试验的相似准则,用近似满足水弹性相似准则的有机玻璃模型对-高水头船闸反弧形阀门进行流激振动试验研究.试验表明阀门的振动是随机振动,不仅有质量振动而且有结构振动,有若干阶模态被激发参与振动。在开门和关门过程中,阀门面板脉动压力和阀门振动是不大的,与葛洲坝船闸类似阀门间歇开启的振动水平相当。由于常压模型不能正确模拟空化现象,对于廊道内可能产生的空泡溃灭所引起的阀门振动尚需通过减压模型进行研究。 相似文献
5.
简述了LF15和LF16两种新型船用耐蚀可焊铝合金及其配套焊接材料在实船建造中的应用情况。阐述了铝合金全焊结构船体建造的关键技术及我国铝船体建造的3种方法 相似文献
6.
M P Vaquero M Veldhuizen W van Dokkum C J A van den Hamer G Schaafsma 《Journal of the science of food and agriculture》1994,64(4):475-481
The influence of drinking tea on copper bioavailability is unclear, particularly when tea is consumed with food. A breakfast meal containing white bread, margarine, strawberry jam, cheese and tea, with or without milk, was digested in; vitro and the dialysis of copper investigated. Reference breakfasts were prepared with water and water with milk. Copper dialysability (percentage of copper dialysed) was markedly increased by tea. The influence of adding milk to tea was not significant. A second study was carried out in rats using the breakfasts containing tea and water. They were spiked with 64Cu and given orally to the animals in a single dose. Whole-body 64Cu retention was measured over a 4-day period after administration. In order to determine the true absorption of 64Cu a control group of rats received the dose intraperitioneally. The results in vivo indicate a tendency to higher absorption and retention of 64Cu with tea. Liver 64Cu retention was significantly elevated by tea. Therefore, the presence of tea in a breakfast meal favours the formation of soluble low-molecular-weight ligands which can be absorbed and retained by rats. The concomitant increase in liver copper retetition may be associated with higher bioavailability and/or lower copper mobilisation. 相似文献
7.
三峡永久船闸结构缝渗漏处理技术 总被引:1,自引:0,他引:1
在三峡永久船闸结构缝处理过程中,认真分析了结构缝渗漏的原因,通过止水检查槽进行压水检查,确定了渗漏部位。结合渗漏具体情况,采取了结构缝表面嵌填止水材料和廊道周边止水检查槽灌浆相结合的处理方法。在实施过程中,采用了多种新材料和新工艺,取得了良好的效果。 相似文献
8.
Objective To study on the role of thymus transplantation for heart allograft in rats. Methods Vascularized heart-thymus combined transplantation was performed with microsurgical technique. Graft survival, histopathology,
level of IL-2, IL-4 and its mRNA expression in serum and cardiac grafts were investigated. Results Heart-thymus combined transplantation achieved effect in the prolongation of cardiac graft survival with short-term administration
of cyclosporine. Conclusions Vascularized thymus transplantation induced immune tolerance in thymectomized rats. 相似文献
9.
Lipid-Lowering Effect of Eriocitrin, the Main Flavonoid in Lemon Fruit, in Rats on a High-Fat and High-Cholesterol Diet 总被引:2,自引:0,他引:2
Yoshiaki Miyake Eriko Suzuki Satoko Ohya Syuichi Fukumoto Masanori Hiramitsu Kazuhiro Sakaida Toshihiko Osawa Yukio Furuichi 《Journal of food science》2006,71(9):S633-S637
ABSTRACT: Eriocitrin (eriodictyol 7- O -β-rutinoside) is the main flavonoid in lemon fruit. In this study, eriocitrin was investigated for its lowering effect on serum and hepatic lipids in high-fat and high-cholesterol fed rats. Rats in the control group ( N = 6) were fed a 20% lard and 1% cholesterol diet for 21 d, and rats in the 0.35% eriocitrin group ( N = 6) and 0.70% eriocitrin group ( N = 6) were fed a diet supplemented with eriocitrin 0.35% and 0.70%, respectively. The content of hepatic total cholesterol and triglyceride in the eriocitrin group was no different from that of the control group. The total cholesterol, VLDL+LDL, triglyceride, and phospholipid in the serum of the 0.35% eriocitrin group showed significantly lower concentrations than the control group ( P < 0.05), although there was no difference in the HDL concentrations among the groups. The lowering effect of eriocitrin for serum total cholesterol was thought to be caused by a decrease in VLDL+LDL. The 0.35% eriocitrin group was shown to have a significant increase in excretion of fecal bile acid ( P < 0.05) and a tendency for enhanced hepatic m-RNA levels of LDL receptor in comparison with the control group. 相似文献
10.