Multifaceted Mechanisms of Action of Metformin Which Have Been Unraveled One after Another in the Long History

While there are various kinds of drugs for type 2 diabetes mellitus at present, in this review article, we focus on metformin which is an insulin sensitizer and is often used as a first-choice drug worldwide. Metformin mainly activates adenosine monophosphate-activated protein kinase (AMPK) in the liver which leads to suppression of fatty acid synthesis and gluconeogenesis. Metformin activates AMPK in skeletal muscle as well, which increases translocation of glucose transporter 4 to the cell membrane and thereby increases glucose uptake. Further, metformin suppresses glucagon signaling in the liver by suppressing adenylate cyclase which leads to suppression of gluconeogenesis. In addition, metformin reduces autophagy failure observed in pancreatic β-cells under diabetic conditions. Furthermore, it is known that metformin alters the gut microbiome and facilitates the transport of glucose from the circulation into excrement. It is also known that metformin reduces food intake and lowers body weight by increasing circulating levels of the peptide hormone growth/differentiation factor 15 (GDF15). Furthermore, much attention has been drawn to the fact that the frequency of various cancers is lower in subjects taking metformin. Metformin suppresses the mechanistic target of rapamycin (mTOR) by activating AMPK in pre-neoplastic cells, which leads to suppression of cell growth and an increase in apoptosis in pre-neoplastic cells. It has been shown recently that metformin consumption potentially influences the mortality in patients with type 2 diabetes mellitus and coronavirus infectious disease (COVID-19). Taken together, metformin is an old drug, but multifaceted mechanisms of action of metformin have been unraveled one after another in its long history.     

WCDMA系统接口信令消息的描述与实现

WCDMA作为第三代移动通信系统的主流标准，能够提供多种类型的多媒体服务。为了实现各种用户平面数据的传输，系统会提前通过控制平面对所需的无线资源进行分配。由于配置过程是通过接口之间发送控制平面应用协议消息来实现的，因此能否正确有效地对信令消息进行编解码成为保证系统稳定工作的关键因素。3GPP标准中，ASN．1语言被用来描述接口信令消息。首先简要介绍了WCDMA系统结构以及主要接口协议，重点描述了ASN．1存在的意义及其编解码规则，最后给出了基于ASN．1的开发环境下应用层网络协议的开发流程。     

2Mbit/s高速信令链路在移动通信七号信令网中的应用

通过对2Mbit/s高速信令链路原理、特点的介绍，阐明了该技术在现阶段使用的实际意义，并给出了2Mbit/s高速信令链路在移动通信七号信令网中的应用。     

自动交换光网络的信令控制方式研究

自动交换光网络是一种能够自动完成网络连接的新型网络。他由控制面、传送面和管理面3个平面组成，控制面技术是其核心，利用控制面能够实施动态交换。本文在研究分析已有的光网络信令控制方式的基础上，提出了一种混合信令控制方式，他具有更好的性能和信令控制能力，适合ASON的信令网和控制面要求。     

下一代网络--多协议标记交换MPLS思想剖析

多协议标记交换MPLS通过在传统的IP包里加入标记，使原来依赖于IP头标分析的路由转发转变为依赖于标记的转发，这不仅可以大大地提高IP包的转发速度，更可使传统IP网络具有QoS能力。本文深入分析了标记转发的思想．并指出了MPLS实现其优点所用的机制与原理。     

铁路信号电缆断线故障在线监测与定位方法研究

铁路信号电缆是保证列车安全运营的重要组成部分,其故障严重影响列车的安全运营;由于其经多个分线盒接线柱连接的敷设特点,存在中间接头过多,致使传统的电缆故障检测方法应用受到了极大的限制;为此,通过在电缆中间分线盒的备用芯线对接线柱中接入固定阻值的电阻,将备用芯线对形成闭合回路网络,然后在线监测其电阻阻值,利用回路阻值的变化来反映电缆状态,并以在线监测备用芯线对代替在用芯线对,进而在不影响正常列控信号传输的情况下实现了信号电缆的故障在线监测;经实际测试,有效地解决了铁路信号电缆断线故障的在线监测及定位。