Influence of geosynthetic reinforcement on the stability of an embankment with rigid columns embedded in an inclined underlying stratum

Incompressible dipping substrata are commonly encountered in engineering practice. Compared to horizontal underlying strata, the inclined underlying stratum increase the risk of collapse of embankments reinforced with columns because it weakens the restraint of the column base. The objective of this study is to investigate the effectiveness of geosynthetics on improving the embankment stability when the underlying stratum is inclined. The influence of geosynthetic tensile stiffness on the ultimate surcharge and failure mechanism is studied. A deep-seated failure with column tilting occurs when the geosynthetic tensile stiffness is low, whereas a lateral sliding occurs when the geosynthetic tensile stiffness is high. To illustrate the contribution of geosynthetics, the distribution of the lateral pressures acting on the columns is analyzed.     

The Critical Role of Passive Permeability in Designing Successful Drugs

Passive permeability is a key property in drug disposition and delivery. It is critical for gastrointestinal absorption, brain penetration, renal reabsorption, defining clearance mechanisms and drug-drug interactions. Passive diffusion rate is translatable across tissues and animal species, while the extent of absorption is dependent on drug properties, as well as in vivo physiology/pathophysiology. Design principles have been developed to guide medicinal chemistry to enhance absorption, which combine the balance of aqueous solubility, permeability and the sometimes unfavorable compound characteristic demanded by the target. Permeability assays have been implemented that enable rapid development of structure-permeability relationships for absorption improvement. Future advances in assay development to reduce nonspecific binding and improve mass balance will enable more accurately measurement of passive permeability. Design principles that integrate potency, selectivity, passive permeability and other ADMET properties facilitate rapid advancement of successful drug candidates to patients.     

野外大气扩散试验中四面体气球示踪实验的初步评价

1985年11月在瑞士北部进行了一次以探讨“冷池”条件下的扩散和湍流特征为目的的国际野外大气试验,本文介绍其中的四面体气球示踪实验的结果。一共进行了三次由雷达跟踪的四面体示踪实验,释放了10个四面体球。按多轨迹法和单轨迹法分别估算并比较了其中两次示踪实验得到的水平扩散参数σ_y,探讨了风摆效应的贡献。采用“体源模式”并结合单轨迹法估算了微弱风场不定风向条件下的扩散参数,分析了静风,弱风条件下的水平风向标准差和湍流强度。     

机动武器系统的含间隙动力学研究--下篇:系统仿真

本文把中篇建立的间隙铰模型引入多体系统动力学分析中,得到了一种处理含间隙多体系统动力学问题的一般方法.应用这种方法对机动武器的发射过程进行了原理性的仿真,验证了前面建立的碰撞模型和间隙模型,并分析了间隙对导弹运动状态的影响.导弹发射过程具有变拓扑的特点,本文方法提供了一种处理这类问题的思路.     

A framework of virtual prototyping environment for the design and analysis of mechanical mechanism with clearance

Mechanical mechanisms with clearance abound in technological fields such as robotics, machine and steam turbine industry. The dynamic performance of these mechanisms in working condition can be achieved provided that the effects of the different on the mechanisms (such as mechanism dynamics, technological effects and thermal behaviour) are thoroughly understood. Virtual prototyping provides an integration of multi-domain dynamic simulation for the design and analysis process. In the current paper, a framework of virtual prototyping environment for the design and analysis of mechanical mechanism with clearance is presented. A case study with such a simulation strategy is studied for the optimum design and analysis of the technological parameter.     

论剪切质量的提高

通过对飞剪剪切长度，精度，剪刃间隙和压板机构等参数的优化，来提高钢板的剪切质量。     

晶体管的计算机辅助设计

将晶体管设计中繁琐的纵向、横向参数的设计计算以及参数验算,采用Basic人机对话方式,由计算机完成。并用BAsic语言绘制出所需的七块光刻掩膜图。既大大地减轻了设计人员繁琐劳动、缩短了设计时间、提高设计质量,又便于修改。还可广泛用于同种结构的不同动率要求的各种晶体管的设计中。     

Pile Response Adjacent to Braced Excavation

The excavation of soil for the construction of basements or cut-and-cover tunnels results in ground movements. One particular concern is that the excavation-induced lateral soil movements may adversely affect any nearby pile foundation. The lateral loads imposed by the soil movements induce bending moments and deflections in the pile, which may lead to structural distress and failure. This paper presents the results of an actual full-scale instrumented study that was carried to examine the behavior of an existing pile due to nearby excavation activities resulting from the construction of a 16 m deep cut-and-cover tunnel. The pile was located 3 m behind a 0.8 m thick diaphragm wall. Excavation to the formation level that was 16 m below the ground surface resulted in a maximum lateral pile movement of 28 mm. A simplified numerical procedure based on the finite-element method was used to analyze the pile response. Generally, the theoretical predictions were in reasonable agreement with the measured results.     

排气系统在注射模中的应用

介绍了排气系统在注射模中的重要性,排气系统位置的选择,排气系统的种类以及应用等     

NUMERICAL SIMULATION OF TIP-CLEARANCE FLOW IN CASCADE

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