The generalized discrete ‐centroid problem

The ‐centroid problem or leader–follower problem is generalized considering different customer choice rules where a customer may use facilities belonging to different firms, if the difference in travel distance (or time) is small enough. Assuming essential goods, some particular customer choice rules are analyzed. Linear programming formulations for the generalized ‐medianoid and ‐centroid problems are presented and an exact solution approach is applied. Some computational examples are included.     

2-Phenyloxazole-4-carboxamide as a Scaffold for Selective Inhibition of Human Monoamine Oxidase B

A series of 2-phenyloxazoles bearing an amide group at position 4 were designed and synthesized for evaluation as potential inhibitors of human recombinant monoamine oxidases (hrMAOs). Results of kinetics experiments demonstrated that all compounds behave as competitive MAO inhibitors, with good selectivity toward the MAO-B isoform. The most potent and selective derivatives are characterized by inhibition constant (K_i) values in the sub-micromolar range and a good selectivity index (K_{i MAO-A}/K_{i MAO-B}>50). Some derivatives were also found to be able to inhibit MAO activity in nerve growth factor (NGF)-differentiated PC12 cells, taken as a model of neuronal cells. In particular, 2-(2-hydroxyphenyl)-N-phenyloxazole-4-carboxamide (compound 4 a ) may be a promising new scaffold, exerting the highest selectivity and inhibitory effect toward MAOs in NGF-differentiated PC12 cell lysates, without compromising cell viability. Molecular docking analysis allowed a rationalization of the experimentally observed binding affinity and selectivity.     

制造业企业竞争情报系统建设浅析

讨论了制造业企业信息化进程中包含竞争情报系统的必要性。论述了该类企业竞争情报系统的内涵及功能特征。较详细地介绍了相应系统常用外部数据资源内容及各自应用特点;此外本文还简要地说明了该类系统现有开发支持工具软件、开发关键步骤等内容。     

神经网络在缺陷识别中的应用

为了准确、快速地进行缺陷识别，介绍了一种新型的前馈神经网络模型，即径向基概率神经网络。与以往的算法相比，该方法具有分类识别精度高且速度快的优点。仿真获得了很好的结果。     

浙江省铜加工产业国际竞争力因素分析、应对思路

文章从提高铜加工产业国际竞争力角度,比较宏观地分析了浙江省铜加工产业国际竞争力提高的环境、积极与消极因素,针对性地提出了提升浙江省铜加工产业国际竞争力的应对思路。     

某半导体产品的设计和快速实现研究

研究了产品开发及快速实现过程中任务获取、任务分配、进度的协调、信息传输等相关问题,并以某半导体产品为例,进行了产品的设计和快速实现,为缩短产品开发和上市周期、提高产品的市场竞争力积累经验。     

试论入世对中国氧化铝工业的影响

随着中国加入WTO，给企业带来了发展的机会，也带来了挑战。本文通过对中国氧化铝工业的现状及其与世界水平的差距的分析，阐明了入世后随着关税等贸易壁垒的消除，国内、国际市场的竞争更加激烈。明确指出了我国氧化铝工业面临的多重挑战，以及给中国氧化铝工业带来的机遇。强调充分利用WTO给企业创设的权利，借入世东风，促进我国氧化铝工业快速发展，只有发展，中国氧化铝工业才有出路。     

A study on the critical success factors for corporations embarking on knowledge community-based e-learning

Corporations have felt the pressure for fast-paced innovations and knowledge transfer as major driving forces in raising their sustainable competitive advantage and organizational total productivity. Thus, the development of the knowledge community through e-learning is an important strategy in implementing knowledge management policy. This paper illustrates an empirical study with which to conduct qualitative research of learning organization. From the case company’s real progress and practical experience, some core principles were extracted from four managerial aspects, such as: strategy, technology, process, and personnel. These aspects were analyzed in order to understand the value chain framework and the major concerns of knowledge community development. Further, the main benefits are addressed and certain critical factors are proposed and shown in this paper to ensure the success of corporations embarking on knowledge community-based e-learning.     

论企业竞争情报信息系统的构建与重要性

简要地述叙了现代企业构建竞争情报信息系统的必要性,介绍了竞争情报信息的构建与应用以及该系统在企业中所起的重要作用。     

零部件通用对企业竞争战略的影响

零部件通用是目前研究的一个热点问题,但是绝大多数文章都是针对零部件通用对库存水平的影响。本文从战略的角度,分析了零部件通用对企业竞争战略的影响,发现它不仅对降低费用有着积极的影响,而且对缩短新产品开发周期、制造过程重组等方面也有着积极的作用。因此,零部件的通用性已经从战术上的节约费用上升为战略上的竞争武器。