Liner services network design and fleet deployment with empty container repositioning

Transportation demand of shipping container fluctuates due to the seasonality of international trade, thus, every 3–6 months, the liner company has to alter its current liner shipping service network, redeploy ships and design cargo routes with the objective of minimizing the total cost. To solve the problem, the paper presents a mixed integer linear program model. The proposed model incorporates several relevant constraints, such as weekly frequency, the transshipment of cargo between two or more service routes, and transport time. Extensive numerical experiments based on realistic date of Asia–Europe–Oceania shipping operations show that the proposed model can solve real-case problems efficiently by CPLEX. The results demonstrate that the model can reduce ship’s capacity consumption and raise ships’ capacity utilization.     

嵌入式实时操作系统内核混合代码的自动化验证框架

"如何构造高可信的软件系统"已成为学术界和工业界的研究热点.操作系统内核作为软件系统的基础组件，它的安全可靠是构造高可信软件系统的重要环节.为了确保操作系统内核的安全可靠，将形式化方法引入到操作系统内核验证中，提出了一个自动化验证操作系统内核的框架.该验证框架包括：（1）分别对C语言程序和混合语言程序（C语言和汇编语言）进行验证；（2）在混合语言程序验证中，为汇编程序建立抽象模型，并将C语言程序和抽象模型粘合形成基于C语言验证工具可接收的验证模型；（3）从规范中提取性质，基于该自动验证工具，对性质完成自动验证；（4）该框架不限于特定的硬件架构.成功地运用该验证框架对两种不同硬件平台的嵌入式实时操作系统内核μC/OS-II进行了验证.结果显示：利用该框架在对两个不同的硬件平台上内核验证时，框架的可重复利用率很高，高达到88%，虽然其抽象模型需要根据不同的硬件平台进行重构.在对基于这两种平台的操作系统内核验证中，分别发现了10~12处缺陷.其中，在ARM平台上两处与硬件相关的问题被发现.实验表明，该方法对不同硬件平台的同一个操作系统分析验证具有一定的通用性.     

Identification of Host Cellular Protein Substrates of SARS-COV-2 Main Protease

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease-19 (COVID-19) being associated with severe pneumonia. Like with other viruses, the interaction of SARS-CoV-2 with host cell proteins is necessary for successful replication, and cleavage of cellular targets by the viral protease also may contribute to the pathogenesis, but knowledge about the human proteins that are processed by the main protease (3CLpro) of SARS-CoV-2 is still limited. We tested the prediction potentials of two different in silico methods for the identification of SARS-CoV-2 3CLpro cleavage sites in human proteins. Short stretches of homologous host-pathogen protein sequences (SSHHPS) that are present in SARS-CoV-2 polyprotein and human proteins were identified using BLAST analysis, and the NetCorona 1.0 webserver was used to successfully predict cleavage sites, although this method was primarily developed for SARS-CoV. Human C-terminal-binding protein 1 (CTBP1) was found to be cleaved in vitro by SARS-CoV-2 3CLpro, the existence of the cleavage site was proved experimentally by using a His₆-MBP-mEYFP recombinant substrate containing the predicted target sequence. Our results highlight both potentials and limitations of the tested algorithms. The identification of candidate host substrates of 3CLpro may help better develop an understanding of the molecular mechanisms behind the replication and pathogenesis of SARS-CoV-2.     

dU/dt引发的MOSFET误导通分析

分析了MOSFET误导通产生的原因,分别从原理和理论推导两个方面作了分析,主要考虑了开关管中寄生参数对开关特性的影响。通过求解误导通发生的条件,得到哪些参数会导致误触发,最后给出了仿真。文中还提出如何避免MOSFET误导通产生,以及改进方法,对减少实际应用中MOSFET破坏性损坏有一定意义。     

CMOS光接收机主放大器设计

利用CMOS工艺设计一种用于SDH STM 4速率级(622 Mb/s)光纤用户网的光接收机放大电路。此电路由输入/输出缓冲、主放大单元、偏置补偿电路4部分组成。通过直接耦合技术提高增益,降低功耗;利用有源电感负载提高系统带宽。采用商用SmartSpice电路仿真软件和CSMC HJ 0.6μm工艺参数对该电路进行仿真。结果表明,该电路在5 V工作电压下中频增益为81 dB,3 dB带宽为470 MHz。     

万家寨引黄工程北干1号隧洞Ⅳ标155-274型TBM主轴承总成组装概要

文中对万家寨引黄工程北干线1号隧洞Ⅳ标使用的155—274型TBM主轴承总成各部件组装过程及其相应的技术要求进行了概要的描述，目的是进一步熟悉155—274型TBM主轴承总成的各个部件并加深对主轴承工作原理的理解。     

浅谈如何有效学习计算机软件知识

计算机软件知识的学习并不是完全线性的，而是不断循环往复、迭代的过程。本对如何深入、广泛、有效地学习计算机软件知识做出了一些探讨。     

西部地区深井井身结构设计技术探讨

科学合理地确定井身结构及钻井液密度是深井超深井钻井的关键环节之一，其基础是准确建立地层孔隙压力、地应力、破裂压力、坍塌压力的钻前预测剖面。分析了西部地区目前深井井身结构的缺点和进行井身结构应考虑的问题，介绍了深探井井身结构的设计方法，并针对西部复杂地区的地层特点，建议采用3种增加技术套管的井身结构方案。塔河油田钻井实践表明，采用这3种井身结构方案后，深井机械钻速得到提高，钻井周期缩短，而且降低了钻井成本。     

A three-dimensional FE analysis of large deformations for impact loadings using tetrahedral elements

 A three-dimensional dynamic program for the anaysis of large deformations in contact-penetration problems is developed using the finite element Lagrangian method with explicit time integration. By incorporating a tetrahedral element, which allows a single-point integration without a special hourglass control scheme, this program can be more effective to the present problem. The position code algorithm is used to search contact surface. Eroding surfaces are also considered. The defense node algorithm was slightly modified for the calculation of contact forces. A study of obliquity effects on metallic plate perforation and ricochet processes in thin plates impacted by a sphere was conducted. It is well simulated that on separation of two parts of the sphere, the portion still within the crater tends to perforate, while the portion in contact with the plate surface ricochets. This deformation pattern is observed in experiments, especially at high obliquities. A long rod that impacts an oblique steel plate at high impact velocity was also simulated in order to study the dynamics of the rod caused by the three dimensional asymmetric contact. The agreement between simulated and experimental results is quite good. Fracture phenomena occuring at high obliquity deserves further investigations. Received: 20 February 2002 / Accepted: 20 September 2002     

车古201潜山油藏完井方式研究

研究了国内外潜山油藏完井方式应用及其使用条件、井身结构的应用 ,针对车古 2 0 1油藏特点 ,论证了其对裸眼完井、筛管完井、尾管射孔完井、管外封隔器完井的适应性 ,通过对比研究 ,从更好地满足油藏工程、采油工艺、增产措施出发 ,选择出车古 2 0 1潜山油藏最合理的完井方式为尾管注水泥射孔完井 ,并给出了应采用的井身结构