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1.
Resistance to chemotherapy still remains a major challenge in the clinic, impairing the quality of life and survival rate of patients. The identification of unconventional chemosensitizing agents is therefore an interesting aspect of cancer research. Resveratrol has emerged in the last decades as a fascinating molecule, able to modulate several cancer-related molecular mechanisms, suggesting a possible application as an adjuvant in cancer management. This review goes deep into the existing literature concerning the possible chemosensitizing effect of resveratrol associated with the most conventional chemotherapeutic drugs. Despite the promising effects observed in different cancer types in in vitro studies, the clinical translation still presents strong limitations due to the low bioavailability of resveratrol. Recently, efforts have been moved in the field of drug delivery to identifying possible strategies/formulations useful for a more effective administration. Despite the necessity of a huge implementation in this research area, resveratrol appears as a promising molecule able to sensitize resistant tumors to drugs, suggesting its potential use in therapy-refractory cancer patients.  相似文献   
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通过借鉴中医学整体观和生命观的相关理论,从认识城市有机体的生命属性入手,发现并提炼能够产生和传递城市运营所需各种能量的生命要素:廊道和功能体。阐释了其多层级、多性质和多形态的特点,提出了功能体有动力、廊道成系统、敏感点有活力的疏通策略,旨在促进城市各种能量的有机循环,从而维护城市的健康与安全,提高城市生活的效率与质量。  相似文献   
4.
The correct separation of chromosomes during mitosis is necessary to prevent genetic instability and aneuploidy, which are responsible for cancer and other diseases, and it depends on proper centrosome duplication. In a recent study, we found that Smy2 can suppress the essential role of Mps2 in the insertion of yeast centrosome into the nuclear membrane by interacting with Eap1, Scp160, and Asc1 and designated this network as SESA (S my2, E ap1, S cp160, A sc1). Detailed analysis showed that the SESA network is part of a mechanism which regulates translation of POM34 mRNA. Thus, SESA is a system that suppresses spindle pole body duplication defects by repressing the translation of POM34 mRNA. In this study, we performed a genome-wide screening in order to identify new members of the SESA network and confirmed Dhh1 as a putative member. Dhh1 is a cytoplasmic DEAD-box helicase known to regulate translation. Therefore, we hypothesized that Dhh1 is responsible for the highly selective inhibition of POM34 mRNA by SESA.  相似文献   
5.
D. P. Phillips, T. E. Ruth, and L. M. Wagner (1993) reported that 1969-1990 California mortality data show that Chinese Americans are particularly vulnerable to diseases that Chinese astrology and traditional Chinese medicine associate with their birth years. For example, because fire is associated with the heart, a Chinese person born in a fire year (such as 1937) is more likely to die of heart disease than is a Chinese person born in a nonfire year. However, many diseases were excluded from this study, some diseases that were included have ambiguous links to birth years, and the statistical tests were indirect. A more complete statistical analysis and independent California mortality data for the years 1960-1968 and 1991-2002 did not replicate the original results. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   
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Psychoanalytic psychotherapy is threatened by two underlying social and economic developments. One is pressures of the marketplace that are altering all traditional professional relationships, threatening to undermine our familiar relationship with clients. The second is changes in the medical profession that call into question the appropriateness and utility of our long-standing link with medicine. The problems are explored and some suggestions put forth. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   
7.
光调节的叶绿体mRNA的翻译需要mRNA5′,非翻译区(5′ UTR)相互作用的中间作用因子.叶绿体多聚腺苷酸结合蛋白(cPABP)RB47特异性地与PsbAmRNA的5′ UTR结合,并对于该mRNA的翻译是很重要的.定位于叶绿体中与cPABP伴随纯化出来的一种蛋白质二硫化物异钩酶RB60表现出调节cPABP与PsbAmRNA的5′ UTR结合的特性.这种调节是通过可逆地改变有氧化还原特征的cPABP的氧化还原状态来实现,或通过ADP依赖的磷酸化来实现.这种机制就在调节叶绿体的基因表达中提供了一个简单可逆的开关机制.  相似文献   
8.
激光技术在医学应用的若干进展   总被引:2,自引:0,他引:2       下载免费PDF全文
钱焕文  单清 《激光技术》1994,18(5):317-320
本文评介激光医学机理、应用和进展,以及发展方向。  相似文献   
9.
王方 《包装工程》1992,(6):285-287
中药大蜜丸及所用包装材料软、粘、轻、小、光,较难实现机械化自动包装。通常的监控方法不适合蜜丸的自动包装。采用红外线光电控制器,解决了自动包装蜜丸时出现的瞬间无纸、无丸等自动控制。  相似文献   
10.
Scheduling emergency medicine residents (EMRs) is a complex task, which considers a large number of rules (often conflicting) related to various aspects such as limits on the number of consecutive work hours, number of day and night shifts that should be worked by each resident, resident staffing requirements according to seniority levels for the day and night shifts, restrictions on the number of consecutive day and night shifts assigned, vacation periods, weekend off requests, and fair distribution of responsibilities among the residents. Emergency rooms (ERs) are stressful workplaces, and in addition shift work is well-known to be more demanding than regular daytime work. For this reason, preparing schedules that suit the working rules for EMRs is especially important for reducing the negative impact on shift workers physiologically, psychologically, and socially. In this paper, we present a goal programming (GP) model that accommodates both hard and soft constraints for a monthly planning horizon. The hard constraints should be adhered to strictly, whereas the soft constraints can be violated when necessary. The relative importance values of the soft constraints have been computed by the analytical hierarchy process (AHP), which are used as coefficients of the deviations from the soft constraints in the objective function. The model has been tested in the ER of a major local university hospital. The main conclusions of the study are that problems of realistic size can be solved quickly and the generated schedules have very high qualities compared to the manually prepared schedules, which require a lot of effort and time from the chief resident who is responsible for this duty.  相似文献   
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