高均匀性长波红外远心照明系统设计

基于数字微镜器件(DMD)的红外景象模拟器可在室内环境下模拟真实景物及其环境的红外辐射,实现对红外成像系统性能的准确测试与评估。照明系统作为红外景象模拟器的重要组成部分,为其提供红外辐射能。为使光束均匀照射在DMD器件表面,通过分析研究黑体特性及朗伯定律,确定采用像方远心光路作为照明系统的结构形式。以拉氏不变量为依据研究确定的照明系统特性参数,能够实现与投影系统完美衔接。根据设计参数完成对照明系统初始结构的计算,利用ZEMAX进行调制、优化,并完成像质评价。设计结果表明,以此方式设计的照明系统均匀性高、球差小,可进一步提高模拟仿真效果。     

基于DMD的红外目标模拟器光学系统的设计

介绍了DMD的工作原理以及相应的红外景象模拟技术的特点,设计了一种工作在8-12μm波段的红外目标模拟器。对系统整体进行建模、分析,DMD表面照度均匀。投影系统采用四片式结构,焦距405mm。MTF在10lp/mm处大于0.5,弥散斑均方根半径小于衍射极限,系统畸变控制在0.5%以内。该系统结构紧凑,性能良好。     

基于DMD的驱动控制系统设计与实现

以DMD(数字微镜设备)为核心的DLP(数字光处理)投影技术有着巨大的应用潜力.因此,主要从DMD的时序驱动控制、数据产生与复位驱动控制3方面介绍了一种基于DMD的驱动控制系统的设计与实现方案,说明了主功能芯片DDC4100驱动芯片和DAD2000复位芯片的使用及功能,并在实际系统测试中成功地实现了对二值图像的显示.     

CRT替代技术在军用飞机平视显示器中的应用

随着数字显示技术的发展,目前平视显示器中普遍使用的CRT有被取代的趋势.国外早巳开始对,CRT替代技术的探索和研究,并已研制出新型HUD样机.可用于替代CRT产生图像的设备有:数字微镜装置、反射型液晶显示器和透射型液晶显示器等;可选用的光源有激光器、弧光灯、LED和荧光粉.对最有可能用于平显的几种显示技术和光源进行了综合比较,介绍了国外三家公司分别采用LCOS和DMD技术研制的新型平显情况,提出进行平显改进的必要性和思路.     

CRISPR Therapeutics for Duchenne Muscular Dystrophy

Duchenne muscular dystrophy (DMD) is an X-linked recessive neuromuscular disorder with a prevalence of approximately 1 in 3500–5000 males. DMD manifests as childhood-onset muscle degeneration, followed by loss of ambulation, cardiomyopathy, and death in early adulthood due to a lack of functional dystrophin protein. Out-of-frame mutations in the dystrophin gene are the most common underlying cause of DMD. Gene editing via the clustered regularly interspaced short palindromic repeats (CRISPR) system is a promising therapeutic for DMD, as it can permanently correct DMD mutations and thus restore the reading frame, allowing for the production of functional dystrophin. The specific mechanism of gene editing can vary based on a variety of factors such as the number of cuts generated by CRISPR, the presence of an exogenous DNA template, or the current cell cycle stage. CRISPR-mediated gene editing for DMD has been tested both in vitro and in vivo, with many of these studies discussed herein. Additionally, novel modifications to the CRISPR system such as base or prime editors allow for more precise gene editing. Despite recent advances, limitations remain including delivery efficiency, off-target mutagenesis, and long-term maintenance of dystrophin. Further studies focusing on safety and accuracy of the CRISPR system are necessary prior to clinical translation.     

DMD红外场景产生器非均匀性校正方法研究

非均匀性是影响数字微镜器件(Digital Micro-mirror Device,DMD)红外场景产生器投射红外场景质量的主要因素之一,DMD红外场景产生器必须经过非均匀性校正才能满足复杂环境下红外成像设备内场仿真试验的应用要求.给出了DMD红外场景产生器的非均匀性校正流程;提出了一种更适合于现有测试条件的变尺度稀疏...     

基于DMD成像系统的红外小目标仿真

在分析红外成像仿真系统研究现状的基础上,研究了典型红外小目标的模型和移 动式滤波跟踪算法。依据飞行器内部构造及工艺材料,并结合空气动力学、物理学以及热辐射的相关理论, 从蒙皮辐射、尾喷焰等方面建立了飞行器的红外辐射模型。针对数字微镜阵列(Digital Mirror Device, DMD) 系统的特点,对模型进行了简化,提高了图像生成速度。最后利用基于数字微镜阵列的成像仿真系统平台 对模型和算法进行了实验验证。实验结果表明,该方法具有图像清晰、信噪比高、生成速度快、管道存储时间小以及 跟踪稳定等特点。     

DMD全息系统重构灰度级分数傅立叶全息图

论文提出一种基于DMD投影系统的全息重构系统,用VC++实现分数傅立叶变换全息图生成平台并生成灰度全息图,由DMD全息系统实现灰度级分数傅立叶变换全息图重构,验证了DMD全息系统的可行性。此系统可为动态全息显示提供硬件基础。     

Non-Coding RNAs in Muscle Dystrophies

ncRNAs are the most recently identified class of regulatory RNAs with vital functions in gene expression regulation and cell development. Among the variety of roles they play, their involvement in human diseases has opened new avenues of research towards the discovery and development of novel therapeutic approaches. Important data come from the field of hereditary muscle dystrophies, like Duchenne muscle dystrophy and Myotonic dystrophies, rare diseases affecting 1 in 7000–15,000 newborns and is characterized by severe to mild muscle weakness associated with cardiac involvement. Novel therapeutic approaches are now ongoing for these diseases, also based on splicing modulation. In this review we provide an overview about ncRNAs and their behavior in muscular dystrophy and explore their links with diagnosis, prognosis and treatments, highlighting the role of regulatory RNAs in these pathologies.