Mitochondrial Bioenergetic,Photobiomodulation and Trigeminal Branches Nerve Damage,What’s the Connection? A Review

Background: Injury of the trigeminal nerve in oral and maxillofacial surgery can occur. Schwann cell mitochondria are regulators in the development, maintenance and regeneration of peripheral nerve axons. Evidence shows that after the nerve injury, mitochondrial bioenergetic dysfunction occurs and is associated with pain, neuropathy and nerve regeneration deficit. A challenge for research is to individuate new therapies able to normalise mitochondrial and energetic metabolism to aid nerve recovery after damage. Photobiomodulation therapy can be an interesting candidate, because it is a technique involving cell manipulation through the photonic energy of a non-ionising light source (visible and NIR light), which produces a nonthermal therapeutic effect on the stressed tissue. Methods: The review was based on the following questions: (1) Can photo-biomodulation by red and NIR light affect mitochondrial bioenergetics? (2) Can photobiomodulation support damage to the trigeminal nerve branches? (preclinical and clinical studies), and, if yes, (3) What is the best photobiomodulatory therapy for the recovery of the trigeminal nerve branches? The papers were searched using the PubMed, Scopus and Cochrane databases. This review followed the ARRIVE-2.0, PRISMA and Cochrane RoB-2 guidelines. Results and conclusions: The reliability of photobiomodulatory event strongly bases on biological and physical-chemical evidence. Its principal player is the mitochondrion, whether its cytochromes are directly involved as a photoacceptor or indirectly through a vibrational and energetic variation of bound water: water as the photoacceptor. The 808-nm and 100 J/cm² (0.07 W; 2.5 W/cm²; pulsed 50 Hz; 27 J per point; 80 s) on rats and 800-nm and 0.2 W/cm² (0.2 W; 12 J/cm²; 12 J per point; 60 s, CW) on humans resulted as trustworthy therapies, which could be supported by extensive studies.     

Cross lingual speech emotion recognition via triple attentive asymmetric convolutional neural network

The application of cross‐corpus for speech emotion recognition (SER) via domain adaptation methods have gain high acknowledgment for developing good robust emotion recognition systems using different corpora or datasets. However, the issue of cross‐lingual still remains a challenge in SER and needs more attention to resolve the scenario of applying different language types in both training and testing. In this paper, we propose a triple attentive asymmetric convolutional neural network to address the recognition of emotions for cross‐lingual and cross‐corpus speech in an unsupervised approach. The proposed method adopts the joint supervision of softmax loss and center loss to learn high power discriminative feature representations for target domain via the use of high quality pseudo‐labels. The proposed model uses three attentive convolutional neural networks asymmetrically, where two of the networks are used to artificially label unlabeled target samples as a result of their predictions from training on source labeled samples and the other network is used to obtain salient target discriminative features from the pseudo‐labeled target samples. We evaluate our proposed method on three different language types (i.e., English, German, and Italian) data sets. The experimental results indicate that, our proposed method achieves higher prediction accuracy over other state‐of‐the‐art methods.     

多特征的中文文本校对算法的研究

本文阐述了中文文本信息的特征,并在此基础上提出了利用文本信息的统计特征规律和评议结构特征规律进行中文文本校对的方法及其实现的算法。     

一种实现控件与多语言文本动态绑定的方法

现代应用中大多已有进行多语言切换的需求,但对于控件本身文本显示信息,要实现多语言实时切换还有一些难度,文中提出一种能够根据用户的选择将控件与显示文本进行动态绑定显示的方法,通过对控件文本信息的多语言实时切换.该方法具有执行效率较高、定制选择灵活方便、性能稳定可靠、适用范围较为广泛的特点.该方法已在基于CAR构件的Elastos操作系统上实现并运用于智能手机应用.     

Functional and comparative study of lingual papillae in four species of bear (Ursidae) by scanning electron microscopy

The eight current species of bear (Ursidae) are widely distributed throughout Europe, Asia, and America. They are mainly encountered in the northern hemisphere, except for the spectacled bear and the sun bear, which are also found in the south of the equator. Adaptations of the masticatory apparatus (teeth, tongue, and musculature) to diet are one of the factors that imply the greatest structural changes in the cranium. This diet may be carnivorous, herbivorous, melliferous, or insectivorous, with one type of food predominating according to the time of year. The way in which food is eaten determines the morphology of the lingual surface; generally speaking, all bears put their mouth to the food, which, initially, they lick or they let the food stick to their tongue, as occurs when insects are eaten. As in all mammals, a distinction can be made between mechanical and gustatory papillae and the development and distribution of which depend on the species and their eating habits. In this study of the complete tongues of four species of adult bears, we describe the morphology of the lingual surfaces, the different types of papillae, their characteristics, and topographic distribution. It was seen that there were five main types of lingual papillae: filiform, conical, fungiform, foliate, and vallate. Morphology of the microgrooves and pores was similar to that observed in other mammals. In general, there were no great differences among the four species of bears studied, perhaps due to the similarity in the kind of food they consume in captivity.     

Lingual Epithelial Stem Cells and Organoid Culture of Them

As tongue cancer is one of the major malignant cancers in the world, understanding the mechanism of maintenance of lingual epithelial tissue, which is known to be the origin of tongue cancer, is unquestionably important. However, the actual stem cells that are responsible for the long-term maintenance of the lingual epithelium have not been identified. Moreover, a simple and convenient culture method for lingual epithelial stem cells has not yet been established. Recently, we have shown that Bmi1-positive cells, residing at the second or third layer of the epithelial cell layer at the base of the interpapillary pit (IPP), were slow-cycling and could supply keratinized epithelial cells for over one year, indicating that Bmi1-positive cells are long-term lingual epithelial stem cells. In addition, we have developed a novel lingual epithelium organoid culture system using a three-dimensional matrix and growth factors. Here, we discuss current progress in the identification of lingual stem cells and future applications of the lingual culture system for studying the regulatory mechanisms of the lingual epithelium and for regenerative medicine.     

Ultrastructure of dermal denticles in sharpnose shark (Rhizoprionodon lalandii) (Elasmobranchii,Carcharhinidae)

The presence of denticles in the external surface, oral cavity, fins, and clasper of Elasmobranchii has been widely reported. These structures, called body denticles, may be observed on the body surface of sharks. Dermal and oral denticles are made up by a basal plate that is embedded in the dermis, forming a peduncle that grows from the base to the crown. These denticles may protect the skin against abrasion, and improve hydrodynamics and gill arches function. Rhizoprionodon lalandii is a widely distributed and very common species in Brazilian coastal areas. The aims of this study was to compare the morphology of oral and body denticles of R. lalandii to understand the implications of these structures in the behavior of these animals. Morphological analysis showed that there are differences between dermal and oral denticles, which are related to their role in different body regions. Body denticles have three cusps, and well‐defined crests and ridges, and literature data suggest that suggest that hydrodynamics is their main function. Most of the oral denticles have only one cusp, and their morphology and distribution showed that their main functions are preparing food to be swallowed and protecting the oral cavity against abrasion. Microsc. Res. Tech. 78:859–864, 2015. © 2015 Wiley Periodicals, Inc.     

Effect of method of delivery of sodium butyrate on rumen development in newborn calves

The effect of sodium butyrate (SB) supplementation in milk replacer (MR) or in starter mixture (SM) or in both MR and SM on performance, selected blood parameters, and rumen development in newborn calves was determined. Twenty-eight male calves with a mean age of 5 (±1) d were randomly allocated into 1 of 4 groups (7 animals per group) and fed (1) MR and SM, both without SB (MR⁻ and SM⁻, respectively); (2) MR⁻ and SM supplemented with SB encapsulated within a triglyceride matrix (SM⁺, 0.6% as fed; 30:70 butyrate-to-triglyceride matrix); (3) MR supplemented with crystalline SB (MR⁺, 0.3% as fed) and SM⁻; or (4) MR⁺ and SM⁺. The MR was offered in an amount equal to 10% of the initial body weight (BW) of each calf. The SM was blended with whole corn grain (50/50; wt/wt) and offered ad libitum as a starter diet (0.3% encapsulated-within-triglyceride matrix SB when SM⁺ was fed) from the first day of the trial. Calves were slaughtered at d 21 of a trial (mean age 26 ± 1 d). Addition of SB into MR (MR⁺) positively affected BW and average daily gain, tended to decrease the number of days with electrolyte therapies from d 0 to 7, and tended to positively affect fecal consistency from d 8 to 14 of the trial. Inclusion of SB into SM (SM⁺) increased starter diet intake from d 15 to 21, decreased the number of days with scours, and tended to decrease the number of days with electrolyte therapies in the whole trial period. Both MR⁺ and SM⁺ increased plasma glucose in the whole trial period and MR⁺ increased total serum protein at d 14. The SM⁺ increased plasma glucagon-like peptide-2 (GLP-2) concentration at d 7 of the trial when compared with the concentration at d 0. Both MR⁺ and SM⁺ increased reticulorumen weight and papillae length and width. Based on these results, it can be concluded that addition of SB in MR positively affected BW gain, health, and some metabolic intermediates of calves and it stimulated rumen development indirectly, whereas SB supplementation in SM stimulated rumen development directly. Addition of SB both in MR and SM could be recommended for rearing calves.     

间接喉镜下Nd:YAG激光治疗舌扁桃体角化症的疗效观察

目的:观察间接喉镜下利用Nd:YAG激光治疗舌扁桃体角化症的疗效。方法:在间接喉镜下采用自制的弯形激光切割器切除舌扁桃体角化症120例。结果:随访6个月至1年,治愈率71%,显效率12.7%。有效率11.8%,无效率4.5%。结论:该手术操作简单,术中出血少,术后不易复发,病人痛苦小,是治疗舌扁桃体角化症的一种较为理想的手术方法,值得推广使用。     

Comparison between two different methods for evaluating rumen papillae measures related to different diets

Although the Geographical Information System (GIS), which integrates computerized drawing computer assisted design (CAD) and relational databases (data base management system (DBMS)), is best known for applications in geographical and planning cartography, it can also use many kinds of information concerning the territory. A multidisciplinary project was initiated since 5 years a multidisciplinary study was initiated to use GIS to integrate environmental and ecological data with findings on animal health, ethology, and anatomy. This study is chiefly aimed at comparing two different methods for measuring the absorptive surface of rumen papillae. To this scope, 21 female sheep (Ovis aries) on different alimentary regimes (e.g., milk and forage mixed diet, early herbaceous diet, dry hay diet, and fresh hay diet at the maximum of pasture flowering and at the maximum of pasture dryness) were used; after slaughtering, 20 papillae were randomly removed from each sample collected from four indicator regions of rumen wall, placed near a metric reference and digitally photographed. The images were developed with the ArcGIS? software to calculate the area of rumen papillae by means of GIS and to measure their mid‐level width and length to calculate the papillae area as previously performed with a different method. Spatial measurements were analyzed using univariate and multivariate methods. This work demonstrates that the GIS methodology can be efficiently used for measuring the absorptive surface of rumen papillae. In addition, GIS demonstrated to be a rapid, precise, and objective tool when compared with previously used method. Microsc. Res. Tech. 2012. © 2012 Wiley Periodicals, Inc.