Recent Development of Photothermal Agents (PTAs) Based on Small Organic Molecular Dyes

Photothermal therapy (PTT) has attracted great attention due to its noninvasive and effective use against cancer. Various photothermal agents (PTAs) including organic and inorganic PTAs have been developed in the last decades. Organic PTAs based on small-molecule dyes exhibit great potential for future clinical applications considering their good biocompatibility and easy chemical modification or functionalization. In this review, we discuss the recent progress of organic PTAs based on small-molecule dyes for enhanced PTT. We summarize the strategies to improve the light penetration of PTAs, methods to enhance their photothermal conversion efficiency, how to optimize PTAs’ delivery into deep tumors, and how to resist photobleaching under repeated laser irradiation. We hope that this review can rouse the interest of researchers in the field of PTAs based on small-molecule dyes and help them to fabricate next-generation PTAs for noninvasive cancer therapy.     

数字散斑干涉技术及应用

介绍了数字散斑干涉技术在位移、应变、振动和医学诊断等领域中的应用和国内外发展状况。提出了一种新的应用领域—数字散斑干涉技术在语音识别中的应用,并对该方法作了介绍,讨论了它的特点。     

综合孔径微波辐射计二阶量化数字相关器研究

微波辐射计作为一种无源遥感器,在遥感技术领域有着巨大的应用前景.传统的微波辐射计的空间分辨率受到天线孔径的限制.综合孔径微波辐射计利用了干涉测量原理和复相关技术,是一种可以有效地提高空间分辨率的新型辐射计.本文针对综合孔径微波辐射计的数字相关器进行了深入研究,分析论证了二阶量化数字相关器的工作机理,并对采用该种相关器的系统的信噪比进行了分析.初步的试验验证结果证明了该方案的有效性.     

正交双频光栅CCD系统剪切干涉测量二维温度场

以半导体激光器为光源，利用正交双频光栅（ＯＤＦＧ）ＣＣＤ系统剪切干涉对带平板边界的半圆柱体热源的二维温度场进行实时诊断，分析剪切干涉图时，用柱函数系作为拟合基底，给出二维自然对流温度场的定量分布。     

溶液扩散系数自动测量系统

结合实时法全息干涉计量和数字图象处理技术，提出了一种溶液扩散系数的自动测量系统。在干涉图的处理中，采用了相位检测和曲线拟合技术，得到了亚象素的测量精度。     

激光在材料中感生的瞬态光声波和光热波

研究了锁模激光在材料中产生频率达GHz的光声波和相应探测技术,用回波分析法无损坏测量了薄材料的厚度。研究了激光在材料中感生的光热波,热沉测量可用于解释材料的破坏机理。     

非对称型外差激光探针

本文描述用于检测微振动的非对称型外差激光探针系统及实验结果。实验数据表明,系统检测灵敏度为1×10~(-4)nm/(Hz)~1/2将本系统用于检测薄膜电路在交变电热下的微振动以及表面波聚焦换能器的辐射声场分布,得到满意的结果。     

动态全息图快速引入背景条纹技术

音叉振动镜快速引入背景条纹的动态全息图两次曝光法，适用于一次泵浦的双脉冲全息干涉计量术．其背景条纹的密度和方向具有可调性和重复性．     

脉冲啁啾对干涉相关测宽的影响及其消除方法

本文深入讨论了脉冲啁啾的非线性起源及其对干涉相关测宽(等值宽度和条纹计数)法的影响。提出根据干涉相关曲线下包络最大值位置适当降低等值宽度位置和用计算机平均处理干涉相关信息的技术以消除啁啾的影响。     

Optical measurements of thermal diffusivity of a material

The measurement of thermal diffusivity of a material (in particular, a thin film) is important for various reasons, e.g., to predict the heat transfer in the solid subjected to a thermal process, to monitor surface composition or morphology, or to detect invisible subsurface defects like delaminations. This measurement can be done in a noncontact manner using various photothermal methods. Such methods typically involve pulsed heating of the surface by small amounts using a laser source; the decay of the surface temperature after this pulsed photothermal heating is then probed to provide the thermal diffusivity. Various probing methods have been developed in the literature, including the probing of reflection, refraction, and diffraction from the pulsed heated area, infrared thermal radiometry, and surface deformation. This paper provides an overview of such techniques and some examples of their applications.