Resveratrol as Chemosensitizer Agent: State of Art and Future Perspectives

Resistance to chemotherapy still remains a major challenge in the clinic, impairing the quality of life and survival rate of patients. The identification of unconventional chemosensitizing agents is therefore an interesting aspect of cancer research. Resveratrol has emerged in the last decades as a fascinating molecule, able to modulate several cancer-related molecular mechanisms, suggesting a possible application as an adjuvant in cancer management. This review goes deep into the existing literature concerning the possible chemosensitizing effect of resveratrol associated with the most conventional chemotherapeutic drugs. Despite the promising effects observed in different cancer types in in vitro studies, the clinical translation still presents strong limitations due to the low bioavailability of resveratrol. Recently, efforts have been moved in the field of drug delivery to identifying possible strategies/formulations useful for a more effective administration. Despite the necessity of a huge implementation in this research area, resveratrol appears as a promising molecule able to sensitize resistant tumors to drugs, suggesting its potential use in therapy-refractory cancer patients.     

Optimal design of nonlinear model predictive controller based on new modified multitracker optimization algorithm

The controller design for the robotic manipulator faces different challenges such as the system's nonlinearities and the uncertainties of the parameters. Furthermore, the tracking of different linear and nonlinear trajectories represents a vital role by the manipulator. This paper suggests an optimal design for the nonlinear model predictive control (NLMPC) based on a new improved intelligent technique and it is named modified multitracker optimization algorithm (MMTOA). The proposed modification of the MTOA is carried out based on opposition-based learning (OBL) and quasi OBL approaches. This modification improves the exploration behavior of the MTOA to prevent it from becoming trapped in a local optimum. The proposed method is applied on the robotic manipulator to track different linear and nonlinear trajectories. The NLMPC parameters are tuned by the MMTOA rather than the trial and error method of the designer. The proposed NLMPC based on MMTOA is compared with the original MTOA, genetic algorithm, and cuckoo search algorithm in literature. The superiority and effectiveness of the proposed controller are confirmed to track different linear and nonlinear trajectories. Furthermore, the robustness of the proposed method is emphasized against the uncertainties of the parameters.     

中医学视角下城市物质空间的生命要素探析

通过借鉴中医学整体观和生命观的相关理论,从认识城市有机体的生命属性入手,发现并提炼能够产生和传递城市运营所需各种能量的生命要素:廊道和功能体。阐释了其多层级、多性质和多形态的特点,提出了功能体有动力、廊道成系统、敏感点有活力的疏通策略,旨在促进城市各种能量的有机循环,从而维护城市的健康与安全,提高城市生活的效率与质量。     

Event-triggered variable horizon Supervisory Predictive control of hybrid power plants

The supervision of a hybrid power plant, including solar panels, a gas microturbine and a storage unit operating under varying solar power profiles is considered. The Economic Supervisory Predictive controller assigns the power references to the controlled subsystems of the hybrid cell using a financial criterion. A prediction of the renewable sources power is embedded into the supervisor. Results deteriorate when the solar power is unsteady, owing to the inaccuracy of the predictions for a long-range horizon of 10 s. The receding horizon is switched between an upper and a lower value according to the amplitude of the solar power trend. Theoretical results show the relevance of horizon switching, according to a tradeoff between performance and prediction accuracy. Experimental results, obtained in a Hardware In the Loop (HIL) framework, show the relevance of the variable horizon approach. Power amplifiers allow us to simulate virtual components, such as a gas microturbine, and to blend their powers with that of real devices (storage unit, real solar panels). In this case, fuel savings, reaching 15%, obtained under unsteady operating conditions lead to a better overall performance of the hybrid cell. The overall savings obtained in the experiments amount to 12%.     

MIMO系统的约束广义预测控制

讨论了输出终端带不等式约束情形的多输入多输出系统，说明了这些约束可以通过修改输入柔化系数而使其得以满足，在柔化系数的选择范围确定过程中，为了避免矩阵求逆，采用利用已知数据辨识参数的方法来确定柔化系数，从而使得问题简化。降低了计算量且加快了收敛速度。     

动态矩阵控制在浆料浓度控制系统中的应用

针对PTA生产中浆料配制过程这一有纯滞后、大时间常数的非线性系统，进行系统的动态机理分析，与工作点附近的线性化，在此基础上设计DMC-PID串级加前馈控制方案。目前该系统在扬子石化化工厂PTA装置上已成功投运。     

液力联轴器喷油着火事故的原因分析及预防

以矿用液力联轴器为研究对象 ,阐明其喷油着火的机理 ,分析其喷油着火的原因并作出事故树分析 ,针对现场使用的情况 ,提出预防措施及发展趋势 ,对矿井安全生产具有指导性作用。     

The five elements and chinese-american mortality.

D. P. Phillips, T. E. Ruth, and L. M. Wagner (1993) reported that 1969-1990 California mortality data show that Chinese Americans are particularly vulnerable to diseases that Chinese astrology and traditional Chinese medicine associate with their birth years. For example, because fire is associated with the heart, a Chinese person born in a fire year (such as 1937) is more likely to die of heart disease than is a Chinese person born in a nonfire year. However, many diseases were excluded from this study, some diseases that were included have ambiguous links to birth years, and the statistical tests were indirect. A more complete statistical analysis and independent California mortality data for the years 1960-1968 and 1991-2002 did not replicate the original results. (PsycINFO Database Record (c) 2010 APA, all rights reserved)