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To explore the effect of puerarin on insulin receptor (IR), insulin receptor substrate-1 (IRS-1) and protein expression of protein kinase B(PKB) in the P13K pathway of the glucose consumption, transportation and insulin signal transduction in 3T3-L1 adipocytes with insulin resistance. The insulin resistance 3T3-L1 adipocytes model was established by free fatty acid induction. The model cells were managed with puerarin in different concentrations. Glucose consumption was detected with glucose oxidase method, glucose transportation rate was determined by 2-deoxy-3H glucose ingesting method, and the IR, IRS-1 and PKB expression were determined by Western blot. Glucose consumption and transportation were significantly decreased in the model adipocytes, but increased after treated with puerarin (P<0.01). Moreover, the level of tyrosine phosphorylation of IR subunit β was higher in the puerarin treated groups, and that of IRS-1 was higher in the group treated with low dose puerarin than that in the model group. The 3T3-L1 adipocytes of insulin resistance model could be induced by free fatty acid successfully, puerarin could promote the glucose utilization in them to alleviate the insulin resistance, which may be related with the action in advancing the tyrosine phosphorylation of IR and IRS-1. 相似文献
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为了设计用超临界流体抗溶剂结晶(GAS)法制备葛根素的超细颗粒,用静态平衡法考察了超临界CO2溶胀过程中葛根素在乙醇溶液的溶解特性.实验结果表明,体系压力变化对溶解度的影响最为显著.同时,我们发现,伴随着体系压力的递增,溶液中葛根素浓度表现为先扬后抑的趋势,甚至大于其初始值.由此可知,GAS过程CO2兼有抗溶剂和萃取剂的双重功能:前者降低溶质的溶解度,后者则提高溶液浓度. 相似文献
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建立了富含葛根素的纳豆胶囊中葛根素的高效液相色谱分析方法。样品经过体积分数70%的甲醇提取后,采用ZORBAX ODS C18(5 μm, 4.6 mm×200 mm)色谱柱分离,以甲醇-36%乙酸-水(25∶3∶72)为流动相进行洗脱,流速1.0 mL/min,紫外检测波长247 nm。结果表明,葛根素在0~1 000 mg/L范围内线性关系良好(R2=0.999 4),检出限是0.005 mg/g。在10 mg/g、20 mg/g、30 mg/g添加水平下葛根素的平均回收率为99.5%~104.5%,相对标准偏差为3.8%。该方法简单快速、回收率高、准确性好,可用于富含葛根素的纳豆胶囊中葛根素含量分析。 相似文献
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《Drug development and industrial pharmacy》2013,39(6):826-835
An efficient and solvent-free procedure was developed to improve the solubility and bioavailability of the poorly water-soluble drug puerarin by mechanochemical technology. The stable inclusion complex of puerarin and 2-hydroxypropyl-β-cyclodextrin (HPCD) was prepared by a ball mill under the following conditions: equimolar ratio of puerarin to HPCD; rotational speed of 250 rpm; milling time of 90 min; steel balls of 22 mm diameter. The solid complex was characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), powder X-ray diffractometry (XRD), and fourier transformation-infrared spectroscopy (FT-IR). Mechanochemical action could result in enhanced molecular encapsulation, homogeneous distribution and amorphization of the drug. In comparison to puerarin, a 1.64-fold increase in absolute bioavailability was obtained. The solubility of the inclusion complex was 25.33-fold higher and the drug release amount reached 79.44% at 15 min, 2.76-fold higher. 相似文献
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选用健康的1日龄的樱桃谷鸭128只,在基础日粮预饲一周后,分别饲喂在基础日粮中添加不同水平葛根素的日粮,于21日龄屠宰对血清及骨骼里的钙、磷及相关指标进行检测.结果表明:低水平的葛根素(5 mg/kg)对骨的形成有利,可以有效阻止骨的吸收,促进骨的形成;高水平的葛根素对骨的形成不利,其主要作用机理是雌激素样作用. 相似文献
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采用固体分散技术制备葛根素亲水凝胶缓释片。先采用单因素实验制备葛根素固体分散体,然后通过正交试验考察HPMC的K4M型和K15M型的质量比m(K4M):m(K15M)(A),HPMC的质量分数(B),淀粉与乳糖质量比m(淀粉):m(乳糖)(C),淀粉与乳糖合计的质量分数(D)4个因素对葛根素亲水凝胶缓释片的影响。得到葛根素固体分散体的最佳制备工艺:以PEG4000为载体,药物与载体的质量比为1:6;葛根素亲水凝胶缓释片的最佳制备工艺为:HPMC的K4M型和K15M型质量比m(K4M):m(K15M)=1:2,HPMC的质量分数为片重的30%,淀粉与乳糖的质量比m(淀粉):m(乳糖)=1:3,淀粉与乳糖合计的质量分数为片重的40%。该缓释片处方合理,工艺可行,达到缓释的预期目的。 相似文献