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1.
《工程(英文)》2020,6(10):1170-1177
Diabetes and its related metabolic disorders have been reported as the leading comorbidities in patients with coronavirus disease 2019 (COVID-19). This clinical study aims to investigate the clinical features, radiographic and laboratory tests, complications, treatments, and clinical outcomes in COVID-19 patients with or without diabetes. This retrospective study included 208 hospitalized patients (≥ 45 years old) with laboratory-confirmed COVID-19 during the period between 12 January and 25 March 2020. Information from the medical record, including clinical features, radiographic and laboratory tests, complications, treatments, and clinical outcomes, were extracted for the analysis. 96 (46.2%) patients had comorbidity with type 2 diabetes. In COVID-19 patients with type 2 diabetes, the coexistence of hypertension (58.3% vs 31.2%), coronary heart disease (17.1% vs 8.0%), and chronic kidney diseases (6.2% vs 0%) was significantly higher than in COVID-19 patients without type 2 diabetes. The frequency and degree of abnormalities in computed tomography (CT) chest scans in COVID-19 patients with type 2 diabetes were markedly increased, including ground-glass opacity (85.6% vs 64.9%, P < 0.001) and bilateral patchy shadowing (76.7% vs 37.8%, P < 0.001). In addition, the levels of blood glucose (7.23 mmol·L−1 (interquartile range (IQR): 5.80–9.29) vs 5.46 mmol·L−1 (IQR: 5.00–6.46)), blood low-density lipoprotein cholesterol (LDL-C) (2.21 mmol·L−1 (IQR: 1.67–2.76) vs 1.75 mmol·L−1 (IQR: 1.27–2.01)), and systolic pressure (130 mmHg (IQR: 120–142) vs 122 mmHg (IQR: 110–137)) (1 mmHg = 133.3 Pa) in COVID-19 patients with diabetes were significantly higher than in patients without diabetes (P < 0.001). The coexistence of type 2 diabetes and other metabolic disorders is common in patients with COVID-19, which may potentiate the morbidity and aggravate COVID-19 progression. Optimal management of the metabolic hemostasis of glucose and lipids is the key to ensuring better clinical outcomes. Increased clinical vigilance is warranted for COVID-19 patients with diabetes and other metabolic diseases that are fundamental and chronic conditions. 相似文献
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Crossover designs are an extremely useful tool to investigators, and group sequential methods have proven highly proficient at improving the efficiency of parallel group trials. Yet, group sequential methods and crossover designs have rarely been paired together. One possible explanation for this could be the absence of a formal proof of how to strongly control the familywise error rate in the case when multiple comparisons will be made. Here, we provide this proof, valid for any number of initial experimental treatments and any number of stages, when results are analyzed using a linear mixed model. We then establish formulae for the expected sample size and expected number of observations of such a trial, given any choice of stopping boundaries. Finally, utilizing the four-treatment, four-period TOMADO trial as an example, we demonstrate that group sequential methods in this setting could have reduced the trials expected number of observations under the global null hypothesis by over 33%. 相似文献
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文中详细地阐述了取河水、井水、水库水、跨流城引(排)水等不同情况进行还原的具体方法步骤。并对水量还原成果提出合理性检查措施。 相似文献
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网页服务器用来传递或处理各种信息,网络攻击手法日新月异,造成诸多攻击手法可以很容易地被实现,多数的入侵检测系统以入侵特征规则作为检测基础,仅能对已知的弱点做有效的检测;提出一个适用于网页服务器的应用型入侵检测模块,将检测模块直接嵌入于网页服务器中,以“异常行为检测”和“错误行为检测”的办法,确认攻击类型,有效地预防新型攻击行为与检测已知攻击事件,对提高系统的安全性有重要作用。 相似文献
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喷锚网支护可提高高且陡的边坡岩土结构强度和抗变形刚度,增强边坡的整体稳定性.根据公路路段的情况,路堑边坡采用喷锚网支护的形式,针对设计方案、材料要求、施工方法、技术措施,以及现场质量管理和检测问题进行探讨. 相似文献
8.
This study investigated the ability of the Millon Clinical Multiaxial Inventory--Third Edition (MCMI-III) to discriminate students malingering psychopathology (n=106) from bona fide psychiatric inpatients (n=202). Students were randomly assigned to a fake-bad or an honest-responding condition. Analyses investigated the ability of the modifier indices to discriminate fake-bad group participants from the psychiatric inpatients. Scale X raw cutoff score >178 yielded a positive predictive power (PPP) of 0.0, a negative predictive power (NPP) of 63.1, and a hit rate of 63.1%. Optimal cutoff scores were developed. Scale X Base Rate (BR) >84 provided a PPP of 55.6, an NPP of 72.1, and a hit rate of 65.2%. Scale Y BR 相似文献
9.
工业工程继续教育和高等教育自学考试方案研究 总被引:1,自引:0,他引:1
根据作者参与工业工程(IE)研究和学术活动的实践,阐述了如何把学习国外先进经验与中国国情相结合,并以机电制造工业为主要对象,研究和设计了IE专业继续教育和高等教育自学考试教学计划。同时说明了该计划的实施,为大批培养社会迫切需要的IE人才创造了条件,并对我国IE学科建设起到了积极的推动作用。 相似文献
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