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1.
William M. Pitts Martin Werrel Marco Fernandez Mary A. Long Evan A. Eisenberg James Filliben Cory D. Runyon 《火与材料》2021,45(1):127-154
Fire spread and growth on real‐scale four cushion mock‐ups of residential upholstered furniture (RUF) were investigated with the goal of identifying whether changes in five classes of materials (barrier, flexible polyurethane foam, polyester fiber wrap, upholstery fabric, and sewing thread), referred to as factors, resulted in statistically significant changes in burning behavior. A fractional factorial experimental design plus practical considerations yielded a test matrix with 20 material combinations. Experiments were repeated a minimum of two times. Measurements included fire spread rates derived from video recordings and heat release rates (HRRs). A total of 13 experimental parameters (3 based on the videos and 10 on the HRR results), referred to as responses, characterized the measurements. Statistical analyses based on Main Effects Plots (main effects) and Block Plots (main effects and factor interactions) were used. The results showed that three of the factors resulted in statistically significant effects on varying numbers of the 13 responses. The Barrier and Fabric factors had the strongest main effects with roughly comparable magnitudes. Foam was statistically significant for fewer of the responses and its overall strength was weaker than for Barrier and Fabric. No statistically significant main effects were identified for Wrap or Thread. Multiple two‐term interactions between factors were identified as being statistically significant. The Barrier*Fabric interaction resulted in the highest number of and strongest statistically significant effects. The existence of two‐term interactions means that it will be necessary to consider their effects in approaches designed to predict the burning behavior of RUF. 相似文献
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根据催化裂化装置工艺流程要求及工艺设备的特点,对装置能量回收部分的三旋框架平面布置进行了详细的论述和分析;并结合设计经验及现场施工情况,提出了管道设计中应注意的一些问题。 相似文献
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文化的意识形态特征,使环境艺术设计过程中的文化构思成为整体设计方案的灵魂。通过充分的文化构思准备,明确的构思立意以及具体深入的构思表现,具体而合理的呈现出文化构思的思维脉络,有利于突出环境艺术设计创作的精神性和创新性,并保证设计与实施的顺利进行。 相似文献
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为了减少传统动画制作中手工劳动,实现高效的动画剧本创作,提出了一种面向交互式动画创作的结构化动画剧本生成模型并加以实现。通过一个实际样例阐述了该模型在剧本生成过程的具体应用,并对其结果进行分析,验证了模型的有效性。 相似文献
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台北市近年来大力推动都市更新,企图运用城市规划的容积金融化手段,克服和转移都市领域的积累与再生产困局,然而却因为2012年一户人家的拆迁,爆发了激烈的社会运动抵抗.本文指出都市更新容积奖励作为“国家机器”历史地打造的虚拟商品机制,牵涉庞大的利害关系,驱动了家园的强制金融化,加剧了资本对于都市纹理和社群关系的破坏,然其治理所需的制度镶嵌,远超出地方政府的制度能力及可问责性,以至公共利益被粗糙界定,形成对都市社会的巨大破坏力;而作为社会自体防御的都市运动展开结盟抗争,企图将脱缰的金融化都市发展,重新镶嵌到社会可以掌握的范围. 相似文献
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Hakan Kayir Bryan W. Jenkins Begüm Alural Jibran Y. Khokhar 《International journal of molecular sciences》2022,23(7)
Patients with schizophrenia, and rodent models of the disease, both exhibit suppressed neurogenesis, with antipsychotics possibly enhancing neurogenesis in pre-clinical models. Nestin, a cytoskeletal protein, is implicated in neuronal differentiation and adult neurogenesis. We hypothesized that schizophrenia pathogenesis involves nestin downregulation; however, few studies have related nestin to schizophrenia. We assessed nestin protein concentration, prepulse inhibition (PPI), and social interaction in the MK-801 model of schizophrenia, with or without antipsychotic (clozapine) treatment. Adult male Sprague–Dawley rats were intraperitoneally administered saline or MK-801 (0.1 mg/kg) to produce a schizophrenia-like phenotype, with concomitant subcutaneous injections of vehicle or clozapine (5 mg/kg). PPI was assessed on days 1, 8, and 15, and social interaction was assessed on day 4. Hippocampus tissue samples were dissected for Western blotting of nestin concentration. MK-801 alone did not alter nestin concentration, while clozapine alone enhanced hippocampal nestin concentration; this effect was not apparent in animals with MK-801 and clozapine co-administration. MK-801 also produced schizophrenia-like PPI disruptions, some of which were reversed by clozapine. Social interaction deficits were not detected in this model. This is the first report of clozapine-induced enhancements of hippocampal nestin concentration that might be mediated by NMDA receptors. Future studies will explore the impact of neurodevelopmental nestin concentration on symptom onset and antipsychotic treatment. 相似文献
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