Fat Distribution and Lipid Profile of Young Adults with Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Enzyme Deficiency

We aimed to compare detailed fat distribution and lipid profile between young adults with congenital adrenal hyperplasia due to 21-hydroxylase enzyme deficiency and a control group. We also verified independent associations of treatment duration and daily hydrocortisone dose equivalent (HDE) with lipid profile within patients. This case–control study included 23 patients (7 male and 16 female) matched by an age range of young adults (18–31 years) with 20 control subjects (8 male and 12 female). Dual energy X-ray absorptiometry was used to measure the fat distribution. Male patients demonstrated elevated indices of fat mass for total (7.7 ± 2.1 vs. 4.5 ± 1.3 kg/m², p = 0.003), trunk (4.0 ± 1.2 vs. 2.2 ± 0.8 kg/m², p = 0.005), android (0.63 ± 0.24 vs. 0.32 ± 0.15 kg/m², p = 0.008), gynoid (1.34 ± 0.43 vs. 0.74 ± 0.24 kg/m², p = 0.005), arm (0.65 ± 0.16 vs. 0.39 ± 0.10 kg/m², p = 0.009), and leg regions (2.7 ± 0.8 vs. 1.6 ± 0.4 kg/m², p = 0.005) than the control group, but not in females. However, female patients demonstrated elevated ratio of low-density lipoprotein cholesterol to high-density lipoprotein cholesterol (1.90 ± 0.46 vs. 1.39 ± 0.47, p = 0.009) than the control group, but not in males. Total fat mass was inversely correlated with total testosterone (r = −0.64, p = 0.014) and positively correlated with leptin in males (r = 0.75, p = 0.002). An elevated daily HDE (β = 0.43, p = 0.038 and β = 0.47, p = 0.033) and trunk to total fat mass ratio (β = 0.46, p = 0.025, and β = 0.45, p = 0.037) were independently correlated with impaired lipid profile markers. Although there is no altered lipid profile, male patients demonstrated an increased fat distribution. However, female patients presented with an impaired lipid profile marker but demonstrated close values of normal fat distribution. Interestingly, the dose of glucocorticoid therapy can have some role in the lipid mechanisms.     

The Role of Cell Cycle Regulators in Cell Survival—Dual Functions of Cyclin-Dependent Kinase 20 and p21Cip1/Waf1

The mammalian cell cycle is important in controlling normal cell proliferation and the development of various diseases. Cell cycle checkpoints are well regulated by both activators and inhibitors to avoid cell growth disorder and cancerogenesis. Cyclin dependent kinase 20 (CDK20) and p21^Cip1/Waf1 are widely recognized as key regulators of cell cycle checkpoints controlling cell proliferation/growth and involving in developing multiple cancers. Emerging evidence demonstrates that these two cell cycle regulators also play an essential role in promoting cell survival independent of the cell cycle, particularly in those cells with a limited capability of proliferation, such as cardiomyocytes. These findings bring new insights into understanding cytoprotection in these tissues. Here, we summarize the new progress of the studies on these two molecules in regulating cell cycle/growth, and their new roles in cell survival by inhibiting various cell death mechanisms. We also outline their potential implications in cancerogenesis and protection in heart diseases. This information renews the knowledge in molecular natures and cellular functions of these regulators, leading to a better understanding of the pathogenesis of the associated diseases and the discovery of new therapeutic strategies.     

基于实际井眼轨迹的抽油杆柱API设计方法

目前的抽油杆柱设计方法大都基于设计井眼轨迹或经验公式，因此设计的抽油杆柱与井眼的匹配性并没有达到最优，结果可能影响了抽油杆柱的受力特性和寿命。概述了目前现有的抽油杆柱设计方法，提出了基于实际井眼轨迹的抽油杆柱API设计方法，即考虑到在三维空间中井下粘滞阻力及动载的影响，利用微单元分析方法计算出轴向载荷与轴向应力，然后在此基础上进行杆柱组合设计，并给出了设计流程。以江苏油田永21-3井为例，对几种设计方法的设计结果进行了对比分析，结果表明，江苏油田目前采用的抽油杆柱设计方法包含了人为经验因素，并不是最优的杆柱设计结果，有待进一步改进。     

基于ADSP21XXC运行环境下FFT的实现

介绍了数字信号处理器ADSP21XX芯片的特点以及实现FFT(快速离散付里叶变换)的方法，给出了ADSP21XX的C和汇编混合编程的特点及技巧。     

EFFECT OF AGING ON HYDROGEN EMBRITTLEMENT SUSCEPTIBILITY OF STEEL Cr21Ni6Mn9N

Effects of 650℃ aging for 1—1000 h on structure and hydrogen embrittlement susceptibility(HES)of steel Cr21Ni6Mn9N have been investigated.The results show that M_(23)C_6 typecarbide precipitates at grain boundaries and Cr-depletive region appears beside them duringaging.The precipitates grow and connect each other as the aging time prolongs.Meanwhile,the degree of Cr-depletion aggravates first and then recovers gradually while the aging time isvery long,i.e.,1000 h.The HES of the steel increases with increasing aging time but does notreduce with the recovery of Cr content at the Cr-depletive region.That implies that the ex-isting of carbides at grain boundaries might be the main reason which promotes the HES ofsteel during aging.     

Flood Inundation Modelling for Mid‐Lower Brisbane Estuary

This study utilizes a two‐dimensional hydrodynamic model to calibrate and validate an inundation model for the Brisbane River estuary in Queensland, Australia. The bathymetry data used in the hydraulic model are derived from one arc second (1 s) shuttle radar topography mission digital elevation model, and the two‐dimensional hydraulic model is parameterized using the generated bathymetry with four open boundaries with water level observations and roughness coefficients. The calibration performance is evaluated by comparing the simulated results with the digitized records during the January 2013 flood event (a low magnitude event) at three gauging stations. The calibrated model is validated with water level data and available discharge data during the January 2011 flood (a large magnitude event) at four gauging stations located along the Brisbane River. Different performance indices are applied to demonstrate that the developed model performs well during calibration and validation. A sensitivity analysis is presented to assess the influence of riverbed elevation changes on the model because the main uncertainty of the model is the bathymetry data. The proposed model with the shuttle radar topography mission digital elevation model‐derived riverbed elevation for the Brisbane estuary is able to predict the flood inundation extent at an accuracy of 66.9% which is higher than or comparable with the accuracies of the existing studies. However, it is expected that the accuracy will increase if some improved bathymetry data become available in the future. Copyright © 2016 John Wiley & Sons, Ltd.     

近海人工岛及沙坝工程与潮流的响应特征研究

北戴河新区位于最具发展潜力的环渤海经济圈中心地带,为满足旅游业发展需要而建的人工岛和保护旅游海滩而建的人工沙坝对近海潮流动力有不同程度的影响。该文基于MIKE21 FM模块通过大、中、小模型三层嵌套的方式建立洋河-葡萄岛近岸海域潮流数学模型,研究分析人工岛及沙坝工程建设前后的潮流动力变化特征,得到下列主要结论:工程建设后研究区域的主体潮流特征仍为顺岸往复流,流速变化量涨潮大于落潮;人工岛工程对流速场的影响范围和程度均明显大于沙坝工程,其中人工岛工程引起的流速变化量是沙坝工程的4倍;人工岛的建设使其内部形成一个相对封闭的水域,流速近乎为零,而养滩工程区在两侧水工建筑物和水下人工沙坝的掩护作用下流速基本减小至0.10 m/s以下。     

铝合金搅拌摩擦焊焊接缺陷分析

采用搅拌摩擦焊方法对6mm厚的2A12及3A21铝合金进行焊接。对其焊接速度、旋转速度及压入量等工艺参数选择不当所产生的接头缺陷进行了分析;焊接缺陷的产生与焊接热输入及焊缝塑性金属的软化相关。当热输入不足或者塑性金属的软化程度较差时都会导致焊接缺陷的形成。     

包裹管道用3A21料冷轧工艺改进

针对包裹管道用3A21合金板材冷轧时表面油痕废品和表面花脸缺陷，提出了采用中间退火代替成品退火及控制中间退火后的冷轧变形量的改进工艺，同时调整3A21合金Mn的含量控制再结晶晶粒度。通过跟踪试验，改进工艺大大降低了成品表面油痕废品率，减少了板材表面花脸缺陷，保证了力学性能。     

新型TC21钛合金热处理工艺参数与显微组织演变的关系研究

TC21钛合金是新型的高强韧损伤容限型钛合金，其模锻件为网篮组织，锻后热处理工艺采用双重退火工艺。本研究采用金相法、SEM等方法系统研究了TC21钛合金模锻件的锻后热处理工艺和显微组织演变规律。试验分析了TC21钛合金模锻件锻后第1次退火加热温度、第2次退火加热温度和保温时间等工艺参数条件下的初生α相数量、形状以及网篮组织形貌特征的变化规律，为TC21钛合金模锻件获得高强、高韧和损伤容限优良综合性能奠定基础。