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1.
CUI Jianzhong MA Longxiang Northeast University of Technology Shenyang China Department of Metals Forming Northeast University of Technology Shenyang China 《金属学报(英文版)》1989,2(7):61-67
The method controlling grain shape in TMT processing and the effect of grain shape on char-acteristic parameters in superplastic deformation were discussed.The accommodation velocityof grahl boundary sliding,which is the dominant mechanism in superplastic deformation,andthe contribution of each mechanism to the total strain,as influenced by grain shape,were ana-lyzed.Grain shape has been shown to be an essential structural factor for superplasticity.Thenan analysis was made about the effect of grain shape on the region transition strain rate sothat a new concept,critical aspect for superplasticity,was worked out.These predictions werecompared with the measured results in an Al-Zn-Mg alloy. 相似文献
2.
Fatemeh Habibpourmehraban Yunqi Wu Jemma X. Wu Sara Hamzelou Farhad Masoomi-Aladizgeh Karthik Shantharam Kamath Ardeshir Amirkhani Brian J. Atwell Paul A. Haynes 《International journal of molecular sciences》2022,23(3)
Rice crops are often subject to multiple abiotic stresses simultaneously in both natural and cultivated environments, resulting in yield reductions beyond those expected from single stress. We report physiological changes after a 4 day exposure to combined drought, salt and extreme temperature treatments, following a 2 day salinity pre-treatment in two rice genotypes—Nipponbare (a paddy rice) and IAC1131 (an upland landrace). Stomata closed after two days of combined stresses, causing intercellular CO2 concentrations and assimilation rates to diminish rapidly. Abscisic acid (ABA) levels increased at least five-fold but did not differ significantly between the genotypes. Tandem Mass Tag isotopic labelling quantitative proteomics revealed 6215 reproducibly identified proteins in mature leaves across the two genotypes and three time points (0, 2 and 4 days of stress). Of these, 987 were differentially expressed due to stress (cf. control plants), including 41 proteins that changed significantly in abundance in all stressed plants. Heat shock proteins, late embryogenesis abundant proteins and photosynthesis-related proteins were consistently responsive to stress in both Nipponbare and IAC1131. Remarkably, even after 2 days of stress there were almost six times fewer proteins differentially expressed in IAC1131 than Nipponbare. This contrast in the translational response to multiple stresses is consistent with the known tolerance of IAC1131 to dryland conditions. 相似文献
3.
This study focuses on the relationship and identity changes within and between a project team and its organization following top management intervention in the context of a large international construction project. The study follows the project-as-practice orientation, examining the actions and behaviors of the project team through participant ethnography in the “praxis” of the project site over its entire duration. The longitudinal case allows the examination of the way the transition process established a new governance culture undermining the initial trust-based one and changed it from a virtual absence of mechanisms toward far more potent mechanisms of control, monitoring, and punishment. Simultaneously, the initial stewardship relationships and collectivist identity of the project team shifted toward agency relationships and individualistic identity. The triggers for the transformation process were identified as CEO succession, project failure, top management intervention driven changes in governance mechanisms, and perception of organizational betrayal of the project team. 相似文献
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Misara Hamoudeh Roudayna Diab Hatem Fessi Charles Dumontet Delphine Cuchet 《Drug development and industrial pharmacy》2013,39(7):698-707
In our pursuit to develop suitable therapeutic particulate systems for intratumoral delivery by the targeted multi-therapy (TMT) technique, we describe the preparation of paclitaxel-loaded poly(d,l-lactic-co-glycolic) acid (PLGA) microparticles (MPs) (drug loading 35–38%, wt/wt; size 0.7–5 μm). Magnetite (15%, wt/wt) was also incorporated in some preparations for a future magnetic resonance imaging (MRI)-guided delivery. X-ray diffraction (XRD) and differential scanning calorimetry (DSC) experiments showed that paclitaxel was not encapsulated in its initial crystalline form. The paclitaxel in vitro release pattern showed a biphasic tendency with a burst effect followed by a sustained release (28% released amount after 1 month), which was accompanied with MP erosion and degradation signs as confirmed by scanning electronic microscopy (SEM) micrographs. The paclitaxel-loaded MPs demonstrated a dose-dependent antitumor effect on human uterine cancer cells, with an IC50 value relatively close to that of commercial Taxol®. This paclitaxel delivery system represents a potent antiprofilerative and radiosensitizer agent for intratumoral administration via the TMT technique. 相似文献
8.
《分离科学与技术》2012,47(14):2231-2238
In this study, the recovery of silver from waste X-ray photographic solutions by precipitation using trimercapto-s-triazine (TMT) was studied. Taguchi L25 (53) orthogonal design was adopted for the study. The effects of concentration of thiosulphate (5.2–200 g/L), TMT (Ag:TMT = 6.6–2.2), temperature (20–60°C) and pH (4.37–8.00) on the extent of the precipitation of silver were investigated. The findings have shown that the concentration of TMT and pH are the most significant factors affecting the recovery of silver while the effect of temperature (20–60°C) is insignificant under the conditions tested. The increase in the concentration of TMT and pH was found to improve the extent of precipitation of silver. TMT was also found to be an effective agent to reduce silver concentrations below the regulatory limit value of 5 ppm. Characterization of the precipitates was performed to identify silver-TMT compounds formed. 相似文献
9.
Ahmad Abd-El-Aziz Angela Riveroll Blanca Esparza-Gonsalez Laurie McDuffee Alejandro M. Cohen Adam L. Fenech William J. Montelpare 《International journal of molecular sciences》2022,23(13)
The aim of this research was to determine the impact of heat stress on cell differentiation in an equine mesenchymal stem cell model (EMSC) through the application of heat stress to primary EMSCs as they progressed through the cell specialization process. A proteomic analysis was performed using mass spectrometry to compare relative protein abundances among the proteomes of three cell types: progenitor EMSCs and differentiated osteoblasts and adipocytes, maintained at 37 °C and 42 °C during the process of cell differentiation. A cell-type and temperature-specific response to heat stress was observed, and many of the specific differentially expressed proteins were involved in cell-signaling pathways such as Notch and Wnt signaling, which are known to regulate cellular development. Furthermore, cytoskeletal proteins profilin, DSTN, SPECC1, and DAAM2 showed increased protein levels in osteoblasts differentiated at 42 °C as compared with 37 °C, and these cells, while they appeared to accumulate calcium, did not organize into a whorl agglomerate as is typically seen at physiological temperatures. This altered proteome composition observed suggests that heat stress could have long-term impacts on cellular development. We propose that this in vitro stem cell culture model of cell differentiation is useful for investigating molecular mechanisms that impact cell development in response to stressors. 相似文献
10.
Ke Xu Yong Zhao Yaxin Yu Ruoxi Sun Weiwei Wang Shuhua Zhang Xueju Yang 《International journal of molecular sciences》2022,23(21)
Potassium (K+) is essential for plant growth and stress responses. A deficiency in soil K+ contents can result in decreased wheat quality and productivity. Thus, clarifying the molecular mechanism underlying wheat responses to low-K+ (LK) stress is critical. In this study, a tandem mass tag (TMT)-based quantitative proteomic analysis was performed to investigate the differentially abundant proteins (DAPs) in roots of the LK-tolerant wheat cultivar “KN9204” at the seedling stage after exposure to LK stress. A total of 104 DAPs were identified in the LK-treated roots. The DAPs related to carbohydrate and energy metabolism, transport, stress responses and defense, and post-translational modifications under LK conditions were highlighted. We identified a high-affinity potassium transporter (TaHAK1-4A) that was significantly up-regulated after the LK treatment. Additionally, TaHAK1-4A was mainly expressed in roots, and the encoded protein was localized in the plasma membrane. The complementation assay in yeast suggested that TaHAK1-4A mediates K+ uptake under extreme LK conditions. The overexpression of TaHAK1-4A increased the fresh weight and root length of Arabidopsis under LK conditions and improved the growth of Arabidopsis athak5 mutant seedlings, which grow poorly under LK conditions. Moreover, silencing of TaHAK1-4A in wheat roots treated with LK stress decreased the root length, dry weight, K+ concentration, and K+ influx. Accordingly, TaHAK1-4A is important for the uptake of K+ by roots exposed to LK stress. Our results reveal the protein metabolic changes in wheat induced by LK stress. Furthermore, we identified a candidate gene potentially relevant for developing wheat lines with increased K+ use efficiency. 相似文献