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1.
Raquel Cano Jos L. Prez Liss Angarita Dvila ngel Ortega Yosselin Gmez Nereida Josefina Valero-Cedeo Heliana Parra Alexander Manzano Teresa Isabel Vliz Castro María P. Díaz Albornoz Gabriel Cano Joselyn Rojas-Quintero Maricarmen Chacín Valmore Bermúdez 《International journal of molecular sciences》2021,22(9)
Non-alcoholic fatty liver disease (NAFLD) is considered the most common liver disorder, affecting around 25% of the population worldwide. It is a complex disease spectrum, closely linked with other conditions such as obesity, insulin resistance, type 2 diabetes mellitus, and metabolic syndrome, which may increase liver-related mortality. In light of this, numerous efforts have been carried out in recent years in order to clarify its pathogenesis and create new prevention strategies. Currently, the essential role of environmental pollutants in NAFLD development is recognized. Particularly, endocrine-disrupting chemicals (EDCs) have a notable influence. EDCs can be classified as natural (phytoestrogens, genistein, and coumestrol) or synthetic, and the latter ones can be further subdivided into industrial (dioxins, polychlorinated biphenyls, and alkylphenols), agricultural (pesticides, insecticides, herbicides, and fungicides), residential (phthalates, polybrominated biphenyls, and bisphenol A), and pharmaceutical (parabens). Several experimental models have proposed a mechanism involving this group of substances with the disruption of hepatic metabolism, which promotes NAFLD. These include an imbalance between lipid influx/efflux in the liver, mitochondrial dysfunction, liver inflammation, and epigenetic reprogramming. It can be concluded that exposure to EDCs might play a crucial role in NAFLD initiation and evolution. However, further investigations supporting these effects in humans are required. 相似文献
2.
Several three-party password authenticated key exchange (3-PAKE) protocols have recently been proposed for heterogeneous wireless sensor networks (HWSN). These are efficient and designed to address security concerns in ad-hoc sensor network applications for a global Internet of Things framework, where a user may request access to sensitive information collected by resource-constrained sensors in clusters managed by gateway nodes. In this paper we first analyze three recently proposed 3-PAKE protocols and discuss their vulnerabilities. Then, based on Radio Frequency Identification technologies we propose a novel 3-PAKE protocol for HWSN applications, with two extensions for additional security features, that is provably secure, efficient and flexible. 相似文献
3.
In this paper, we report on the indoor concentrations from a suite of full-scale outdoor tracer-gas point releases conducted in the downtown area of Oklahoma City in 2003. A point release experiment consisted of releases of sulfur hexafluoride (SF6) in multiple buildings and from different outdoor locations. From the measurements, we are able to estimate the concentration variations indoors for a building operating under “typical” operating conditions. The mean indoor spatial coefficients of variation are 30% to 45% from a daytime outdoor release are around 80% during an outdoor evening release. Having estimates of the spatial coefficient of variation provides stakeholders, including first responders, with the likely range of concentrations in the building when little is known about the building characteristics and operating behavior, such as developing urban-scale hazard and consequence analyses. We show differences in indoor measurements at different distances to the release points, floors of the building, and heating, ventilation, and air conditioning system (HVAC) operation. We also show estimates at different time resolutions. The statistics show that in the studied medium to large commercial buildings, spatial differences would result in peak indoor concentrations in certain parts of the buildings that may be substantially higher than the building average. To our knowledge, very few tracer gas measurements have been conducted in buildings of this scope, particularly with measurements on multiple floors and within a floor. The resulting estimates of spatial variability provide a unique opportunity for hazard assessment, and comparison to multi-zone models. 相似文献
4.
大气污染物排放清单是空气质量模拟和空气污染治理的重要依据.本研究比较分析了两套覆盖江苏省的2017年大气污染物排放清单,即分别由上海市环境科学研究院、江苏省环境科学研究院编制的"长三角清单"和"江苏省清单",并结合区域空气质量模型CMAQ评估不同清单对长三角地区2017年1、4、7、10月的空气质量模拟的影响.清单比较结果表明,除二氧化硫(SO2)以外,江苏省清单估算的各污染物排放量较长三角清单低.通过与观测数据比较,发现两套清单对SO2、氮氧化物(NOx)、臭氧(O3)和细颗粒物(PM2.5)的模型模拟性能均较好.江苏省清单与长三角清单两者的模拟结果空间分布接近,其中江苏省清单模拟的PM2.5和O3在长三角多数地区略低于长三角清单的模拟结果(1月O3除外).江苏省清单与长三角清单均能够用于空气质量模式模拟,可为江苏地区的细颗粒物和光化学烟雾污染的控制策略制定提供参考. 相似文献
5.
Private information retrieval(PIR) is an important privacy protection issue of secure multi-party computation, but the PIR protocols based on classical cryptography are vulnerable because of new technologies,such as quantum computing and cloud computing. The quantum private queries(QPQ) protocols available, however, has a high complexity and is inefficient in the face of large database. This paper, based on the QKD technology which is mature now, proposes a novel QPQ protocol utilizing the key dilution and auxiliary parameter. Only N quits are required to be sent in the quantum channel to generate the raw key, then the straight k bits in the raw key are added bitwise to dilute the raw key, and a final key is consequently obtained to encrypt the database. By flexible adjusting of auxiliary parameters θ and k, privacy is secured and the query success ratio is improved. Feasibility and performance analyses indicate that the protocol has a high success ratio in first-trial query and is easy to implement, and that the communication complexity of O(N) is achieved. 相似文献
6.
带关键字搜索的公钥加密(PEKS)是一种有用的加密原语,它允许用户将在加密数据上搜索的功能委托给不可信的第三方服务器,而不影响原始数据的安全性和隐私性。但是,由于缺乏对于数据的加密以及解密能力,PEKS方案不能单独进行使用,必须与标准的公钥加密方案(PKE)相结合。因此,Baek等人在2006年引入了一种新的加密原语,称为结合PKE和PEKS的加密方案(PKE+PEKS),它同时提供了PKE和PEKS的功能。目前,已有文献提出了几种PKE+PEKS方案。然而,他们都没有考虑关键字猜测攻击的问题。本文提出一个新的高效且能够抵抗关键字猜测攻击的PKE+PEKS方案,与已有方案相比,该方案在性能上有很大的提升,并且在生成关键字和数据密文时,不需要使用双线性对,极大地降低了计算和存储成本。安全性分析表明,本文中所提出的方案能够满足密文隐私安全性、陷门不可区分性和抗关键字猜测攻击的安全性。效率分析表明,本分提出的方案更加高效。 相似文献
7.
As the development of cloud computing and the convenience of wireless sensor netowrks, smart devices are widely used in daily life, but the security issues of the smart devices have not been well resolved. In this paper, we present a new NTRU-type public-key cryptosystem over the binary field. Specifically, the security of our scheme relies on the computational intractability of an unbalanced sparse polynomial ratio problem (DUSPR). Through theoretical analysis, we prove the correctness of our proposed cryptosystem. Furthermore, we implement our scheme using the NTL library, and conduct a group of experiments to evaluate the capabilities and consuming time of encryption and decryption. Our experiments result demonstrates that the NTRU-type public-key cryptosystem over the binary field is relatively practical and effective. 相似文献
8.
9.
带有传感器的可穿戴式医疗设备不断生成大量数据,由于数据的复杂性,难以通过处理和分析大数据来找到有价值的决策信息。为了解决这个问题,提出了一种新的物联网体系结构,用于存储和处理医疗应用的可扩展传感器数据(大数据)。所提出的架构主要由两个子架构组成:Meta Fog重定向(MF-R)架构和AWS密钥管理机制。MF-R架构使用Apache Pig和Apache HBase等大数据技术来收集和存储不同传感器设备生成的传感器数据,并利用卡尔曼滤波消除噪声。AWS密钥管理机制使用密钥管理方案,目的是保护云中的数据,防止未经授权的访问。当数据存储在云中时,所提出的系统能够使用随机梯度下降算法和逻辑回归来开发心脏病的预测模型。仿真实验表明,和其他几种算法相比,提出的算法具有更小的误差,且在吞吐量、准确度等方面具有一定的优越性。 相似文献
10.