The Multifaceted Mas-Related G Protein-Coupled Receptor Member X2 in Allergic Diseases and Beyond

Recent research on mast cell biology has turned its focus on MRGPRX2, a new member of the Mas-related G protein-coupled subfamily of receptors (Mrgprs), originally described in nociceptive neurons of the dorsal root ganglia. MRGPRX2, a member of this group, is present not only in neurons but also in mast cells (MCs), specifically, and potentially in other cells of the immune system, such as basophils and eosinophils. As emerging new functions for this receptor are studied, a variety of both natural and pharmacologic ligands are being uncovered, linked to the ability to induce receptor-mediated MC activation and degranulation. The diversity of these ligands, characterized in their human, mice, or rat homologues, seems to match that of the receptor’s interactions. Natural ligands include host defense peptides, basic molecules, and key neuropeptides such as substance P and vasointestinal peptide (known for their role in the transmission of pain and itch) as well as eosinophil granule-derived proteins. Exogenous ligands include MC secretagogues such as compound 48/80 and mastoparan, a component of bee wasp venom, and several peptidergic drugs, among which are members of the quinolone family, neuromuscular blocking agents, morphine, and vancomycin. These discoveries shed light on its capacity as a multifaceted participant in naturally occurring responses within immunity and neural stimulus perception, as in responses at the center of immune pathology. In host defense, the mice Mrgprb2 has been proven to aid mast cells in the detection of peptidic molecules from bacteria and in the release of peptides with antimicrobial activities and other immune mediators. There are several potential actions described for it in tissue homeostasis and repair. In the realm of pathologic response, there is evidence to suggest that this receptor is also involved in chronic inflammation. Furthermore, MRGPRX2 has been linked to the pathophysiology of non-IgE-mediated immediate hypersensitivity drug reactions. Different studies have shown its possible role in other allergic diseases as well, such as asthma, atopic dermatitis, contact dermatitis, and chronic spontaneous urticaria. In this review, we sought to cover its function in physiologic processes and responses, as well as in allergic and nonallergic immune disease.     

Mast Cell Chymase and Kidney Disease

A sizable part (~2%) of the human genome encodes for proteases. They are involved in many physiological processes, such as development, reproduction and inflammation, but also play a role in pathology. Mast cells (MC) contain a variety of MC specific proteases, the expression of which may differ between various MC subtypes. Amongst these proteases, chymase represents up to 25% of the total proteins in the MC and is released from cytoplasmic granules upon activation. Once secreted, it cleaves the targets in the local tissue environment, but may also act in lymph nodes infiltrated by MC, or systemically, when reaching the circulation during an inflammatory response. MC have been recognized as important components in the development of kidney disease. Based on this observation, MC chymase has gained interest following the discovery that it contributes to the angiotensin-converting enzyme’s independent generation of angiotensin II, an important inflammatory mediator in the development of kidney disease. Hence, progress regarding its role has been made based on studies using inhibitors but also on mice deficient in MC protease 4 (mMCP-4), the functional murine counterpart of human chymase. In this review, we discuss the role and actions of chymase in kidney disease. While initially believed to contribute to pathogenesis, the accumulated data favor a more subtle view, indicating that chymase may also have beneficial actions.     

双排桩门架—锚杆新型组合支护体系的应用研究

本文分析了双排桩门架支护结构的受力机理。针对工程实际进行变形分析,提出增设锚杆形成锚杆———双排桩门架式组合支护体系的方法,并与监测数据对比、验证。     

前开口无绷绳自举式钻机的结构和特点

阐述了前开口无绷绳自举式钻机的设计要求，分析了该钻机的结构特点。钻机的型式和基本参数符合SY／T5609—1999标准。各主要设备设计制造符合API相关规范及HSE的要求。该钻机可满足在钻井地域面积有限的情况下的使用要求，其特点及适用性时今后钻机的发展有一定的借鉴。     

Quality assessment of SRTM C- and X-band interferometric data: Implications for the retrieval of vegetation canopy height

The Shuttle Radar Topography Mission distinguished itself as the first near-global spaceborne mission to demonstrate direct sensitivity to vertical vegetation structure. Whether this sensitivity is viewed as exploitable signal or unwanted bias, a great deal of interest exists in retrieving vegetation canopy height information from the SRTM data. This study presents a comprehensive application-specific assessment of SRTM data quality, focusing on the characterization and mitigation of two primary sources of relative vertical error: uncompensated Shuttle mast motion and random phase noise. The assessment spans four test sites located in the upper Midwestern United States and examines the dependence of data quality on both frequency, i.e., C-band vs. X-band, and the number of acquired datatakes. The results indicate that the quality of SRTM data may be higher than previously thought. Novel mitigation strategies include a knowledge-based approach to sample averaging, which has the potential to reduce phase noise error by 43 to 80%. The strategies presented here are being implemented as part of an ongoing effort to produce regional- to continental-scale estimates of vegetation canopy height within the conterminous U.S.     

两种非常规曲面隧道洞门自制模型施工工艺

通过对井冈山铁路首次采用的旗式洞门波浪曲面及（斜切）翻檐式隧道洞门翻转面混凝土施工介绍,总结和分析了该工程施工特点,并提出了该类型曲面混凝土施工工法和施工控制关键,为今后的曲面洞门混凝土施工与控制提供一定的指导或鉴解。     

钻井井架力学性能分析

钻井井架作为钻机系统设备中的关键部分,其力学性能直接关系到整套钻机系统的安全生产。文章推导了常用于分析钻井井架力学性能的理论,即线性屈曲、几何非线性和双重非线性理论。提出同时用这三种理论对钻井井架进行综合比较分析,从而合理地预见井架力学性能的方法。以A形钻井井架为例,进行了详细的分析,得到了井架的失稳形式、极限承载、破坏特征及薄弱部位,为钻井井架的设计、优化与评定提供了参考。     

东津水电站引水隧洞进口不良地质段施工

东津水电站引水隧洞进口段工程地质条件恶劣，施工干扰大，渡汛工期紧。采用喷锚支护洞脸边坡，洞口明挖３ｍ浇筑钢筋混凝土明拱和Ｌ形护坡墙；洞身段采用新奥法施工，先打通上导洞；进口４０ｍ分段开挖，分段衬砌；进水塔压板混凝土模板采用门字框架钢支撑；排除了施工干扰，防止了洞口滑塌，进口段塌方的恶性事故发生，保证了引水隧洞工程的顺利施工。     

小高跨比单层单跨实腹门式刚架平面内弹性整体稳定分析

采用精确的有限元非线性分析方法对小高跨比单层单跨实腹门式刚架的平面内弹性整体稳定性进行了大量的参数分析，指出在梁上均布荷载作用下，当柱梁高跨比小于某一数值时，一般不发生传统理论所认为的反对称失稳模式，而是以对称失稳模式为主。给出了修正的柱计算长度系数，并与规范给出的数值进行了对比，认为这种对称失稳模式更不利于门式刚架的整体稳定，应该引起足够的重视。     

基于LabVIEW的医学影像学教学系统的设计

医学影像学一直是各医学院校教学的重点课程之一。本文通过基于LabVIEW软件制作成医学影像学肝门静脉图像教学系统供教学使用,并为临床诊断提供参考,实践证明取得了良好的效果。