The Multifaceted Mas-Related G Protein-Coupled Receptor Member X2 in Allergic Diseases and Beyond

Recent research on mast cell biology has turned its focus on MRGPRX2, a new member of the Mas-related G protein-coupled subfamily of receptors (Mrgprs), originally described in nociceptive neurons of the dorsal root ganglia. MRGPRX2, a member of this group, is present not only in neurons but also in mast cells (MCs), specifically, and potentially in other cells of the immune system, such as basophils and eosinophils. As emerging new functions for this receptor are studied, a variety of both natural and pharmacologic ligands are being uncovered, linked to the ability to induce receptor-mediated MC activation and degranulation. The diversity of these ligands, characterized in their human, mice, or rat homologues, seems to match that of the receptor’s interactions. Natural ligands include host defense peptides, basic molecules, and key neuropeptides such as substance P and vasointestinal peptide (known for their role in the transmission of pain and itch) as well as eosinophil granule-derived proteins. Exogenous ligands include MC secretagogues such as compound 48/80 and mastoparan, a component of bee wasp venom, and several peptidergic drugs, among which are members of the quinolone family, neuromuscular blocking agents, morphine, and vancomycin. These discoveries shed light on its capacity as a multifaceted participant in naturally occurring responses within immunity and neural stimulus perception, as in responses at the center of immune pathology. In host defense, the mice Mrgprb2 has been proven to aid mast cells in the detection of peptidic molecules from bacteria and in the release of peptides with antimicrobial activities and other immune mediators. There are several potential actions described for it in tissue homeostasis and repair. In the realm of pathologic response, there is evidence to suggest that this receptor is also involved in chronic inflammation. Furthermore, MRGPRX2 has been linked to the pathophysiology of non-IgE-mediated immediate hypersensitivity drug reactions. Different studies have shown its possible role in other allergic diseases as well, such as asthma, atopic dermatitis, contact dermatitis, and chronic spontaneous urticaria. In this review, we sought to cover its function in physiologic processes and responses, as well as in allergic and nonallergic immune disease.     

控制爆破法处理卡钻事故

介绍了在包头市某工程实施管道穿越黄河施工中,采用爆破法处理卡钻的经验。针对深水环境条件及钻杆内径小不宜采用集团装药的条件,确定采用"小直径爆破筒,钻杆内部装药"的爆破方案,阐述了爆破设计及施工注意事项。可供类似工程参考。     

Torsional statics of two-dimensionally functionally graded microtubes

A size-dependent governing equation is derived to investigate the torsional static behaviors of two-dimensionally functionally graded microtubes based on the modified couple stress theory. The shear modulus is assumed to vary along the tube’s length direction according to an exponential distribute function, and varies along the tube’s radius direction according to a power-law function. A generalized differential quadrature method is developed to determine the rotational angle and shear stresses. Some illustrative examples are given to investigate the effects of applied torques, the length scale parameter and various material compositions on the torsional angle and shear stresses.     

扭臂式静电微驱动器的pulli-n现象分析

从扭臂式微驱动器模型出发,分析了器件在静电驱动条件下pulli-n现象的产生条件,并给出公式化结果。讨论了器件的几何结构参数对于pulli-n现象的影响,并对具体结构的器件给出了pulli-n角度和pulli-n电压等方面的分析结果。对于特定的扭臂结构,pulli-n角度为悬臂梁最大扭转角度的44.04%,且与扭臂的结构参数无关。     

轻质滤料滤池的试验与研究

轻质滤料滤池是以比水密度略小的滤料为滤床的滤池，通过以净水厂的原水和污水处理厂的二级处理出水为过滤试验对象，所取得的结果表明：下向流轻质滤料滤池对浊度和悬浮固体（SS）的去除率分别可以达到80％和45％，而滤床的水头损失不超过15cm。因此轻质滤料滤池可以以预过滤的形式配置在过滤处理的净水和污水的处理工艺中。     

磁场天线的扭转振动及运动感应噪声研究

拖曳天线的运动感应电磁噪声对其收信深度及接收性能占据主导作用,其中横向振动与纵向振动是主要的,同时扭转振动也不可忽略.建立了磁场天线的扭转振动模型,得到了流体圆周切变力作用下磁场天线的扭转振动响应,分析了扭转振动感应电磁噪声的产生机理,给出了计算公式及仿真结果.研究结果为水下电磁噪声的深入研究提供了理论基础.     

On the determination of optimal transition profile of a stepped bar in tension or in torsion by BEM

The objective is to have uniformly distributed tangential stresses on the transition profile of a stepped bar subjected to tensile and torsional loading using an axisymmetric boundary element formulation. The transition curve is represented by the Langragian interpolation polynomial with progressive degrees to avoid shape distortion during the optimization procedure. The calculated result is compared with that obtained by fluid dynamics given in the literature. It is seen that the transition curve obtained in this paper is reasonable.     

采用纯化学物质校准仪器测定钛合金中碳量

采用纯化学物质对高频加热－红外检测碳硫仪校准，对钛合金中的碳量进行测定。     

有水气藏开发早期可采储量的评价方法

有水气藏是天然气藏中的一个基本气藏类型，其采收率受多种因素的影响，如地面集输压力、井筒混合气水流动的液柱压力和储层物性等，目前普遍采用经验取值、物质平衡和气藏数值模拟等方法进行研究，但由于受开发评价阶段试采资料偏少和气藏数值模拟无法模拟井筒流动等因素的影响，早期采收率计算往往偏差较大，针对这些问题，从气田开发一体化的特点出发，提出了一种全面考虑地层→井筒→地面流动条件下，有水气藏（含凝析有水气藏）发废弃压力的计算方法，发展了利用物质平衡早期预测有水气藏采收率的理论，方法可靠、适用性强，能够推广应用。     

对称配筋小偏心受压构件的截面设计

对小偏心受压构件在对称配筋情况下的截面配筋计算，提出用最佳一次逼近多项式简化基本公式，直接按二次方程求解ξ的近似方法，具有精度高，相对误差小，计算方便等优点，可供工程设计人员参考。