Xanthohumol for Human Malignancies: Chemistry,Pharmacokinetics and Molecular Targets

Xanthohumol (XH) is an important prenylated flavonoid that is found within the inflorescence of Humulus lupulus L. (Hop plant). XH is an important ingredient in beer and is considered a significant bioactive agent due to its diverse medicinal applications, which include anti-inflammatory, antimicrobial, antioxidant, immunomodulatory, antiviral, antifungal, antigenotoxic, antiangiogenic, and antimalarial effects as well as strong anticancer activity towards various types of cancer cells. XH acts as a wide ranging chemopreventive and anticancer agent, and its isomer, 8-prenylnaringenin, is a phytoestrogen with strong estrogenic activity. The present review focuses on the bioactivity of XH on various types of cancers and its pharmacokinetics. In this paper, we first highlight, in brief, the history and use of hops and then the chemistry and structure–activity relationship of XH. Lastly, we focus on its prominent effects and mechanisms of action on various cancers and its possible use in cancer prevention and treatment. Considering the limited number of available reviews on this subject, our goal is to provide a complete and detailed understanding of the anticancer effects of XH against different cancers.     

Smart firefighting construction in China: Status,problems, and reflections

“Smart firefighting” construction as a part of the “smart city” has been a concern of the public security and fire agencies at all levels. In this study, the status, problems, and reflections of “smart firefighting” construction in China are discussed. A recent survey indicates that China has launched its smart firefighting construction and initially created a new perspective on its regional smart firefighting work based on three main aspects: intelligent disaster perception by Internet of Things (IoT) construction, intelligent disaster prevention by big data construction, and intelligent disaster disposal by emergency rescue platform construction. However, the current smart firefighting construction in China still has some prominent problems such as the data interconnectivity and normalized management of various platforms, the extensibility of smart firefighting platforms, and the intelligent level of smart firefighting researches, which need to be solved urgently. Therefore, we argue that smart firefighting construction in China should establish data interconnectivity, industrial normalized management, 2D/3D geographic information interaction and extension, high-integration fire protection theory, and many other aspects in the near future and truly realize firefighting visualization and efficient data applications for 4D time space. This study could provide valuable reference for smart firefighting and smart city construction.     

环保法规对船舶涂料企业的冲击及应对措施的探讨

随着我国环境保护法规《大气污染防治法》的修订和《涂料征收消费税通知》的公布,探讨了其对船舶涂料企业的冲击及其应对措施。     

综采工作面粉尘防治问题分析与技术改进

针对新桥煤矿2301综采工作面机载喷雾系统喷雾效果差、喷雾耗水量大造成煤质含水量超标、喷嘴雾化程度不高、喷嘴容易发生堵塞等问题,提出了高压喷雾系统设计方案,选择了1.2mm的锥形引射喷嘴和1.5mm的扇形引射喷嘴。采用固定水泵供水方式,结合工作面实际情况,计算出喷雾总用水量247.5L/min,提高了喷雾射程,提升了除尘效果。     

含硫化氢气井钻井过程中的腐蚀因素与防护研究

在含硫气井的钻井过程中对于HRC大于22的钻具钢材除了腐蚀疲劳之外，在pH值小于9的环境中会发生硫化物应力腐蚀破裂，这种破坏比腐蚀疲劳更突然、更快，使钻杆大量损坏。含硫气井在钻井过程中，由于湿硫化氢的出现，常常会出现油管、套管、钻井设备、钻井仪器以及对支持保护管柱的水泥环柱等腐蚀和损坏问题，为此，阐述了湿硫化氢的腐蚀特点、机理，归纳总结了影响腐蚀的因素，综述了如何在这些方面防止其腐蚀，使损失减小，为指导油管、套管防腐工程实践提供了依据。建议在钻井过程中采用碱性钻井液，其pH值可到9或更高(至pH值12)，以减缓或防止钻井过程中电化学从硫化物应力腐蚀破裂；含硫气井用的钻杆应该间歇使用。钻杆停用堆置时间可使其放氢，使钻杆恢复韧性，防止硫化物应力腐蚀断裂。     

游梁式抽油机间歇供电装置的研制与应用

针对游梁抽油机电动机效率低和井场窃电问题,研制了具有节电和防井场窃电功能的游梁抽油机调压+间歇供电装置。该装置通过控制可控硅的导通角实现在电动机做功期调压供电,在电动机发电期不供电。分析了间歇供电对电动机、抽油机和电网的影响;根据现场实测数据分析了该装置的节电效果及现场应用情况。该装置节电效果显著,能防止井场窃电,可用于对游梁抽油机电动机的长期驱动。     

Engineering Geological Problems of Levee Along Middle and Lower Reaches of Yangtze River

1　ＩｎｔｒｏｄｕｃｔｉｏｎＢｅｃａｕｓｅｏｆｔｈｅｃｏｍｐｌｉｃａｔｅｄｓｕｂｓｏｉｌｐｒｏｆｉｌｅ ,ｔｈｅｌｅｖｅｅａｌｏｎｇｍｉｄｄｌｅａｎｄｌｏｗｅｒｒｅａｃｈｅｓｏｆＹａｎｇｔｚｅ ,ａｂｏｕｔ 36 0 0ｋｍｌｏｎｇ ,ｈａｓｍａｎｙｈｉｄｄｅｎｐｅｒｉｌｓ .Ａｍｏｎｇｔｈｅｄａｎｇｅｒｏｕｓｅｖｅｎｔｓｄｕｒｉｎｇ 1998’ｓｆｌｏｏｄｓｅａｓｏｎｉｎｔｈｅｗｈｏｌｅｖａｌｌｅｙ ,12 .7%ｏｃ ｃｕｒｒｅｄａｌｏｎｇｔｈｅｔｒｕｎｋｓｔｒｅａｍｄｙｋｅｓ,ｏｆｗｈｉｃｈ 6 98ｗｅｒｅｔｈｅｍｏｓｔｄ…     

西津电站对南宁及贵港防洪的作用

江河中的闸坝、电站等水利工程的调度运行对其上下游城市防洪有着重要的作用。郁江上的西津电站在洪水期如何调度可减轻上游南宁及下游贵港的洪水压力?通过分析"2001 7"洪水的调度,论述调度过程的作用和效果,为以后的防洪调度提供决策参考。