全文获取类型
收费全文 | 254篇 |
免费 | 18篇 |
国内免费 | 4篇 |
专业分类
综合类 | 12篇 |
化学工业 | 64篇 |
金属工艺 | 1篇 |
机械仪表 | 12篇 |
建筑科学 | 15篇 |
轻工业 | 133篇 |
水利工程 | 3篇 |
石油天然气 | 1篇 |
一般工业技术 | 26篇 |
冶金工业 | 2篇 |
原子能技术 | 1篇 |
自动化技术 | 6篇 |
出版年
2024年 | 1篇 |
2023年 | 7篇 |
2022年 | 11篇 |
2021年 | 22篇 |
2020年 | 8篇 |
2019年 | 9篇 |
2018年 | 6篇 |
2017年 | 5篇 |
2016年 | 7篇 |
2015年 | 13篇 |
2014年 | 15篇 |
2013年 | 39篇 |
2012年 | 16篇 |
2011年 | 13篇 |
2010年 | 12篇 |
2009年 | 10篇 |
2008年 | 12篇 |
2007年 | 8篇 |
2006年 | 10篇 |
2005年 | 6篇 |
2004年 | 5篇 |
2003年 | 9篇 |
2002年 | 2篇 |
2001年 | 8篇 |
2000年 | 1篇 |
1999年 | 2篇 |
1998年 | 2篇 |
1997年 | 1篇 |
1996年 | 2篇 |
1995年 | 2篇 |
1994年 | 3篇 |
1993年 | 1篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1986年 | 2篇 |
1985年 | 2篇 |
1983年 | 1篇 |
1981年 | 1篇 |
排序方式: 共有276条查询结果,搜索用时 78 毫秒
1.
Wan Abd Al Qadr Imad Wan-Mohtar Zul Ilham Adi Ainurzaman Jamaludin Neil Rowan 《International journal of molecular sciences》2021,22(4)
Natural mycelial exopolysaccharide (EPS) and endopolysaccharide (ENS) extracted from bioreactor-cultivated European Ganoderma applanatum mushrooms are of potential high commercial value for both food and adjacent biopharmaceutical industries. In order to evaluate their potential toxicity for aquaculture application, both EPS (0.01–10 mg/mL) and ENS (0.01–10 mg/mL) extracts were tested for Zebrafish Embryo Toxicity (ZFET); early development effects on Zebrafish Embryos (ZE) were also analyzed between 24 and 120 h post-fertilization (HPF). Both EPS and ENS are considered non-toxic with LC50 of 1.41 mg/mL and 0.87 mg/mL respectively. Both EPS and ENS did not delay hatching and teratogenic defect towards ZE with <1.0 mg/mL, respectively. No significant changes in the ZE heart rate were detected following treatment with the two compounds tested (EPS: 0.01–10 mg/mL: 176.44 ± 0.77 beats/min and ENS: 0.01–10 mg/mL: 148.44 ± 17.75 beats/min) compared to normal ZE (120–180 beats/min). These initial findings support future pre-clinical trials in adult fish models with view to safely using EPS and ENS as potential feed supplements for supplements for development of the aquaculture industry. 相似文献
2.
Jiri Patocka Ran Wu Eugenie Nepovimova Martin Valis Wenda Wu Kamil Kuca 《International journal of molecular sciences》2021,22(4)
Mushroom poisoning has always been a threat to human health. There are a large number of reports about ingestion of poisonous mushrooms every year around the world. It attracts the attention of researchers, especially in the aspects of toxin composition, toxic mechanism and toxin application in poisonous mushroom. Inocybe is a large genus of mushrooms and contains toxic substances including muscarine, psilocybin, psilocin, aeruginascin, lectins and baeocystin. In order to prevent and remedy mushroom poisoning, it is significant to clarify the toxic effects and mechanisms of these bioactive substances. In this review article, we summarize the chemistry, most known toxic effects and mechanisms of major toxic substances in Inocybe mushrooms, especially muscarine, psilocybin and psilocin. Their available toxicity data (different species, different administration routes) published formerly are also summarized. In addition, the treatment and medical application of these toxic substances in Inocybe mushrooms are also discussed. We hope that this review will help understanding of the chemistry and toxicology of Inocybe mushrooms as well as the potential clinical application of its bioactive substances to benefit human beings. 相似文献
3.
Jeremy R. Schwartzbord Jef L. Leroy Linda Severe Dan L. Brown 《Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment》2016,33(6):1036-1042
Aflatoxins (AFs) are hepatocarcinogenic mycotoxins that can contaminate grains and oil seeds in tropical and sub-tropical areas and have been detected in maize and peanut products of Haiti. The first objective was to assess human exposure to AFs among Haitians at an urban hospital (GHESKIO) and a rural health centre (HCBH). The second objective was to test the association between AF exposure and reported dietary intake of potentially contaminated foods, such as maize, peanut products and milk. Measurement of urinary AFM1 by HPLC revealed that among 367 participants 14% and 22% at GHESKIO and HCBH, respectively, had detectable AFM1. The maximum and median AFM1 concentrations for all detected samples were 700 pg AFM1 ml–1 and 11.7 pg ml–1, respectively. Detection of AFM1 was significantly associated with peanut consumption (p < 0.05). Controlling for diet and age group in a logit model, patients who reported peanut consumption the day of the survey and patients from HCBH had greater log odds of excreting detectable AFM1 (p < 0.001 and 0.002, respectively); females had lower log odds (p = 0.020). Recalled frequency of consuming non-dairy animal-sourced foods, an indicator of diet quality, approached significance (p = 0.056) as an inverse predictor of urinary AFM1 detection. The findings augur the need for interventions that will improve food safety in Haiti and limit exposure to AFs, particularly among rural communities. 相似文献
4.
Kseniya Khamina Andreas B. Diendorfer Susanna Skalicky Moritz Weigl Marianne Pultar Teresa L. Krammer Catharine Aquino Fournier Amy L. Schofield Carolin Otto Aaron Thomas Smith Nina Buchtele Christian Schoergenhofer Bernd Jilma Bernhard J. H. Frank Jochen G. Hofstaetter Regina Grillari Johannes Grillari Klemens Ruprecht Christopher E. Goldring Hubert Rehrauer Warren E. Glaab Matthias Hackl 《International journal of molecular sciences》2022,23(3)
5.
免疫婴儿乳粉的安全毒理学评定 总被引:1,自引:0,他引:1
以24株人肠道病原菌(包括病原性大肠杆菌12株、沙门氏菌8株、志贺氏菌3株、小肠结肠炎耶尔森氏菌1株)作为抗原,对乳牛进行系统免疫,免疫乳与非免疫乳乳中IgG含量无显著差异。系统免疫并不增加乳中IgG的含量,但IgG的抗体特异性大大增强,所得的免疫初乳中乳抗体对24种不同病原菌的凝集价为28~212,为普通初乳中乳抗体凝集价的32~256倍。以免疫初乳作为原料制备免疫初乳粉并添加到婴儿乳粉中制成免疫婴儿乳粉。婴儿免疫乳粉LD50>10g/kg;Ames试验及小鼠骨髓微核试验和小鼠精子畸变试验表明婴儿免疫乳粉无致畸变作用。大鼠30d喂养试验表明,婴儿免疫乳粉对大鼠生长无不良影响,大鼠血液指标正常,病理学检查未见任何病变。 相似文献
6.
7.
8.
9.
Deiweson Souza-Monteiro Mrcia Cristina dos Santos Guerra Leonardo Oliveira Bittencourt Walessa Alana Bragana Arago Aline Dionizio Felipe Martins Silveira Marília Afonso Rebelo Buzalaf Manoela Domingues Martins Maria Elena Crespo-Lopez Rafael Rodrigues Lima 《International journal of molecular sciences》2022,23(4)
Aluminum (Al) is one of the most abundant elements on Earth, and its high extraction rate and industrial use make human exposure very common. As Al may be a human toxicant, it is important to investigate the effects of Al exposure, mainly at low doses and for prolonged periods, by simulating human exposure. This work aimed to study the effects of low-dose exposure to chloride aluminum (AlCl3) on the oxidative biochemistry, proteomic profile, and morphology of the major salivary glands. Wistar male rats were exposed to 8.3 mg/kg/day of AlCl3 via intragastric gavage for 60 days. Then, the parotid and submandibular glands were subjected to biochemical assays, proteomic evaluation, and histological analysis. Al caused oxidative imbalance in both salivary glands. Dysregulation of protein expression, mainly of those related to cytoarchitecture, energy metabolism and glandular function, was detected in both salivary glands. Al also promoted histological alterations, such as acinar atrophy and an increase in parenchymal tissue. Prolonged exposure to Al, even at low doses, was able to modulate molecular alterations associated with morphological impairments in the salivary glands of rats. From this perspective, prolonged Al exposure may be a risk to exposed populations and their oral health. 相似文献