The Young Scientists Network: How the European Federation for Medicinal Chemistry (EFMC) Became Young Again

The European Federation for Medicinal Chemistry (EFMC) created the Young Scientists Network (YSN) to support early-career medicinal chemists and chemical biologists. By doing this, it addressed the rapid changes taking place in the scientific community and in our society, such as the rise of social media, the evolution of the gender balance in the scientific population, and educational needs. Creating the YSN was also a way to ensure that the next generation of scientists would contribute to shaping EFMC's strategy, while recognizing and addressing their needs. The YSN was set up as a very dynamic concept, and has now developed to the point where its impact is evident. The activities it promotes complement EFMC's community support and scientific opportunities, rejuvenating the Federation and preparing it for the future. It also provides opportunities for many brilliant young scientists, who do not hesitate to invest time and energy in supporting our community and shaping their own future.     

中小企业安全评价模式探讨

在分析我国中小企业安全生产状况的基础上,提出两步安全评价模式。该模式适合中小企业的特点,通过安全评价,使企业管理者一方面了解企业的综合安全状况,做到心中有数;另一方面明确企业的最高风险所在,从而找到改善企业安全状况的有效途径。     

50 Years European Federation for Medicinal Chemistry (EFMC) – The Ascent of Medicinal Chemistry in Europe

A historical overview of key events that led, 50 years ago, to the foundation of the European Federation for Medicinal Chemistry (EFMC), and the impact this had on promoting and structuring medicinal chemistry as a discipline in Europe. EFMC, together with the growing number of newly established national medicinal chemistry societies or divisions, created the framework for networking and knowledge exchange. This includes organizing conferences, in particular its biennial ‘International Symposium on Medicinal Chemistry (EFMC-ISMC)’. Several interesting trends can be identified from EFMC meetings, EFMC governing bodies, or the federation's recognition of scientific excellence, that highlight changes in the medicinal chemistry community over the last decades, related to affiliation, gender, young scientists, communication tools, and embracing scientific advances.     

The Chemical Biology-Medicinal Chemistry Continuum: EFMC′s Vision

The E uropean F ederation for M edicinal chemistry and C hemical biology (EFMC) is a federation of learned societies. It groups organizations of European scientists working in a dynamic field spanning chemical biology and medicinal chemistry. New ideas, tools, and technologies emerging from a wide array of scientific disciplines continuously energize this rapidly evolving area. Medicinal chemistry is the design, synthesis, and optimization of biologically active molecules aimed at discovering new drug candidates – a mission that in many ways overlaps with the scope of chemical biology. Chemical biology is by now a mature field of science for which a more precise definition of what it encompasses, in the frame of EFMC, is timely. This article discusses chemical biology as currently understood by EFMC, including all activities dealing with the design and synthesis of biologically active chemical tools and their use to probe, characterize, or influence biological systems.     

挖掘机电液流量匹配控制系统动态性能研究

分析了液压挖掘机基于与负载压力无关流量分配（LUDV）多路阀的电液流量匹配控制（EFMC）系统的控制原理,建立了EFMC系统的液压挖掘机虚拟样机模型,采用实时检测油缸速度信号的反馈闭环控制方法提高流量匹配的精度。分别建立液压挖掘机EFMC系统动力学模型与液压系统模型并根据其实际工况进行联合仿真,研究了挖掘作业过程动态特性及节能特性。与传统的基于LUDV的负载敏感系统实验结果进行对比,结果表明: EFMC系统与传统负载敏感系统相比,改善了系统的动态响应特性和稳定性,泵的压力裕度明显减小,提高了系统的节能性,反馈闭环控制系统动态响应特性也明显得到提高。研究方法可为进一步研究挖掘机的动态性、节能性、稳定性提供理论依据和参考。     

The Facets of Diversity: The EFMC Perspective**

Diversity in science refers to cultivating talent, while promoting full inclusion across the community. In medicinal chemistry and chemical biology, it enhances creativity and encourages contributions from multiple perspectives, leading to better decision making and broader scientific impact. The European Federation for Medicinal chemistry and Chemical biology (EFMC) embraces and promotes diversity, to ensure representation of all talents, and enable equality of opportunity through fairness and transparency. EFMC has historically paid continuous attention to diversity in terms of culture, geography and equilibrium between academia and industry, with over the last few years a focus on increasing gender balance, aiming at a fair representation of the scientific community and equal opportunities independently of gender. EFMC promotes cultural diversity as it reinforces openness and mutual respect. All scientific organizations of a scope compatible with its remit are welcome within EFMC, where their members benefit from a welcoming, psychologically safe, and stimulating environment. Herein, we describe the state of diversity within the EFMC, how the situation has evolved over the years and where diversity should be further encouraged.