一种新的线性分布参数系统辨识方法

本文应用块脉冲函数（ＢＰＦ）将含有未知参数的线性分布参数系统偏微分方程转换为矩阵方程，通过最小二乘法辨识线性分布参数系统的参数，辨识结果表明，ＢＰＦ辨识法具有原理简捷，实现方便，辨识精度高等优点。     

采取具体措施 发挥教研室的职能作用

本文就如何发挥高校教研室的职能作用记述了本教研室所采取的具体方法和措施。     

一类全不连通分形图的构造

为构造一类全不连通的分形图 ,利用了适当的类康托集 ,将某一迭代函数系统升腾为高维空间上的升腾迭代函数系统 ,并通过参数调整构造出大量造型上全不连通的分形图 ,同时发现了类康托集的结构和分形图的结构之间的变化关系 ,实验结果表明 ,该方法简单易用 .     

用临界点附近的涨落讨论Landau相变理论适用范围

Landau相变理论是研究晶体各种结构相变的有力工具.在临界点附近某些序参量的涨落很大,导致Landau相变理论失去作用.在自由能密度的展开式中需要考虑Ginzburg梯度项,通过对相对几率和关联函数的傅里叶分量来分析临界点附近的序参量的涨落,并由此得出Landau相变理论的适用范围.     

服装结构的功能性

分析了服装结构中各部分的功能.讨论了功能性服装的设计原则.阐述了CAD在服装设计中的应用.     

热连轧控制系统优化设计和最优控制

提出了用于热连轧分层递阶智能控制中的张力复合最优控制系统,板形板厚协调最优控制和速度设定的温度控制等３个子控制系统的优化设计方案,应用轧制主程和二次型目标函数推出板形板厚协调闭环最优控制、穿带过程辊缝最佳校正、轧辊凸度实时估计,最佳轧辊凸度设定和最佳弯辊力设定等热连轧过程优化策略。     

IP多媒体子系统在线计费费率功能模块的设计与实现

在3G IMS系统中,在线实时计费是非常重要的一种计费单元,而费率功能模块是该计费系统的核心.由于3G IMS计费系统处理的是多种复杂应用与服务混合的计费内容,所以对费率功能模块的设计与实现提出了较高的要求,并成为当前的研究热点之一.在分析IMS在线计费系统的基础之上,对复杂应用和服务进行了研究,提出了费率功能模块的针...     

幂指数模型模拟玉米弯孢菌叶斑病传播梯度的试验

采用人工接种方法，在田间造成玉米弯孢菌叶斑病不同的发病梯度。利用SAS统计软件构建了该病害传播梯度的幂指数模型，结果表明幂指数模型可以模拟该病害传播动态，同时推导该病害在一个月最远传播距离为16m，两个月最远传播距离为28m。     

THE TRUE DIMENSION OF CERTAIN ALTERNANT CODES

By applying a result from geometric Goppa codes, due to H.Schtenoth, the true dimension of certain alternant codes is calculated. The results lead in many cases to an improvement of the usual lower bound for the dimension.     

Establishment and Characterization of Novel Human Intestinal In Vitro Models for Absorption and First-Pass Metabolism Studies

Commonly used intestinal in vitro models are limited in their potential to predict oral drug absorption. They either lack the capability to form a tight cellular monolayer mimicking the intestinal epithelial barrier or the expression of cytochrome P450 3A4 (CYP3A4). The aim of this study was to establish a platform of colorectal cancer patient-derived cell lines for evaluation of human intestinal drug absorption and metabolism. We characterized ten 2D cell lines out of our collection with confluent outgrowth and long-lasting barrier forming potential as well as suitability for high throughput applications with special emphasis on expression and inducibility of CYP3A4. By assessment of the transepithelial electrical resistance (TEER) the cells barrier function capacity can be quantified. Very high TEER levels were detected for HROC60. A high basal CYP3A4 expression and function was found for HROC32. Eight cell lines showed higher CYP3A4 induction by stimulation via the vitamin D receptor compared to Caco-2 cells (5.1- to 16.8-fold change). Stimulation of the pregnane X receptor led to higher CYP3A4 induction in two cell lines. In sum, we identified the two cell lines HROC183 T0 M2 and HROC217 T1 M2 as useful tools for in vitro drug absorption studies. Due to their high TEER values and inducibility by drug receptor ligands, they may be superior to Caco-2 cells to analyze oral drug absorption and intestinal drug–drug interactions. Significance statement: Selecting appropriate candidates is important in preclinical drug development. Therefore, cell models to predict absorption from the human intestine are of the utmost importance. This study revealed that the human cell lines HROC183 T0 M2 and HROC217 T1 M2 may be better suited models and possess higher predictive power of pregnane X receptor- and vitamin D-mediated drug metabolism than Caco-2 cells. Consequently, they represent useful tools for predicting intestinal absorption and simultaneously enable assessment of membrane permeability and first-pass metabolism.