红外热成像在乳腺疾病检测的应用研究

乳腺疾病已严重危害女性身心健康,其中乳腺癌更位居全球范围内女性癌症发病率和死亡率首位,因此乳腺癌的早期发现意义重大。传统结构影像学早期检测疾病具有一定局限性,而红外热成像作为功能成像技术可为乳腺癌的早期筛查提供有效线索。因此本文主要就红外热成像在乳腺疾病的早期检测及预后评估的应用价值进行综述。     

黄沙坪铅锌多金属矿的成矿规律及深部找矿远景

众所周知,矿物质的成分是多种多样的,社会的发展和科学的进步需要运用到多重金属矿物质,在专业人员的勘探与挖掘中,发现了黄沙坪铅锌多金属矿,这个矿区中有丰富的有色金属,这个矿的发掘为研究成矿规律提供了物质基础,同时也为深部找矿提供了可靠的依据。本文主要分析黄沙坪铅锌多金属矿的成矿规律及深部找矿远景。     

CHID1 Is a Novel Prognostic Marker of Non-Small Cell Lung Cancer

There is an urgent need for identification of new prognostic markers and therapeutic targets for non-small cell lung cancer (NSCLC). In this study, we evaluated immune cells markers in 100 NSCLC specimens. Immunohistochemical analysis revealed no prognostic value for the markers studied, except CD163 and CD206. At the same time, macrophage markers iNOS and CHID1 were found to be expressed in tumor cells and associated with prognosis. We showed that high iNOS expression is a marker of favorable prognosis for squamous cell lung carcinoma (SCC), and NSCLC in general. Similarly, high CHID1 expression is a marker of good prognosis in adenocarcinoma and in NSCLC in general. Analysis of prognostic significance of a high CHID1/iNOS expression combination showed favorable prognosis with 20 months overall survival of patients from the low CHID1/iNOS expression group. For the first time, we demonstrated that CHID1 can be expressed by NSCLC cells and its high expression is a marker of good prognosis for adenocarcinoma and NSCLC in general. At the same time, high expression of iNOS in tumor cells is a marker of good prognosis in SCC. When used in combination, CHID1 and iNOS show a very good prognostic capacity for NSCLC. We suggest that in the case of lung cancer, tumor-associated macrophages are likely ineffective as a therapeutic target. At the same time, macrophage markers expressed by tumor cells may be considered as targets for anti-tumor therapy or, as in the case of CHID1, as potential anti-tumor agents.     

Stromal CCL5 Promotes Breast Cancer Progression by Interacting with CCR3 in Tumor Cells

Chemokines secreted from stromal cells have important roles for interactions with carcinoma cells and regulating tumor progression. C-C motif chemokine ligand (CCL) 5 is expressed in various types of stromal cells and associated with tumor progression, interacting with C-C chemokine receptor (CCR) 1, 3 and 5 expressed in tumor cells. However, the expression on CCL5 and its receptors have so far not been well-examined in human breast carcinoma tissues. We therefore immunolocalized CCL5, as well as CCR1, 3 and 5, in 111 human breast carcinoma tissues and correlated them with clinicopathological characteristics. Stromal CCL5 immunoreactivity was significantly correlated with the aggressive phenotype of breast carcinomas. Importantly, this tendency was observed especially in the CCR3-positive group. Furthermore, the risk of recurrence was significantly higher in the patients with breast carcinomas positive for CCL5 and CCR3 but negative for CCR1 and CCR5, as compared with other patients. In summary, the CCL5-CCR3 axis might contribute to a worse prognosis in breast cancer patients, and these findings will contribute to a better understanding of the significance of the CCL5/CCRs axis in breast carcinoma microenvironment.     

Polymorphisms in EGFR Gene Predict Clinical Outcome in Unresectable Non-Small Cell Lung Cancer Treated with Radiotherapy and Platinum-Based Chemoradiotherapy

For non-small cell lung cancer (NSCLC), radiotherapy (RT) and platinum-based chemotherapy (CHT) are among the main treatment options. On the other hand, radioresistance and cytotoxic drug resistance are common causes of failure. The epidermal growth factor receptor (EGFR) plays an important role in radioresponse and therapy resistance. We hypothesized that single nucleotide polymorphisms (SNPs) in the EGFR gene might affect individual sensitivity to these treatments, and thus, therapy outcome and prognosis. The association between functional EGFR SNPs and overall (OS), locoregional recurrence-free (LFRS), and metastasis-free (MFS) survival was examined in 436 patients with unresectable NSCLC receiving RT and platinum-based CHTRT. In a multivariate analysis, the rs712830 CC homozygotes showed reduced OS in the whole group (p = 0.039) and in the curative treatment subset (p = 0.047). The rs712829 TT genotype was strongly associated with decreased LRFS (p = 0.006), and the T-C haplotype was a risk factor for locoregional recurrence in our patients (p = 0.003). The rs2227983 GG alone and in combination with rs712829 T was an indicator of unfavorable LRFS (p = 0.028 and 0.002, respectively). Moreover, significant independent effects of these SNPs on OS, LRFS, and MFS were observed. Our results demonstrate that inherited EGFR gene variants may predict clinical outcomes in NSCLC treated with DNA damage-inducing therapy.     

Molecular Genetics of Conjunctival Melanoma and Prognostic Value of TERT Promoter Mutation Analysis

The aim of this study was exploration of the genetic background of conjunctival melanoma (CM) and correlation with recurrent and metastatic disease. Twenty-eight CM from the Rotterdam Ocular Melanoma Study group were collected and DNA was isolated from the formalin-fixed paraffin embedded tissue. Targeted next-generation sequencing was performed using a panel covering GNAQ, GNA11, EIF1AX, BAP1, BRAF, NRAS, c-KIT, PTEN, SF3B1, and TERT genes. Recurrences and metastasis were present in eight (29%) and nine (32%) CM cases, respectively. TERT promoter mutations were most common (54%), but BRAF (46%), NRAS (21%), BAP1 (18%), PTEN (14%), c-KIT (7%), and SF3B1 (4%) mutations were also observed. No mutations in GNAQ, GNA11, and EIF1AX were found. None of the mutations was significantly associated with recurrent disease. Presence of a TERT promoter mutation was associated with metastatic disease (p-value = 0.008). Based on our molecular findings, CM comprises a separate entity within melanoma, although there are overlapping molecular features with uveal melanoma, such as the presence of BAP1 and SF3B1 mutations. This warrants careful interpretation of molecular data, in the light of clinical findings. About three quarter of CM contain drug-targetable mutations, and TERT promoter mutations are correlated to metastatic disease in CM.     

葫芦岛市钢屯镇赵家屯西山铜钼多金属矿成矿远景及找矿标志

赵家屯西山铜钼多金属矿位于葫芦岛市北西的钢屯镇南部,行政隶属于葫芦岛市连山区钢屯镇境内,位于杨家杖子—八家子构造岩浆的活动带内。区内燕山期花岗岩浆多次侵入,对成矿物质的活化集中起到重要的作用,是主要的物质来源及热动力条件;受区域性构造活动的影响,断裂构造发育,为成矿提供了重要的赋矿空间。地层、构造、岩浆岩三位一体的空间有利于多金属矿床的产出,具备形成热液充填交代型矿床的条件。     

广东阳春石菉—鹦鹉岭—锡山铜锡多金属矿集区综合地球物理特征与成矿预测

石菉—鹦鹉岭—锡山一带是粤西地区的一个铜锡钨（铅锌）多金属矿密集区,矿床（点）众多,区内矿床勘查工作多开展于20世纪90年代前,勘查深度浅,且各矿床之间均为大面积第四系覆盖区,研究程度低,各矿床深部和外围均有良好的找矿前景。本文通过对该区开展的1∶5万重力测量、1∶1万地面磁法测量以及典型矿床电磁法剖面测量等工作成果的综合研究,认为本区主要为北西和北东向的区域构造控岩、控矿,综合物探成果反映空白区内隐伏构造发育,成矿地质条件有利,具备寻找新的中大型隐伏矿床的条件。通过进一步工作,该区有望成为粤西地区重要的铜锡多金属矿田。     

基于SVM和Kalman预测的非线性系统故障预报

针对Kalman预测在非线性系统故障预报中预测误差较大的问题.提出一种基于支持向量机预测新息的Kalman预测方法.根据未知非线性系统的典型变量分析子空间模型进行Kalman预测.采用支持向量机时间序列预测算法预测未来时刻的新息,利用新息进行Kalman单步和多步预报.在连续搅拌反应器上的仿真研究表明:所提出方法能准确地预测较长时间段内故障过程的劣化趋势,预知可能发生的故障,使操作人员有时间采取必要措施消除故障隐患.     

Remote Sensing Prospecting in High Vegetation Coverage Area——A Case Study of the in Datuanbao Copper Ore Deposit

This article described the way to extract information of copper and lead anomaly in high vegetation coverage area through a case study from the Datuanbao copper ore deposit and its environs,Jiangcheng,Yunnan Province.Principal component analysis,false color composite,stretch Histogram and supervise classification etc were analyzed in the remote sensing images using ENVI4.6 software.It is suggested that the linear structure,which is delineated by convolution filter and morphological analysis method,is characterized by statistical self-similarity and fractal geometry.It is found that the high value of fractal dimension is roughly coincident with the copper and lead anomaly of vegetation by the comparison between contour maps of plant geochemical anomaly and fractal dimensions,which is calculated by box-counting.As a matter of fact,80 percent of copper and lead deposits or occurrences are located in areas of high value of fractal dimension and vegetation anomaly.By the comprehensive analysis of stratigraphy,igneous rocks,copper and lead mineralizations,fractal dimension of linear structures and vegetation anomaly from remote sensing,nine exploration targets with three levels of probabilities are figured out.